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Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery
Open accessAbstract
Shortage of functional groups on surface of poly(lactide-co-glycolide) (PLGA)-based drug delivery carriers always hampers its wide applications such as passive targeting and conjugation with targeting molecules. In this research, PLGA nanoparticles were modified with chitosan through physical adsorption and chemical binding methods. The surface charges were regulated by altering pH value in chitosan solutions. After the introduction of chitosan, zeta potential of the PLGA nanoparticle surface changed from negative charge to positive one, making the drug carriers more affinity to cancer cells. Functional groups were compared between PLGA nanoparticles and chitosan-modified PLGA nanoparticles. Amine groups were exhibited on PLGA nanoparticle surface after the chitosan modification as confirmed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The modified nanoparticles showed an initial burst release followed by a moderate and sustained release profile. Higher percentage of drugs from cumulative release can be achieved in the same prolonged time range. Therefore, PLGA nanoparticles modified by chitosan showed versatility of surface and a possible improvement in the efficacy of current PLGA-based drug delivery system.
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“Common materials like PLGA and chitosan are often used in NP formulations because they break down naturally in the body into non-toxic byproducts, making them safer for medical and therapeutic applications [171].”
From Targeted Nanoparticles for Drug Delivery Across the Blood–Brain Barrier in Early and Late Stages of Alzheimer's Disease: A Review (2026) · cites this paper as [171]
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“Therefore, the increased EE and DL of coated liposomes could be attributed to the interaction between positively charged CS and negatively charged 5-FU, leading to more 5-FU molecules on the surface of chitosomes (Wang et al., 2013).”
From The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer (2019) · cites this paper as Wang et al., 2013
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Metadata
- Authors
- Wang, Y., Li, P., & Kong, L.
- Affiliations
- Deakin University (AU)
- Chinese Academy of Tropical Agricultural Sciences (CN)
- Corresponding author
- Kong, Lingxue
- Venue
- AAPS PharmSciTech
- Published
- 2013-03-06
- Volume
- 14
- Issue
- 2
- Pages
- 585-592
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC3665987
- OpenAlex
- W2100809064
- Cited by
- 305
- References
- 30
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 34 · 2023: 31 · 2022: 32 · 2021: 24 · 2020: 31 · 2019: 27 · 2018: 17 · 2017: 22 · 2016: 20 · 2015: 14 · 2014: 7 · 2013: 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- PLGA nanoparticles, chitosan modification, surface functionalization, drug carriers, zeta potential, pH-dependent surface charge, amino groups, drug release kinetics, sustained drug release, tumor targeting, physisorption, chemical conjugation
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Antimetabolites, Antineoplastic, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Carriers, Fluorouracil, Hydrogen-Ion Concentration, Kinetics, Polyglycolic Acid, Solubility, Surface Properties, Technology, Pharmaceutical, Spectroscopy, Fourier Transform Infrared, Lactic Acid, Nanotechnology, Chitosan, Nanoparticles, Photoelectron Spectroscopy
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