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Cited by 32Gestational Diabetes Research and ManagementDiabetes Management and ResearchPregnancy and Medication Impact

Gestational Diabetes: An Update 60 Years After O’Sullivan and Mahan

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McIntyre, Harold David, Kampmann, Ulla, Dalsgaard Clausen, Tine, Laurie, Josephine, Ma, Ronald Ching Wan·2024·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/clinem/dgae709PMC PMC11651698
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Abstract

Sixty years after the landmark publication by O'Sullivan and Mahan, the current paper seeks to review and place into context the importance of gestational diabetes (GDM) both as a marker of increased risk of adverse maternal and fetal pregnancy outcomes and as an indicator of future maternal and infant health risks. We review the evolution of GDM as a diagnosis, the ongoing debate regarding diagnostic approaches, the underlying pathophysiology, and the epidemiology and the importance of GDM in the context of the global epidemics of diabetes and obesity. Focusing on clinical management, we review lifestyle-based therapy and pharmacotherapy for GDM, consider obstetric management, and outline the short-term and lifelong health risks posed by a GDM diagnosis.

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  • GDM is the most common pregnancy complication.

    “Nowadays, GDM is the most common pregnancy complication; its prevalence is elevated in Western world areas, partly because of increasing obesity rates and maternal age, leading to side effects in the short and long term [29].”

    From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [29]

    The Epidemiology section reports that GDM prevalence ranges from about 1% to over 20% and gives a pooled global estimate of 14.0%, supporting that it is a common condition in pregnancy. It does not compare GDM with other pregnancy complications or establish that it is the most common. (LLM, conf=0.79)

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References 149 · Cited by 32

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Authors
McIntyre, H. D., Kampmann, U., Dalsgaard Clausen, T., Laurie, J., & Ma, R. C. W.
Affiliations
  • Mater Research, Faculty of Medicine, The University of Queensland , South Brisbane, QLD 4101 ,
  • Aarhus University (DK)
  • Department of Gynecology, Fertility and Obstetrics, Center for Pregnant Women with Diabetes , 2100 Copenhagen Ø ,
  • The University of Queensland (AU)
  • Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital ,
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2024-10-11
Volume
110
Issue
1
Pages
e19-e31
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/clinem/dgae709
PMC
PMC11651698
OpenAlex
W4403284945
Cited by
32
References
149
Citations by year
2026: 18 · 2025: 14
FWCI
2.97
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
  • Scopus (Elsevier) (submittedVersion, cc-by)
Funders
  • Research Grants Council of the Hong Kong SAR, China (14118718, 14102719)
  • The Novo Nordisk Foundation
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
gestational diabetes mellitus, GDM diagnosis, maternal and fetal outcomes, long-term health risks, lifestyle therapy, pharmacotherapy, obstetric management, diabetes epidemic, obesity
MeSH terms
Female, Humans, Pregnancy, Pregnancy Outcome, Diabetes, Gestational, History, 20th Century, History, 21st Century

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