Human Placental Growth Hormone Increases Expression of the P85 Regulatory Unit of Phosphatidylinositol 3-Kinase and Triggers Severe Insulin Resistance in Skeletal Muscle

Barbour, Linda A., Shao, Jianhua, Qiao, Liping, Leitner, Wayne, Anderson, Marianne, Friedman, Jacob E., Draznin, Boris·2004·Endocrinology

DOI 10.1210/en.2003-1297

Cited by (208)

Items 101–200 of 208

Endogenous SHBG levels correlate with that of glucose transporters in insulin resistance model cells
Chong Feng, Zhen Jin, Lei Sun, Xiaoyan Wang, Xinshu Chi, Xuan Zhang, Siyu Lian · 2019 · Molecular Biology Reports
Growth hormone binding protein and maternal body mass index in relation to placental growth hormone and insulin requirements during pregnancy in type 1 diabetic women
Jens Fuglsang, Finn Friis Lauszus, Sanne Fisker, Allan Flyvbjerg, Per Ovesen · 2005 · Growth Hormone & IGF Research
Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling
Thue Johansen, C. Laurino, A. Barreca, Kjell Malmlöf · 2005 · Growth Hormone & IGF Research
Metformin downregulates miR223 expression in insulin-resistant 3T3L1 cells and human diabetic adipose tissue
Yousof Naghiaee, Reza Didehdar, Fatemeh Pourrajab, Masoud Rahmanian, Naeimeh Heiranizadeh, Azra Mohiti, Javad Mohiti-Ardakani · 2020 · Endocrine
Metabolic control of feto–placental development and pregnancy outcomes
Yuanfeng Gao, Xin Yu, Yuefan Wang, Hongmei Wang, Yanling Wang, Ng Shyh‐Chang · 2025 · Nature Reviews Endocrinology
Modelling gestational diabetes mellitus: large animals hold great promise
Xiang Gao, Junsheng He, Anming Zhu, Kang Xie, Kaixuan Yan, Xue Xiang Jiang, Ying Xu, Qin Li, Aimin Xu, Dewei Ye et al. · 2020 · Reviews in Endocrine and Metabolic Disorders
The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy
Wendy Nokhwezi Phoswa · 2021 · Frontiers in Cardiovascular Medicine
Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone/Chorionic Somatomammotropin genes
Laura Sedman, Badri Padhukasahasram, Piret Kelgo, Maris Laan · 2008 · Human Mutation
Comparison of pulsatile vs. continuous administration of human placental growth hormone in female C57BL/6J mice
Shutan Liao, Mark Hedley Vickers, Angharad Evans, Joanna L. Stanley, Philip Newton Baker, Jo Kate Perry · 2016 · Endocrine
CTRP-1 levels are related to insulin resistance in pregnancy and gestational diabetes mellitus
Carola Deischinger, Karoline Leitner, Sabina M. Baumgartner-Parzer, Dagmar Bancher‐Todesca, Alexandra Kautzky‐Willer, Jürgen Harreiter · 2020 · Scientific Reports
Elevated Maternal Folate Status and Changes in Maternal Prolactin, Placental Lactogen and Placental Growth Hormone Following Folic Acid Food Fortification: Evidence from Two Prospective Pregnancy Cohorts
Tanja Jankovic‐Karasoulos, M. Smith, Shalem Leemaqz, Jessica M. Williamson, Dylan McCullough, Anya L. Arthurs, Lauren A. Jones, K. Justinian Bogias, Ben W. Mol, Julia A. Dalton et al. · 2023 · Nutrients
Adaptability and potential for treatment of placental functions to improve embryonic development and postnatal health
James C. Cross · 2015 · Reproduction Fertility and Development
Effects of diet-induced obesity on protein expression in insulin signaling pathways of skeletal muscle in male Wistar rats
Ebrahim Khalil Naderali, Fatani, Abubakari, Imose Itua, Christopher Wong, Thomas · 2012 · International Journal of General Medicine
Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition
Naoel Hassan Feres, Sílvia Regina de Lima Reis, Roberto Vilela Veloso, Vanessa Cristina Arantes, Letícia Martins Ignácio-Souza, Everardo M. Carneiro, Antonio Carlos Boschero, Marise Auxiliadora de Barros Reis, Márcia Queiroz Latorraca · 2009 · Nutrition
Molecular Mechanisms of Insulin Resistance
Boris Draznin · 2019 · Contemporary Endocrinology
Human Placental Growth Hormone Is Increased in Maternal Serum in Pregnancies Affected by Down Syndrome
Eleftheria Papadopoulou, Stavros Sifakis, Emmanuel Giahnakis, Yvoni G. Fragouli, Nikolaos S. Karkavitsas, Eugenios E. Koumantakis, Maria Kalmanti · 2008 · Fetal Diagnosis and Therapy
Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus
Takanori Hayashi, Tetsuya Kubota, Mariko Inoue, Iseki Takamoto, Masakazu Aihara, Yoshitaka Sakurai, Nobuhiro Wada, Takashi Miki, Toshimasa Yamauchi, Naoto Kubota et al. · 2021 · Diabetes
