Intracellular Calcium-Dependent Proteolysis

Abstract

Structural and Regulatory Properties of the Calpains and Calpastatins: Historical Background and Current Status of the Ca 2+ Dependent Proteinase System (D.E. Goll, W.C. Kleese, A. Okitani, T. Kumamoto, J. Cong, and H.-P. Kapprell). The Structures of Calpains and the Calpain Gene (K. Suzuki). Structure-Function Relationships of Calpastatins (M. Maki, M. Hatanaka, E. Takano, and T. Murachi). Calpain Substrate Specificity (K. Takahashi). Protein and Peptide Inhibitors of Calpains (C. Crawford). Subunit Autolysis and Regulation of Calpain II Activity (D.R. Hathaway and P. McClelland). Regulation of Calcium-Dependent Protease Activity In Vitro (D.E. Croall and G.N. DeMartino). The Regulation of Calpains by Interaction with Calpastatins (R.L. Mellgren and R.D. Lane). Calcium-Dependent Proteinases and Their Inhibitor in Drosophila (P. Friedrich and M. PintTr). Calcium-Dependent Proteinases in Crustaceans (D.L. Mykles and D.M. Skinner). Function of the Calcium-Dependent Proteolytic Sys tem in Normal Physiology and Pathophysiology: Introduction: Physiological Significance of the Calcium-Calpastatin System (T. Murachi). The Calpain-Calpastatin System and Membrane Fusion (N.S. Kosower and T. Glaser). Calpains and Regulation of Protein Kinase C (K. Hashimoto, K. Mikawa, T. Kuroda, K. Ase, and A. Kishimoto). Calpains and the Cytoskeleton (R.L. Shoeman and P. Traub). Calpains and Hemostasis (R.W. Colman and I. Hoffman). Erythrocyte Calpain in Health and Disease (S. Pontremoli and E. Melloni). The Degradation of Neurofilaments by Calpains (W.W. Schlaepfer and U.-J.P. Zimmerman). Plasticity to Pathology: Brain Calpains as Modifiers of Synaptic Structure (P. Seubert and G. Lynch). Calpains in Lens and Cataract (T.R. Shearer and L.L. David). Index.