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The effect of hypothyroidism on Sertoli cell proliferation and differentiation and hormone levels during testicular development in the rat
Abstract
In this study we show that 6-propyl-2-thiouracil (PTU) treatment of Wistar rats from birth up to day 26 p.p. retards the morphological differentiation of Sertoli cells, and prolongs the proliferation of these cells up to day 30. Sertoli cell numbers per testis, determined at day 36, were increased by 84% compared to controls. PTU treatment increased serum thyroid-stimulating hormone (TSH) levels and reduced serum levels of thyroxine (T4) from 5 days onwards, indicative of severe hypothyroidism. Follicle-stimulating hormone (FSH) levels were reduced from day 5 to 9, normal at day 12 and 16, and reduced again from day 20 to 36. Inhibin levels were decreased from day 9 to 20 and increased at 36 days of age. The increase in the number of Sertoli cells per testis in PTU treated rats, as has been reported in the present study, is likely to be responsible for the increased testis size observed by other groups (1) in these animals, when adult.
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Citations
Cited by
Thyroid Function and Human Reproductive Health
Krassas, G. E., Poppe, K., & Glinoer, D. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0041 · Cited by 1,223
de Kretser, D. M., Loveland, K. L., Meinhardt, A., Simorangkir, D., & Wreford, N. (1998) · Human Reproduction · doi:10.1093/humrep/13.suppl_1.1 · Cited by 466
Metadata
- Authors
- van Haaster, L. H., de Jong, F. H., Docter, R., & de Rooij, D. G.
- Venue
- Endocrinology
- Publisher
- Oxford University Press
- Published
- 1992-09-01
- Volume
- 131
- Issue
- 3
- Pages
- 1574-1576
- ISSN
- 0013-7227 (ISSN-L)
- OpenAlex
- W1967279915
- Cited by
- 200
- References
- 0
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The effect of hypothyroidism on Sertoli cell proliferation and differentiation and hormone levels during testicular development in the rat. https://app.cochat.ai/papers/10.1210/en.131.3.1574
- The paper
- van Haaster, L. H., de Jong, F. H., Docter, R., & de Rooij, D. G. (1992). The effect of hypothyroidism on Sertoli cell proliferation and differentiation and hormone levels during testicular development in the rat. Endocrinology. https://doi.org/10.1210/en.131.3.1574
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