Pancreatic Neuroendocrine Tumour in Pregnancy - Diagnosis and Treatment Management
Dragos Valentin Predescu · 2019 · Chirurgia
Increased levels of human placental growth hormone in the amniotic fluid of pregnancies affected by Down syndrome
S. Sifakis, E. Papadopoulou, Anastasia Evangelia Konstantinidou, Emmanuel Giahnakis, Yvoni G. Fragouli, N Karkavitsas, E. Koumantakis, Maria Kalmanti · 2008 · Growth Hormone & IGF Research
Fatty-Sucrosed Diet/Minimal Dose of Streptozotocin-Treated Rat: A Novel Model of Gestational Diabetes Mellitus, Metabolic and Inflammatory Insight
2014 · Journal of Diabetes & Metabolism
Endocrine Emergencies During Pregnancy
Odessa Persia Hamidi, Linda A. Barbour · 2022 · Obstetrics and Gynecology Clinics of North America
Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture
Fredrick Joseph Rosario, Sammy Pardo, Trond Melbye Michelsen, Kathryn Erickson, LORNA GRINDLAY MOORE, Theresa L. Powell, Susan T. Weintraub, Thomas Jansson · 2021 · Frontiers in Cell and Developmental Biology
Differential effects of single fatty acids and fatty acid mixtures on the phosphoinositide 3-kinase/Akt/eNOS pathway in endothelial cells
Kim G. Jackson, K. J. Newens, Michael J. Fry, Abby K. Thompson, Christine M. Williams · 2022 · European Journal of Nutrition
Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes
Soumyalekshmi Nair, Valeska Ormazábal, Flavio Carrión, Aase Handberg, David H. McIntyre, Carlos Salomón · 2023 · Clinical Science
Biphasic effects of chronic ethanol exposure on insulin‐stimulated glucose uptake in primary cultured rat skeletal muscle cells: role of the Akt pathway and GLUT4
Wei Qu, Lina Zhao, Xiaolin Peng, Xuefeng Yang, Chenjiang Ying, Liping Hao, Xiufa Sun · 2010 · Diabetes/Metabolism Research and Reviews
Mechanisms Underlying Insulin Resistance in Human Pregnancy and Gestational Diabetes Mellitus
Carrie E. McCurdy, Jacob E. Friedman · 2010 · Springer eBooks
Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
Vitor F. Martins, Shahriar Tahvilian, Ji‐Hoon Kang, Kristoffer Svensson, Byron Hetrick, Wallace S.H. Chick, Simon Schenk, Carrie E. McCurdy · 2018 · Frontiers in Physiology
Early-Pregnancy Serum Maternal and Placenta-Derived Exosomes miRNAs Vary Based on Pancreatic β-Cell Function in GDM
Melissa Razo-Azamar, Rafael Nambo‐Venegas, Iván R. Quevedo, Gregorio Juárez-Luna, Carlos Salomón, Martha Guevara‐Cruz, Berenice Palacios‐González · 2023 · The Journal of Clinical Endocrinology & Metabolism
Maternal Hypothyroidism in Rats Reduces Placental Lactogen, Lowers Insulin Levels, and Causes Glucose Intolerance
Nykola L. Kent, Sharat Chandra Atluri, James S. M. Cuffe · 2021 · Endocrinology
Molecular Basis of Insulin Resistance and Its Relation to Metabolic Syndrome
Sarika Arora · 2012 · InTech eBooks
On Rheostasis
Tyler John Stevenson · 2023
Endocrine Diseases of Pregnancy
Andrea G. Edlow, Errol R. Norwitz · 2019 · Elsevier eBooks
Mechanisms of Fetal Overgrowth in Gestational Diabetes: The Potential Role of SOCS2
Luisa Hernández-Baraza, Yeray Brito‐Casillas, Carmen Valverde‐Tercedor, Carlota Recio, Leandro Fernández‐Pérez, Borja Guerra, Ana María Wägner · 2025 · Nutrients
Desensitization of the JAK2/STAT5 GH signaling pathway associated with increased CIS protein content in liver of pregnant mice
Johanna Gabriela Miquet, Ana I. Sotelo, Andrzej Bartke, Daniel Turyn · 2005 · American Journal of Physiology-Endocrinology and Metabolism
GESTATIONAL DIABETES- A REVIEW
Sivagaminathan Palani, Nisha Mary, Yonatan Tegene, Anish Zacharia, Tesfa Marew · 2014
Reduction of PTP1B induces differential expression of PI3-kinase (p85α) isoforms
Cristina M. Rondinone, Jill E. Clampit, Rebecca J. Gum, Bradley A. Zinker, Michael R. Jirousek, James M. Trevillyan · 2004 · Biochemical and Biophysical Research Communications
Envejecimiento y resistencia a la insulina. Más allá del síndrome metabólico
Carles Zafón · 2007 · Revista Española de Geriatría y Gerontología
Human trophoblast differentiation
Danièle Evain‐Brion, Jean Guibourdenche, Vassili Tsatsaris, Thierry Fournier · 2009 · Bulletin de l Académie Nationale de Médecine
Monitoring motherhood: Monitoring and optimizing glycaemia in women with pre-existing diabetes in pregnancy
