The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Assessing the In Vitro Drug Release from Lipid-Core Nanocapsules: a New Strategy Combining Dialysis Sac and a Continuous-Flow System
Open accessAbstract
The in vitro assessment of drug release from polymeric nanocapsules suspensions is one of the most studied parameters in the development of drug-loaded nanoparticles. Nevertheless, official methods for the evaluation of drug release from submicrometric carriers are not available. In this work, a new approach to assess the in vitro drug release profile from drug-loaded lipid-core nanocapsules (LNC) was proposed. A continuous-flow system (open system) was designed to evaluate the in vitro drug release profiles from different LNC formulations containing prednisolone or clobetasol propionate (LNC-CP) as drug model (LNC-PD) using a homemade apparatus. The release medium was constantly renewed throughout the experiment. A dialysis bag containing 5 mL of formulation (0.5 mg mL(-1)) was maintained inside the apparatus, under magnetic stirring and controlled temperature (37°C). In parallel, studies based on the conventional dialysis sac technique (closed system) were performed. It was possible to discriminate the in vitro drug release profile of different formulations using the open system. The proposed strategy improved the sink condition, by constantly renewing the release medium, thus maintaining the drug concentration farther from the saturated concentration in the release medium. Moreover, problems due to sampling errors can be easily overcome using this semi-automated system, since the collection is done automatically without interference from the analyst. The system proposed in this paper brings important methodological and analytical advantages, becoming a promising prototype semi-automated apparatus for performing in vitro drug release studies from drug-loaded lipid-core nanocapsules and other related nanoparticle drug delivery systems.
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“Additionally, when micelles are designed to provide a targeted delivery in specific environmental conditions, these studies are fundamental for confirming the effective release of the drug in the presence of the triggering stimulus [115].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [115]
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“Drug release studies can also be used as a proof-of-concept of the stimuli-responsiveness of the micellar systems.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [115]
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“Stimuli that change micelles structure and trigger drug release are for instance pH (typically lower in endosomes/lysosomes, in tumor cells and in inflamed tissues), presence of reducing agents (such as glutathione, whose level is quite elevated in some tumors), specific enzymes (for instance matrix metalloproteinases overexpressed at tumor sites or matrix metalloproteinases-13, overexpressed in o”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [115]
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Citations
Cites
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Nanotechnology in Therapeutics: A Focus on Nanoparticles as A Drug Delivery System
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Self-citationMethods to Assess in Vitro Drug Release from Injectable Polymeric Particulate Systems
D’Souza, S. S., & DeLuca, P. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-005-9397-8 · Cited by 293
Phillips, D. J., Pygall, S. R., Cooper, V. B., & Mann, J. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01523.x · Cited by 223
Formulation of lipid core nanocapsules
Venturini, C. G., Jäger, E., de Oliveira, C. P., et al. (2010) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2010.12.011 · Cited by 171
A novel USP apparatus 4 based release testing method for dispersed systems
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Self-citationWhat is a Suitable Dissolution Method for Drug Nanoparticles?
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Cited by
Sorted by citations
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135
Metadata
- Authors
- de Andrade, D. F., Zuglianello, C., Pohlmann, A. R., Guterres, S. S., & Beck, R. C. R.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Beck, Ruy Carlos Ruver
- Venue
- AAPS PharmSciTech
- Published
- 2015-05-19
- Volume
- 16
- Issue
- 6
- Pages
- 1409-1417
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC4666260
- OpenAlex
- W312266247
- Cited by
- 43
- References
- 28
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Ministério da Ciência, Tecnologia e Inovação
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- lipid-core nanocapsules, in vitro drug release, dialysis bags, sink conditions, prednisolone, clobetasol propionate, drug-loaded nanoparticles, nanoparticle drug delivery
- MeSH terms
- Chemistry, Pharmaceutical, Clobetasol, Drug Carriers, Renal Dialysis, Lipids, Polymers, Drug Delivery Systems, Nanocapsules, Drug Liberation
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