The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Nanoemulsion for Solubilization, Stabilization, and In Vitro Release of Pterostilbene for Oral Delivery
Open accessAbstract
Pterostilbene, being extracted from many plants, has significant biological activities in preventing cancer, diabetes, and cardiovascular diseases so as to have great potential applications in pharmaceutical fields. But the poor solubility and stability of pterostilbene strictly restrained its applications. As a good protection and oral delivery system, an optimal nanoemulsion for pterostilbene was developed by using low-energy emulsification method. Systematic pseudo-ternary phase diagrams have been studied in optimization of nanoemulsion formulations. The prepared pterostilbene nanoemulsion was characterized by transmission electron microscope, Fourier transform Raman spectrum, and laser droplet size analyzer. Nanoemulsion droplets are circular with smooth margin, and the mean size is 55.8 ± 10.5 nm. The results illustrated that the nanoemulsion as oral delivery system dramatically improved the stability and solubility of pterostilbene, and in vitro release of pterostilbene was significantly improved (96.5% in pH 3.6 buffer; 13.2% in pH 7.4 buffer) in comparison to the pterostilbene suspension (lower than 21.4% in pH 3.6 buffer; 2.6% in pH 7.4 buffer).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Co-surfactants, such as polyethylene glycol, ethylene glycol, propylene glycol, ethanol and glycerine can be used for the stabilization of NEs [45].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [45]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nano-emulsions: New applications and optimization of their preparation
Gutiérrez, J. M., González, C., Maestro, A., Solé, I., Pey, C., & Nolla, J. (2008) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2008.01.005 · Cited by 631
Oil-in-water nanoemulsions for pesticide formulations
Wang, L., Li, X., Zhang, G., Dong, J., & Eastoe, J. (2007) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2007.04.079 · Cited by 464
Design and optimization of a new self-nanoemulsifying drug delivery system
Wang, L., Dong, J., Chen, J., Eastoe, J., & Li, X. (2008) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2008.10.077 · Cited by 409
Nonionic oil-in-water microemulsions: the effect of oil type on phase behaviour
Warisnoicharoen, W., Lansley, A. B., & Lawrence, M. J. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00406-8 · Cited by 268
Stilbene Content of Mature Vitis vinifera Berries in Response to UV-C Elicitation
Adrian, M., Jeandet, P., Breuil, A.-C., Tesson, L., & Bessis, R. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0009910 · Cited by 264
Bali, V., Ali, M., & Ali, J. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.11.021 · Cited by 263
Identification of pterostilbene as a phytoalexin from Vitis vinifera leaves
Langcake, P., Cornford, C. A., & Pryce, R. J. (1979) · Phytochemistry · doi:10.1016/s0031-9422(00)91470-5 · Cited by 223
Studies of formation of W/O nano-emulsions
Porras, M., Solans, C., González, C., Martínez, A., Guinart, A., & Gutiérrez, J. M. (2004) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2004.08.060 · Cited by 206
Chiou, Y.-S., Tsai, M.-L., Nagabhushanam, K., Wang, Y.-J., Wu, C., Ho, C., & Pan, M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2000103 · Cited by 205
Uson, N., García, M. J. N., & Solans, C. (2004) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2004.03.039 · Cited by 181
Tolomeo, M., Grimaudo, S., Cristina, A. D., Roberti, M., Pizzirani, D., Meli, M., Dusonchet, L., Gebbia, N., Abbadessa, V., Crosta, L., et al. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.004 · Cited by 162
Association between Pterostilbene and Quercetin Inhibits Metastatic Activity of B16 Melanoma
Ferrer, P., Asensi, M. A., Segarra, R., Ortega, Á., Benlloch, M., Obrador, E., Varea, T., Asensio, G., Jordá, L., & Estrela, J. M. (2005) · Neoplasia · doi:10.1593/neo.04337 · Cited by 159
Pterostilbene Induces Apoptosis and Cell Cycle Arrest in Human Gastric Carcinoma Cells
