A Review of Clinical Translation of Inorganic Nanoparticles
Open accessAbstract
Inorganic nanoparticles are widely used for therapeutic and diagnostic purposes as they offer unique features as compared with their organic and polymeric counterparts. As such, inorganic nanoparticles represent an exciting opportunity to develop drug delivery and imaging systems that are poised to tackle unique challenges which are currently unaddressed in clinical settings. Despite these clear advantages, very few inorganic nanoparticle systems have entered the clinic. Here, we review the current clinical landscape of inorganic nanoparticle systems and their opportunities and challenges, with particular emphasis on gold-, iron-oxide- and silica-based nanoparticle systems. Key examples of inorganic nanoparticles that are currently being investigated in the clinic (e.g., trials which are recruiting or currently active but not completed) are highlighted, along with the preclinical work that these examples have leveraged to transition from the lab to the clinic.
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Polymeric nanoparticles are preferred over inorganic nanoparticles due to high biocompatibility, high biodegradability, and reduced systemic toxicity.
“However, polymeric nanoparticles are preferred over inorganic nanoparticles due to their high biocompatibility, high biodegradability, and reduced systemic toxicity.52”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [52]
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References 99 · Cited by 509
Research works printed but not linked: 2
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- Schoen C, London C. Pandia®. Nanotechnology for Biomed- ical Imaging and Diagnostics: John Wiley & Sons, Inc; 2014. p. 347-72.
- Authors
- Anselmo, A. C., & Mitragotri, S.
- Affiliations
- University of California, Santa Barbara (US)
- Corresponding author
- Mitragotri, Samir
- Venue
- The AAPS Journal
- Published
- 2015-05-09
- Volume
- 17
- Issue
- 5
- Pages
- 1041-1054
- ISSN
- 1550-7416 (ISSN-L)
- PMC
- PMC4540735
- OpenAlex
- W585675451
- Cited by
- 509
- References
- 99
- Citations by year
- 2026: 32 · 2025: 32 · 2024: 49 · 2023: 42 · 2022: 50 · 2021: 67 · 2020: 67 · 2019: 58 · 2018: 51 · 2017: 36 · 2016: 22 · 2015: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The AAPS Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1144085)
- University of California, Santa Barbara
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- inorganic nanoparticles, clinical translation, drug delivery, diagnostic imaging, gold nanoparticles, iron oxide nanoparticles, silica nanoparticles, clinical trials, translational research
- MeSH terms
- Animals, Diagnostic Imaging, Ferric Compounds, Gold, Humans, Silicon Dioxide, Drug Delivery Systems, Nanoparticles
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