Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts
Open accessAbstract
Three advanced models of pharmacokinetics are described. In the first class are physiologically based pharmacokinetic models based on in vitro data on transport and metabolism. The information is translated as transporter and enzyme activities and their attendant heterogeneities into liver and intestine models. Second are circulatory models based on transit time distribution and plasma concentration time curves. The third are fractal models for nonhomogeneous systems and non-Fickian processes are presented. The usefulness of these pharmacokinetic models, with examples, is compared.
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Organ clearance is based on the loss of a parent drug across an organ of elimination.
“The concept of organ clearance is based on the loss of a parent drug across an organ of elimination [29,30,31,32].”
From Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling (2019) · cites this paper as [29]
Cites
The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms
West, G. B., Brown, J. H., & Enquist, B. J. (1999) · Science · doi:10.1126/science.284.5420.1677 · Cited by 1,718 · see citing works
Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01059688 · Cited by 797 · see citing works
Self-citationCoordinate transcriptional regulation of bile acid homeostasis and drug metabolism
Eloranta, J. J., & Kullak-Ublick, G. A. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.019 · Cited by 260 · see citing works
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Choi, G.-W., Lee, Y.-B., & Cho, H.-Y. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11040168 · Cited by 76 · see citing works
- Authors
- Pang, K. S., Weiss, M., & Macheras, P.
- Affiliations
- University of Toronto (CA)
- Martin Luther University Halle-Wittenberg (DE)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Pang, K. Sandy
- Venue
- The AAPS Journal
- Published
- 2007-06
- Volume
- 9
- Issue
- 2
- Pages
- E268-E283
- ISSN
- 1550-7416 (ISSN-L)
- PMC
- PMC2751417
- OpenAlex
- W2012792624
- Cited by
- 61
- References
- 3
- Citations by year
- 2026: 2 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 7
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The AAPS Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- pharmacokinetic modeling, circulatory model, fractal model, physiologically based pharmacokinetic modeling, enzyme heterogeneity, hepatic clearance, intestinal clearance, transit time distribution, plasma concentration-time curve, non-Fickian diffusion, inhomogeneous systems
- MeSH terms
- Animals, Blood Circulation, Pharmaceutical Preparations, Humans, Metabolic Clearance Rate, Models, Biological, Organ Specificity, Pharmacokinetics, Tissue Distribution
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