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Cannabinoids as Therapeutic Agents
Abstract
s of Papers, 188th Meet. American Chemical Soc., Philadelphia, August 1984, American Chemical Society, Washington, D.C., 1984; Abstr. MEDI,45. 35. Melvin, L. S., Johnson, M. R., and Milne, G. M., CP-55,244: a cannabinoid derived analgetic, in Abstracts of Papers, 186th Meet. American Chemical Soc., Washington, D.C., August 1983, American Chemical Society, Washington, D.C., 1983; Abstr. MEDI, 22. 36. Johnson, M. R., Eggler, J. F., Melvin, L. S., and Milne, G. M., Cannabinoid-derived therapeutants: further studies in the search for non-addicting drugs to relieve pain and discomfort, in Abstracts of Papers, 186th Meet, of the American Chemical Soc., Washington, D.C., Aug. 1983, American Chemical Society, Washington, D.C., 1983; Abstr. MEDI, 1. 37. Yaksh, T. L., The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat, /. Clin. Pharmacol.,21, 334s, 1981. 38. Dykstra, L. 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C., Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate, Nature (London), 248, 24, 1974. 44. Johnson, M. R., Schaaf, T. K., Constantine, J. W., and Hess, H.-J., Structure activity studies leading to a tissue-selective hypotensive prostaglandin analog, 13,14-dihydro-16-phenyl-w-tetranor PGE2, Prostaglandins, 20, 515, 1980. 45. Bordner, J., University of North Carolina, personal communication, 1979. 46. Edmonds, J. W. and Duax, W. L., Molecular conformation of prostaglandin Ez, Prostaglandins, 5, 275, 1974. 47. McCarthy, L. E. and Borison, H. L., Antiemetic activity of N-methyllevonantradol and nabilone in cisplatin-treated cats, J. Clin. Pharmacol.,21, 30s, 1981. 48. Cronin, C. M., Sallan, S. E., Gelber, R., Lucas, V. S., and Laszlo, J., Antiemetic effect of intramuscular levonantradol in patients receiving anticancer chemotherapy, J. Clin. Pharmacol.,21, 43s, 1981. 49. Embrey, M. P., Killer, K., and Mahendran, P., Termination of pregnancy by extraamniotic prostaglandins and the synergistic action of oxytocin, Adv. Biosci., 9, 507, 1973. 50. Craft, L, Oral prostaglandin E2 and amniotomy for induction of labor, Adv. Biosci., 9, 593, 1973. 51. Rich, W. M., Abdulhayoglu, G., and DiSaia, P. J., Methylprednisolone as an antiemetic during cancer chemotherapy — a pilot study, Gynecol. Oncol., 9, 193, 1980. 52. Home, W. C., Desacetyl-1-nantradol: a selective prostaglandin antagonist, Prostaglandins Leukotrienes and Med., 15, 129, 1984. 53. Hillard, C. J. and Bloom, A. S., Possible role of prostaglandins in the effects of the cannabinoids on adenylate cyclase activity, Eur. J. Pharmacol.,91, 21, 1983. 54. Loscher, W., 3-Mercaptopropionic acid: convulsant properties, effects on enzymes of the y-aminobutyrate system in mouse brain and antagonism by certain anticonvulsant drugs, aminooxyacetic acid and gabaculine, Biochem. Pharmacol.,28, 1397, 1979. 55. Revuelta, A. V., Cheney, D. L., Wood, P. L., and Costa, E., GABAergic mediation in the inhibition of hippocampal acetylcholine turnover rate elicited by A'-tetrahydrocannabinol, Neuropharmacology, 18, 525, 1979. 56. Leader, J. P., Koe, B. K., and Weissman, A., GABA-like actions of levonantradol, J. Clin. Pharmacol.,2\, 262s, 1981. 57. Koe, B. K. and Weissman, A., Facilitation of benzodiazepine binding by levonantradol, J. Clin. Pharmacol.,21, 397s, 1981. 58. Costa, E., Cheney, D. L., and Murray, T. F., Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum, J. Clin. Pharmacol.,21, 256s, 1981. 59. Koe, B. K., Milne, G. M., Weissman, A., Johnson, M. R., and Melvin, L. S., Enhancement of brain LHJFIunitrazepam binding and analgesic activity of synthetic cannabimimetics, Eur. J. Pharmacol., 109, 201, 1985. 