Pan, M., Chang, Y.-H., Badmaev, V., Nagabhushanam, K., & Ho, C. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071520h · Cited by 156
114. An investigation of the Gibbs reaction and its bearing on the constitution of jacareubin
King, F. E., King, T. J., & Manning, L. C. (1957) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9570000563 · Cited by 147
Szebeni, J., Alving, C. R., Sávay, S., Barenholz, Y., Priev, A., Danino, D., & Talmon, Y. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00006-6 · Cited by 145
Paul, B., Masih, I. E., Deopujari, J. Y., & Charpentier, C. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(99)00044-6 · Cited by 142
HPLC Analysis of Grapevine Phytoalexins Coupling Photodiode Array Detection and Fluorometry
Jeandet, P., Breuil, A.-C., Adrian, M., Weston, L. A., Debord, S., Meunier, P., Maume, G., & Bessis, R. (1997) · Analytical Chemistry · doi:10.1021/ac970582b · Cited by 141
Polyphenols of Pterocarpus and Dalbergia woods
Seshadri, T. R. (1972) · Phytochemistry · doi:10.1016/s0031-9422(00)88430-7 · Cited by 129
Making homogeneous and fine droplet O/W emulsions using nonionic surfactants
Sagitani, H. (1981) · Journal of the American Oil Chemists Society · doi:10.1007/bf02899466 · Cited by 87
Formation and properties of miniemulsions formed by microemulsions dilution
Pons, R., Carrera, I., Caelles, J., Rouch, J., & Panizza, P. (2003) · Advances in Colloid and Interface Science · doi:10.1016/s0001-8686(03)00108-8 · Cited by 81
Hougee, S., Faber, J., Sanders, A., de Jong, R. B., van den Berg, W. B., Garssen, J., Hoijer, M. A., & Smit, H. F. (2005) · Planta Medica · doi:10.1055/s-2005-864130 · Cited by 75
Lamaallam, S., Bataller, H., Dicharry, C., & Lachaise, J. (2005) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2005.05.035 · Cited by 68
Dai, L., Li, W., & Hou, X. (1997) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/s0927-7757(96)03859-9 · Cited by 68
Pterostilbene Inhibits Lung Cancer Through Induction of Apoptosis
Schneider, J. G., Alosi, J. A., McDonald, D. E., & McFadden, D. W. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.06.027 · Cited by 65
Ghisalberti, E. L., Jefferies, P. R., Lanteri, R., & Matisons, J. (1978) · Cellular and Molecular Life Sciences · doi:10.1007/bf01944648 · Cited by 54
Low energy nanoemulsification to design veterinary controlled drug delivery devices
Vandamme, T., & Anton, N. (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s13273 · Cited by 50
An Excellent Delivery System for Improving the Oral Bioavailability of Natural Vitamin E in Rats
Gong, Y.-H., Wu, Y.-K., Zheng, C., Fan, L.-Y., Xiong, F., & Zhu, J.-B. (2012) · AAPS PharmSciTech · doi:10.1208/s12249-012-9819-y · Cited by 47
Lee, M., Pan, M., Chiou, Y., Cheng, A., & Huang, H. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202426k · Cited by 44
Perečko, T., Drábiková, K., Račková, L., Čı́ž, M., Podborská, M., Lojek, A., Harmatha, J., Šmidrkal, J., Nosáľ, R., & Jančinová, V. (2010) · PubMed · Cited by 41
Preparation, Characterization and Cytotoxicity Evaluation of Tanshinone IIA Nanoemulsions
Chang, L.-C., Wu, C.-L., Liu, C.-W., Chuo, W., Li, P., & Tsai, T. (2011) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2011.1315 · Cited by 35
Kometiani, P. A., Liu, L., & Askari, A. (2004) · Cited by 35
Elnaggar, Y. S., Massik, M. A. E., & Abdallah, O. (2011) · International Journal of Nanotechnology · doi:10.1504/ijnt.2011.041443 · Cited by 34
Design and Evaluation of Self-Nanoemulsifying Pellets of Repaglinide
Desai, N., & Nagarsenker, M. S. (2013) · AAPS PharmSciTech · doi:10.1208/s12249-013-9990-9 · Cited by 31
Über die Inhaltsstoffe des roten Sandelholzes. II. Mitteil.: Die Konstitution des Pterostilbens
Späth, E., & Schläger, J. (1940) · Berichte der deutschen chemischen Gesellschaft (A and B Series) · doi:10.1002/cber.19400730808 · Cited by 29
Transmission of Visible and Ultraviolet Light through Charge-Stabilized Nanoemulsions
Graves, S. M., & Mason, T. G. (2008) · The Journal of Physical Chemistry C · doi:10.1021/jp801019z · Cited by 28
[Studies on the chemical constituents of chloroform extract of Dracaena cochinchinensis].
