Patterns of Response to Immune Checkpoint Inhibitors in Sarcomas With High Tumor Burden and/or Mismatch Repair Deficiency

Alcindor, Thierry; Papke, David J.; Venkataraman, Vinayak; Wagner, Michael J.; Merriam, Priscilla; Haddox, Candace L.; Wagner, Andrew J.; Solimini, Nicole L.; Jambhekar, Ashwini; George, Suzanne

doi:10.1200/po-26-00414

Patterns of Response to Immune Checkpoint Inhibitors in Sarcomas With High Tumor Burden and/or Mismatch Repair Deficiency

PURPOSE Immune checkpoint inhibitors (ICIs) are frequently used to treat metastatic solid tumors characterized by high tumor mutational burden (TMB) and/or mismatch repair (MMR) deficiency. Most of the literature on their benefit is about carcinomas and melanomas, but little is known about their …