Cited by 317Preterm Birth and ChorioamnionitisNeonatal and Maternal InfectionsReproductive tract infections research

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Bacteria and Inflammatory Cells in Fetal Membranes Do Not Always Cause Preterm Labor

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Steel, Jennifer H, Malatos, Sotiris, Kennea, Nigel, Edwards, A David, Miles, Lynda, Duggan, Philip, Reynolds, Peter R, Feldman, Robert G, Sullivan, Mark H F·2005·Pediatric Research

DOI 10.1203/01.pdr.0000153869.96337.90

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Abstract

Intrauterine infection has been frequently linked with preterm labor before 30 wk of human pregnancy. Many different species of organisms have been detected, leading to the suggestion that infection-induced preterm labor is a generic inflammatory response to organisms rather than a specific response to a limited number of pathogens. The detection of organisms by microbiological culture is a laborious and unreliable process, so the aim of this study was to harness modern molecular techniques to detect organisms in tissues from human pregnancy. A DNA probe specific for conserved regions of bacterial 16S ribosomal RNA sequence was designed and labeled with fluorescein for fluorescence in situ hybridization. Organisms were detected in the great majority (>80%) of fetal membranes after prolonged premature rupture of the fetal membranes and after preterm labor, which was consistent with previous data. Organisms were also detected in fetal membranes after preterm delivery without labor and in term deliveries (with or without labour). Inflammatory cells were found frequently in the amnion or chorion of preterm fetal membranes but not in term tissues. Our primary finding is that fluorescence in situ hybridization is an appropriate method to detect organisms in human fetal membranes. In addition, our data show that bacteria may be present in fetal membranes without necessarily causing an inflammatory response, so the mere presence of bacteria may not be sufficient to cause preterm labor.

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Authors: Steel, J. H., Malatos, S., Kennea, N., Edwards, A. D., Miles, L., Duggan, P., Reynolds, P. R., Feldman, R. G., & Sullivan, M. H. F.
Affiliations: Imperial College London (GB)
Hammersmith Hospital (GB)
Corresponding author: Sullivan, Mark H F
ORCID: Steel, Jennifer H
Kennea, Nigel
Edwards, A David
Reynolds, Peter R
Venue: Pediatric Research
Publisher: Springer Science and Business Media LLC
Published: 2005-03
Volume: 57
Issue: 3
Pages: 404-411
ISSN: 0031-3998 (ISSN-L)
1530-0447
DOI: 10.1203/01.pdr.0000153869.96337.90
OpenAlex: W2025568822
Cited by: 317
References: 52
Citations by year: 2026: 1 · 2025: 5 · 2024: 11 · 2023: 16 · 2022: 11 · 2021: 26 · 2020: 28 · 2019: 16 · 2018: 23 · 2017: 35 · 2016: 23 · 2015: 19 · 2014: 21 · 2013: 9 · 2012: 13
FWCI: 6.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Pediatric Research (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (publishedVersion, other-oa)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: preterm labor, fetal membranes, intrauterine infection, bacterial 16S rRNA, fluorescence in situ hybridization, bacterial detection, inflammatory cells, amniotic membrane, chorion, premature rupture of membranes, preterm birth, term pregnancy
MeSH terms: Bacteria, Female, Extraembryonic Membranes, Fetal Membranes, Premature Rupture, Premature Rupture of Fetal Membranes, Gestational Age, Humans, Immune System, Obstetric Labor, Premature, Pregnancy, RNA, Bacterial, RNA, Ribosomal, 16S, Nucleic Acid Probes, Antigens, CD, In Situ Hybridization, In Situ Hybridization, Fluorescence, Premature Birth

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Bacteria and Inflammatory Cells in Fetal Membranes Do Not Always Cause Preterm Labor

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