60. Citron, M. L., Herman, T. S., Fossieck, B. E., Jr., Krasnow, S. 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B., Soukop, M., Cunningham, D., McArdle, C., Welsh, J., Stuart, F., Sangster, G., Kaye, S., Charlton, D., and Cash, H., A randomized multicenter single blind comparison of a cannabinoid anti-emetic (levonantradol) with chlorpromazine in patients receiving their first cytotoxic chemotherapy, Eur. J. Cancer Clin. Oncol., 19, 1087, 1983. 65. Gerhartz, H. H., Binsack, T., and Hiller, E., Levonantradol for the treatment of chemotherapyinduced nausea and vomiting, Klin. Wochenscfir.,61, 719, 1983. 66. Welsh, J., Stuart, F., Sangster, G., Milstead, R., Kaye, S., Cash, H., Charlton, D., and Caiman, K., Oral levonantradol in the control of cancer chemotherapy-induced emesis, Cancer Chemother. Pharmacol., 11, 66, 1983. 67. Sheidler, V. R., Ettinger, D. S., Diasio, R. B., Enterline, J. P., and Brown, M. D., Double-blind multiple-dose crossover study of the antiemetic effect of intramuscular levonantradol compared to prochlorperazine, /. Clin. Pharmacol.,24, 155, 1984. 68. Heim, M. E. and Queisser, W., Treatment of refractory cytostatic agent-induced vomiting with the synthetic cannabinoid levonantradol, Onkologie,S, 94, 1982. 69. Heim, M. E., Romer, W., and Queisser, W., Clinical experience with levonantradol hydrochloride in the prevention of cancer chemotherapy-induced nausea and vomiting, J. Clin. Pharmacol., 21, 86s, 1981. 70. Diasio, R. B., Ettinger, D. S., and Satterwhite, B. E., Oral levonantradol in the treatment of chemotherapy-induced emesis: preliminary observations, J. Clin. Pharmacol.,21, 81s, 1981. 71. Laszlo, J., Lucas, V. S., Jr., Hanson, D. C., Cronin, C. M., and S. E. Sallan, Levonantradol for chemotherapy-induced emesis: phase I-II oral administration, J. Clin. Pharmacol., 21, 51s, 1981. 1. Shapiro, B. J., Tashkin, D. P., and Vachon, L., THC as a bronchodilator. Why bother?, Chest, 71, 558, 1977. 2. Perez-Reyes, N., Lipton, M. A., Timmous, M. C., Wall, M. E., Brine, D. R., and Davis, K. H., Pharmacology of orally administered A'-THC, /. Clin. Pharm. Ther., 14, 48, 1973. 3. Abboud, R. T. and Sanders, H. D., Effect of oral administration of A'-THC on airways mechanics in normal and asthmatic subjects, Chest, 70, 480, 1976. 4. Davies, B. H., Radcliffe, S., Seaton, A., and Graham, J. D. P., A trial of oral A'-THC in reversible airways obstruction, Thorax, 30, 80, 1975. 5. Perez Reyes, M., Timmons, M. C., Davis, K. H., and Wall, M. C., A comparison of the pharmacological activity in man of intravenously administered A'-tetrahydrocannabinol, cannabinol, and cannabidiol, Experientia,29, 1368, 1973. 6. Malit, L. A., Johnstone, R. E., Bourke, D. L, Kulp, R. A., Klein, V., and Smith, T. C., Intravenous A'-THC: effects on ventilatory control and cardiovascular dynamics, Anaesthesiology, 42, 666, 1975. 7. Smith, T. C. and Kulp, R. A., Respiratory and cardiovascular effects of A'-THC alone and in combination with oxymorphone, pentobarbital and diazepam, in Therapeutic Potential of Marijuana, Cohen, S. and Stillman, R. 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E., and Harper, C. E., Subacute effects of heavy marijuana smoking on pulmonary function in healthy men, New Engl. J. Med., 294, 125, 1976. 15. Avakian, E. V., Horvath, S. M., Michael, E. D., and Jacobs, S., Effect of marijuana on cardiorespiratory responses to submaximal exercise, din. Pharmacol. Ther.,26, 77, 1979. 16. Tashkin, D. P., Calvarese, B. M., Simmons, S., and Shapiro, B. J., Respiratory status of seventy four habitual marijuana smokers, Chest, 78, 699, 1980. 17. Tashkin, D. P., Calv
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