Neuropeptide Y1 and Y5 Receptors Mediate the Effects of Neuropeptide Y on the Hypothalamic-Pituitary-Thyroid Axis
Abstract
Neuropeptide Y (NPY) is one of the most important hypothalamic-derived neuropeptides mediating the effects of leptin on energy homeostasis. Central administration of NPY not only markedly stimulates food intake, but simultaneously inhibits the hypothalamic-pituitary-thyroid axis (HPT axis), replicating the central hypothyroid state associated with fasting. To identify the specific NPY receptor subtypes involved in the action of NPY on the HPT axis, we studied the effects of the highly selective Y1 ([Phe7,Pro34]pNPY) and Y5 ([chicken pancreatic polypeptide1–7, NPY19–23, Ala31, Aib32 (aminoisobutyric acid), Q34]human pancreatic polypeptide) receptor agonists on circulating thyroid hormone levels and proTRH mRNA in hypophysiotropic neurons of the hypothalamic paraventricular nucleus. The peptides were administered continuously by osmotic minipump into the cerebrospinal fluid (CSF) over 3 d in ad libitum-fed animals and animals pair-fed to artificial CSF (aCSF)-infused controls. Both Y1 and Y5 receptor agonists nearly doubled food intake compared with that of control animals receiving aCSF, similar to the effect observed for NPY. NPY, Y1, and Y5 receptor agonist administration suppressed circulating levels of thyroid hormones (T3 and T4) and resulted in inappropriately normal or low TSH levels. These alterations were also associated with significant suppression of proTRH mRNA in the paraventricular nucleus, particularly in the Y1 receptor agonist-infused group [aCSF, NPY, Y1, and Y5 (density units ± sem), 97.2 ± 8.6, 39.6 ± 8.4, 19.9 ± 1.9, and 44.6 ± 8.4]. No significant differences in thyroid hormone levels, TSH, or proTRH mRNA were observed between the agonist-infused FSanimals eating ad libitum and the agonist-infused animals pair-fed with vehicle-treated controls. These data confirm the importance of both Y1 and Y5 receptors in the NPY-mediated increase in food consumption and demonstrate that both Y1 and Y5 receptors can mediate the inhibitory effects of NPY on the HPT axis.
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NPY also regulates the HPT axis.
“it is well known that NPY also regulates the HPT axis (56).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [56]
NPY's inhibitory action on hypophysiotropic TRH neurons is mediated primarily through Y1 and Y5 receptors.
“The inhibitory effects of NPY on hypophysiotropic TRH neurons are mediated primarily by Y 1 and Y 5 receptors because the central administration of either selective Y1 or Y5 receptor agonist is equally effective in inhibiting hypophysiotropic TRH gene expression and the HPT axis (162).”
From Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions (2014) · cites this paper as [162]
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References 34 · Cited by 79
- Authors
- Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., Beck-Sickinger, A., & Lechan, R. M.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Tufts Medical Center (US)
- Tufts University (US)
- Brigham and Women's Hospital (US)
- University of Massachusetts Chan Medical School (US)
- Institute of Biochemistry, University of Leipzig (A.B.-S.), Leipzig 04103, Germany
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2002-12-01
- Volume
- 143
- Issue
- 12
- Pages
- 4513-4519
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2158560926
- Cited by
- 79
- References
- 34
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 8 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA 10732, R01DA010732)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 37021, DK 58538)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- neuropeptide Y, Y1 receptor, Y5 receptor, hypothalamic-pituitary-thyroid axis, thyroid hormones, thyroid-stimulating hormone, paraventricular nucleus, dietary intake, energy homeostasis, leptin, central hypothyroidism, pancreatic polypeptide, receptor agonists, cerebrospinal fluid
- MeSH terms
- Uncoupling Protein 1, Adipose Tissue, Animals, Body Weight, Adipose Tissue, Brown, Carrier Proteins, Eating, Hypothalamus, Ion Channels, Male, Membrane Proteins, Neuropeptide Y, Organ Size, Paraventricular Hypothalamic Nucleus, Pituitary Gland, Protein Precursors, RNA, Messenger, Thyroid Gland, Thyrotropin-Releasing Hormone, Thyroxine, Triiodothyronine, Rats, Sprague-Dawley, Receptors, Neuropeptide Y, Mitochondrial Proteins, Rats
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