The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats1
Abstract
Endocrine responses to noise stress and anxiety-related behaviors were measured in groups of ovariectomized, estradiol-treated female rats given central infusions of oxytocin. Control animals receiving isotonic saline showed a large increase in plasma corticosterone concentrations in response to 10 min of white noise. This response to noise stress was significantly and dose dependently decreased by oxytocin administered intracerebroventricularly at 10 or 100 ng/h for 5 days. Oxytocin also significantly decreased rearing behavior during this stress. When a second noise stress was given 3 days after cessation of oxytocin infusion, corticosterone responses did not differ between the control and previously oxytocin-infused animals. Administration of vasopressin had no significant effect on either the corticosterone or behavioral responses to noise stress. Anxiety-related behaviors were measured on the elevated plus-maze. No significant differences were seen in maze exploration between saline- and oxytocin-treated animals when housed and tested in the same environment. However, when animals were mildly stressed by testing in an unfamiliar environment, oxytocin-treated animals showed a higher proportion of open arm entries and spent significantly more time in the open arms of the maze. Thus, oxytocin exerts a central anxiolytic-like effect on both endocrine and behavioral systems and could play a role in moderating behavioral and physiological responses to stress.
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“Although OT can act at the pituitary to enhance CRH action, when delivered to the PVN, OT decreased HPA axis gain, as shown by decreased CORT and ACTH levels (Neumann, Krömer, Toschi, & Ebner, 2000; Windle et al., 2004; Windle, Shanks, Lightman, & Ingram, 1997).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Windle, Shanks, Lightman, & Ingram, 1997
In the citing paper
“Because AVP typically enhances (Landgraf et al., 1995; Beiderbeck et al., 2007) while OXT reduces (Windle et al., 1997; Ring et al., 2006; Blume et al., 2008) anxiety-like behaviors of rats exposed to novel environments”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Windle et al., 1997
In the citing paper
“For years, OXT agonists have been shown to be effective in animal models of anxiety (Windle et al, 1997).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Windle et al, 1997
In the citing paper
“So, not only is Oxt able to acutely regulate stress responses (81, 82) but appears to also be involved in the development of long-term responsiveness to stress.”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [81]
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Metadata
- Authors
- Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D.
- Affiliations
- Bristol Royal Infirmary (GB)
- Corresponding author
- Windle, R. J.
- ORCID
- Windle, R. J.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1997-07
- Volume
- 138
- Issue
- 7
- Pages
- 2829-2834
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W4248942370
- Cited by
- 170
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 12
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, corticosterone, stress response, anxiety, noise stress, vasopressin, anxiolytic effects, elevated plus maze, rearing behavior, estradiol, ovariectomy, hypothalamic-pituitary-adrenal axis, central nervous system
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