Polymeric micelles: nanocarriers for cancer-targeted drug delivery
Open accessAbstract
Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs. With small size (10-100 nm) and hydrophilic shell of PEG, polymeric micelles exhibit prolonged circulation time in the blood and enhanced tumor accumulation. In this review, the importance of rational design was highlighted by summarizing the recent progress on the development of micellar formulations. Emphasis is placed on the new strategies to enhance the drug/carrier interaction for improved drug-loading capacity. In addition, the micelle-forming drug-polymer conjugates are also discussed which have both drug-loading function and antitumor activity.
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References 133 · Cited by 367
Part of this paper’s reference list could not be split into single entries.
Research works printed but not linked: 3
- Nie S, Xing Y, Kim GJ, Simons JW. Nanotechnology applica- tions in cancer. Annu Rev Biomed Eng. 2007;9:257-88.
- Weissig V, Whiteman KR, Torchilin VP. Accumulation of pro- tein-loaded long-circulating micelles and liposomes in subcuta- neou s Lewis lu ng carcinom a i n mice. Pharm Res. 1998;15(10):1552-6.
- Torchilin VP. Micellar nanocarriers: pharmaceutical perspec- tives. Pharm Res. 2007;24(1):1-16.
- Authors
- Zhang, Y., Huang, Y., & Li, S.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Li, Song
- Venue
- AAPS PharmSciTech
- Published
- 2014-04-04
- Volume
- 15
- Issue
- 4
- Pages
- 862-871
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC4113619
- OpenAlex
- W2081833688
- Cited by
- 367
- References
- 133
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 46 · 2023: 38 · 2022: 61 · 2021: 47 · 2020: 37 · 2019: 32 · 2018: 25 · 2017: 22 · 2016: 14 · 2015: 2 · 2014: 1
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA174305, R21CA173887)
- National Institute of General Medical Sciences (R01GM102989)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polymeric micelles, anticancer drug delivery, PEGylation, drug loading capacity, polymer-drug conjugates, nanocarriers
- MeSH terms
- Antineoplastic Agents, Chemistry, Pharmaceutical, Drug Carriers, Humans, Micelles, Neoplasms, Polymers, Drug Delivery Systems
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