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Molecular pharmacology
Abstract
Today&s;s pharmaceutical industry was founded on the productive interactions between the disciplines of synthetic organic chemistry and pharmacology, which occurred at the beginning of the twentieth century. This alliance has led to the production of many small organic molecules with effective therapeutic properties (Weatherall, 1990; Maxwell and Eckhardt, 1990; Silverman, 1992). In contrast, the first phase of pharmaceutical biotechnology was focused primarily on large proteins as drugs. This early phase of biotechnology is undergoing a rapid change as the second phase is spurred forward by the exciting developments in molecular biology and cell biology during the last decade (Gibbons, 1992). These developments are forging a fusion of biotechnology with the traditional methods of drug discovery.
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Cited by
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
Zhou, S.-F. (2008) · Xenobiotica · doi:10.1080/00498250701867889 · Cited by 599
The Runner's High: Opioidergic Mechanisms in the Human Brain
Boecker, H., Sprenger, T., Spilker, M. E., Henriksen, G., Koppenhoefer, M., Wagner, K. J., Valet, M., Berthele, A., & Tolle, T. R. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn013 · Cited by 527
Rodríguez-Antona, C., Donato, M. T., Boobis, A., Edwards, R. J., Watts, P. S., Castell, J. V., & Gómez-Lechón, M.-J. (2002) · Xenobiotica · doi:10.1080/00498250210128675 · Cited by 420
Myers, C. R., Carstens, B. P., Antholine, W. E., & Myers, J. M. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.00910.x · Cited by 250
Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability
Howgate, E. M., Rowland Yeo, K., Proctor, N. J., Tucker, G. T., & Rostami-Hodjegan, A. (2006) · Xenobiotica · doi:10.1080/00498250600683197 · Cited by 223
Metadata
- Venue
- Pharmaceutical Design And Development
- Publisher
- CRC Press
- Published
- 1994-03-31
- Pages
- 138-183
- OpenAlex
- W4236670183
- Cited by
- 784
- References
- 0
- FWCI
- 171.16
- Type
- book chapter
- Language
- en
- Open access
- closed
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