The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Adrenomedullin, a Multifunctional Regulatory Peptide*
Abstract
Since the discovery of adrenomedullin in 1993 several hundred papers have been published regarding the regulation of its secretion and the multiplicity of its actions. It has been shown to be an almost ubiquitous peptide, with the number of tissues and cell types synthesizing adrenomedullin far exceeding those that do not. In Section II of this paper we give a comprehensive review both of tissues and cell lines secreting adrenomedullin and of the mechanisms regulating gene expression. The data on circulating adrenomedullin, obtained with the various assays available, are also reviewed, and the disease states in which plasma adrenomedullin is elevated are listed. In Section III the pharmacology and biochemistry of adrenomedullin binding sites, both specific sites and calcitonin gene-related peptide (CGRP) receptors, are discussed. In particular, the putative adrenomedullin receptor clones and signal transduction pathways are described. In Section IV the various actions of adrenomedullin are discussed: its actions on cellular growth, the cardiovascular system, the central nervous system, and the endocrine system are all considered. Finally, in Section V, we consider some unresolved issues and propose future areas for research.
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Cites
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
McLatchie, L. M., Fraser, N. J., Main, M. J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M. G., & Foord, S. M. (1998) · Nature · doi:10.1038/30666 · Cited by 2,134
Intraadrenal interactions in the regulation of adrenocortical steroidogenesis.
Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., & Vinson, G. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0326 · Cited by 600
Self-citationChang, C.-P., Pearse, R. V., O'Connell, S., & Rosenfeld, M. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90230-o · Cited by 537
Amylin, Calcitonin Gene-Related Peptide, Calcitonin, and Adrenomedullin: A Peptide Superfamily
Wimalawansa, S. J. (1997) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v11.i2-3.40 · Cited by 424
A Human Orphan Calcitonin Receptor-like Structure
Fluhmann, B., Muff, R., Hunziker, W., Fischer, J. A., & Born, W. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1047 · Cited by 132
Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo
Cornish, J., Callon, K. E., Coy, D. H., Jiang, N.-Y., Xiao, L., Cooper, G. J. S., & Reid, I. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1113 · Cited by 96
Cited by
Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A., & Foord, S. M. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.233 · Cited by 804
Self-citationVascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
Brain, S. D., & Grant, A. D. (2004) · Physiological Reviews · doi:10.1152/physrev.00037.2003 · Cited by 765
Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay
Morgenthaler, N. G., Struck, J., Alonso, C., & Bergmann, A. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.051110 · Cited by 399
Caron, K. M., & Smithies, O. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.615 · Cited by 346
Potential markers of preeclampsia – a review
Grill, S., Rusterholz, C., Zanetti-Dällenbach, R., Tercanli, S., Holzgreve, W., Hahn, S., & Lapaire, O. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-70 · Cited by 293
Metadata
- Authors
- Hinson, J. P., Kapas, S., & Smith, D. M.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2000-04-01
- Volume
- 21
- Issue
- 2
- Pages
- 138-167
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2104583114
- Cited by
- 752
- References
- 6
- FWCI
- 18.03
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