Lu, W.-J., Wang, L., Chen, J., Yang, L., Wu, N., Kang, W., & Zheng, Q. (1998) · PubMed · Cited by 19
Development and In Vitro Characterizations of Bifendate Nanosuspensions
Liu, Y., Zhang, D., Zou, D., Wang, Y., Duan, C., Jia, L., Xie, P., Feng, F., Wang, F., Zhang, X.-S., et al. (2011) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2011.1330 · Cited by 13
Preparation and Evaluation of O/W Pharmaceutical Microemulsions
Genxin, L., Zhang, J., Peixing, W., Li, J., Liu, Y., Xuzheng, Z., Wei, X., JianRong, N., & Li, B. (2009) · Zhongguo nongye Kexue · Cited by 1
Research works printed but not linked: 3
- Mathew J, Rao A. Chemical examination of Pterocarpus marsupium. J Indian Chem Soc. 1984;61:728–9.
- Rimando A, Cody R. Determination of stilbenes in blueberries. LCGC North America. 2005;23:1192, 1194, 1196, 1198, 1200.
- Pan G, Jia X, Wei H. Comparison among several preparation methods for pseudo-ternary phase diagrams of pharmaceutical microemulsions. J Chin Pharm. 2006;17:21–3.
Cited by
Sorted by citations
Nanoemulsion: Concepts, development and applications in drug delivery
Singh, Y., Meher, J. G., Raval, K., Khan, F. A., Chaurasia, M., Jain, N. K., & Chourasia, M. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.008 · Cited by 1,358
Biological Activities of Stilbenoids
Akinwumi, B. C., Bordun, K.-A., & Anderson, H. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030792 · Cited by 392
Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
Preeti, Sambhakar, S., Malik, R., Bhatia, S., Al‐Harrasi, A., Rani, C., Saharan, R., Kumar, S. S., Geeta, G., & Sehrawat, R. (2023) · Scientifica · doi:10.1155/2023/6640103 · Cited by 343
Anti-inflammatory activity of natural stilbenoids: A review
Dvořáková, M., & Landa, P. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.002 · Cited by 280
Nanoemulsions for “Nose-to-Brain” Drug Delivery
Bonferoni, M. C., Rossi, S., Sandri, G., Ferrari, F., Gavini, E., Rassu, G., & Giunchedi, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020084 · Cited by 269
Metadata
- Authors
- Zhang, Y., Shang, Z., Gao, C., Du, M., Xu, S., Song, H., & Liu, T.
- Affiliations
- Hebei University of Science and Technology (CN)
- Corresponding author
- Shang, Zhenhua
- Venue
- AAPS PharmSciTech
- Published
- 2014-05-15
- Volume
- 15
- Issue
- 4
- Pages
- 1000-1008
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC4113613
- OpenAlex
- W1989051754
- Cited by
- 118
- References
- 40
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 16 · 2023: 19 · 2022: 8 · 2021: 15 · 2020: 19 · 2019: 14 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hebei University of Science and Technology
- Hebei University
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- pterostilbene, nanoemulsions, oral drug delivery, solubilization, drug stability, in vitro drug release, pseudo-ternary phase diagram, low-energy emulsification, poorly water-soluble drugs
- MeSH terms
- Administration, Oral, Biological Availability, Chemistry, Pharmaceutical, Drug Carriers, Drug Stability, Emulsions, Particle Size, Solubility, Stilbenes, Suspensions, Drug Delivery Systems, Nanoparticles, Drug Liberation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
