The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Elevated Free Radical Products in the Cerebrospinal Fluid of VLBW Infants with Cerebral White Matter Injury
Abstract
Free radical mediated cellular injury has been hypothesized to play a key role in the pathogenesis of white matter injury in the premature infant, although direct evidence is lacking. Between April 1999 and May 2001, 22 very low birthweight infants, 30 term infants, and 17 adults had samples of cerebrospinal fluid (CSF) collected for clinical indications. Only CSF samples without any evidence of meningeal inflammation were analyzed for the levels of the lipid peroxidation products, 8-isoprostane and malondialdehyde (MDA), and protein carbonyls as a measure of protein oxidation. Chlorotyrosine was monitored as a measure of neutrophil oxidative activity. In the premature infants with subsequent evidence of white matter injury on magnetic resonance imaging at term, there was a significant elevation in the CSF level of protein carbonyls in comparison with the level in healthy premature infants, term infants, and adult controls (all p < 0.001). A significant difference in the levels of the lipid peroxidation products, 8-isoprostane and MDA, was apparent between premature infants with white matter injury and adult controls (isoprostanes p = 0.02, MDA p = 0.014). There was a trend toward higher levels of 8-isoprostane in the premature infants with white matter injury in comparison with those without white matter injury (p = 0.08), with 5 of the 14 infants with white matter injury having levels that were more than 10-fold higher than the top of the adult range. There was no significant difference in the level of chlorotyrosines among any of the groups. These preliminary data provide evidence of an association of elevated oxidative products during the evolution of white matter injury in the human premature infant.
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“Analysis of patient samples demonstrated the presence of abundant lipid oxidation products, such as 8-isoprostane and malondialdehyde (MDA) in the cerebrospinal fluid of infants with white matter injuries [66].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [66]
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Cites
[43] Malondialdehyde determination as index of lipid Peroxidation
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[37] Carbonyl assays for determination of oxidatively modified proteins
Levine, R. L., Williams, J. A., Stadtman, E. R., & Shacter, E. B. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33040-9 · Cited by 2,707
Lipid peroxidation: its mechanism, measurement, and significance
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Neurologic and Developmental Disability after Extremely Preterm Birth
Wood, N. S., Marlow, N., Costeloe, K., Gibson, A. T., & Wilkinson, A. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008103430601 · Cited by 1,351
Measurement of F2-isoprostanes as an index of oxidative stress in vivo
Roberts, L. J., & Morrow, J. D. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00264-6 · Cited by 1,000
Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 936
Self-citationProtein Carbonyl Measurement by a Sensitive ELISA Method
Buss, H., Chan, T., Sluis, K. B., Domigan, N. M., & Winterbourn, C. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00104-4 · Cited by 687
Self-citationBack, S. A., Gan, X., Li, Y., Rosenberg, P. A., & Volpe, J. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06241.1998 · Cited by 586
Self-citationThe isoprostanes: Unique bioactive products of lipid peroxidation
Morrow, J. D., & Roberts, L. J. (1997) · Progress in Lipid Research · doi:10.1016/s0163-7827(97)00001-5 · Cited by 556
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Ferroptosis: Death by Lipid Peroxidation
Yang, W. S., & Stockwell, B. R. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.014 · Cited by 3,088
Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances
Volpe, J. J. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70294-1 · Cited by 2,501
Self-citationFerrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146
Pathogenesis of cerebral white matter injury of prematurity
Khwaja, O., & Volpe, J. J. (2008) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2006.108837 · Cited by 673
Self-citationCerebral White Matter Injury of the Premature Infant—More Common Than You Think
Volpe, J. J. (2003) · PEDIATRICS · doi:10.1542/peds.112.1.176 · Cited by 538
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Metadata
- Authors
- Inder, T., Mocatta, T., Darlow, B., Spencer, C., Volpe, J. J., & Winterbourn, C.
- Affiliations
- Royal Children's Hospital (AU)
- Corresponding author
- Inder, Terrie
- Venue
- Pediatric Research
- Published
- 2002-08
- Volume
- 52
- Issue
- 2
- Pages
- 213-218
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2069334549
- Cited by
- 125
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Neurological Foundation of New Zealand
- Health Research Council of New Zealand
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- very low birth weight infants, cerebral white matter injury, oxidative stress, free radicals, cerebrospinal fluid biomarkers, lipid peroxidation, 8-isoprostane, malondialdehyde, protein carbonyls, chlorotyrosine, neutrophil oxidative activity
- MeSH terms
- Brain, Free Radicals, Humans, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging, Nerve Fibers, Lipid Peroxidation, Biomarkers, Linear Models, Oxidative Stress, Infant, Very Low Birth Weight
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