Claire L. Meek · 2021 · Annals of Clinical Biochemistry International Journal of Laboratory Medicine
Correction: Maternal and Fetal Placental Growth Hormone and IGF Axis in Type 1 Diabetic Pregnancy
Mary Higgins, Noirin E. Russell, Paul A. Crossey, Kristine C. Nyhan, Derek P. Brazil, Fionnuala Mary McAuliffe · 2012 · PLoS ONE
Modulation of insulin signaling pathway genes by ozone inhalation and the role of glucocorticoids: A multi-tissue analysis
Mercedes Rose, Alain Filiatreault, Andrew Williams, Josée Guénette, Errol M. Thomson · 2023 · Toxicology and Applied Pharmacology
Unmasked insulinoma occasioned by severe hypoglycemic coma immediately postpartum: a case report
Kiyoshi Matsumoto, Miyu Watanabe, Ken Takao, Hirokazu Takahashi, Hisashi Daido, Toshiro Shibata, Tokuyuki Hirose, Takehiro Kato, Masami Mizuno, Takuo Hirota et al. · 2023 · BMC Endocrine Disorders
Relationship Between Maternal Bone Biomarkers and Fetal Adiposity Through Normal Pregnancy
George P. Mastorakos, Dimosthenis Maliopoulos, Spyridoula Kasioni, Αlexandra Bargiota, Thomas M. Barber, Chrysanthi L. Skevaki, Ioannis Papassotiriou, Nikos Vrachnis, George Farmakides, Nikolaos Vlahos et al. · 2021 · The Journal of Clinical Endocrinology & Metabolism
The Metabolic Syndrome in Hispanics – The Role of Insulin Resistance and Inflammation
Pablo I., Jose M., Nelson Escobales, Maria Crespo, Hector L. · 2012 · InTech eBooks
Molecular Mechanisms of Insulin Resistance
Boris Draznin · 2009 · Humana Press eBooks
A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie Restriction
Isao Shimokawa · 2006 · Elsevier eBooks
Is It Worth Assessing the Prevalence of Sarcopenia in Pregnant Women? Should Any Impact on Pregnancy Outcomes Be Expected?
Christian S. Göbl, Angela Dardano, Giuseppe Daniele, Andrea Tura · 2025 · Nutrients
Subclinical inflammation as a factor for the development of insulin resistance during pregnancy
Roman Viktorovich Kapustin, Ol’ga Nikolaevna Arzhanova · 2017 · Russian Bulletin of Obstetrician-Gynecologist
[Clinical experience in 37 cases of insulinoma].
Adriana Graciela Díaz, Sabrina Paola Lucas, Pedro A. Ferraina, Ariel Ferraro, Félix Puchulu, Andrea Páes de Lima, María del Carmen Maselli, Reynaldo Manuel Gomez, Oscar Domingo Bruno · 2006 · PubMed
Biochemical Events in Basophil/Mast Cell Activation and Mediator Release
Donald W. MacGlashan · 2009 · Elsevier eBooks
Molecular investigation of genetic factors associated with insulin resistance and obesity in a South African population
Zelda Vergotine · 2015 · SUNScholar (Stellenbosch University)
Assembly of novel, nuclear dimers of the PI3-Kinase regulatory subunits underpins the pro-proliferative activity of the Cdc42-activated tyrosine kinase, ACK
Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia, Courtney M. Schroeder, Trevor D. Littlewood, Jonathan I. Wilde, Jessica Corry, Kadalmani Krishnan, Qifeng Zhang, Michael J.O. Wakelam et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Assessment of Changes in the Expression of Genes Involved in Insulin Signaling and Glucose Transport in Leukocytes of Women with Gestational Diabetes During Pregnancy and in the Postpartum Period
Andrzej Zieleniak, Monika Żurawska-Kliś, Karolina Laszcz, Krystsina Bulash, Dagmara Pacyga, Katarzyna Cypryk, Lucyna A. Woźniak, Marzena Wójcik · 2024 · International Journal of Molecular Sciences
Gestational diabetes: Potential of prebiotics intervention
Li Shen, Michael J. Keenan, Jun F. Zhou, Roy Joseph Martin · 2016 · Civil War Book Review
The Potential Impact of Maternal Milk Consumption During Pregnancy on mTORC1-Driven Fetal Growth
Bodo Clemens Melnik · 2016 · Springer eBooks
Gestational Glucose Metabolism: Focus on the Role and Mechanisms of Insulin Resistance
Md. Wasim Khan, Brian Thomas Layden · 2019 · Elsevier eBooks
Gestational Diabetes: From Mechanism to Therapy – A Short Review
Raluca Cursaru, Angelica Bratu, Gabriela Radulian, Mirela Luminița Pavelescu, Emilia Rusu, Florin C. Cirstoiu, Adrian Cursaru · 2024 · Romanian Journal of Military Medicine
Maternal Growth Hormone/Insulin-like Growth Factor Axis and Placental Growth Hormone in Pregnancies Complicated by Diabetes and Thyroid Disease: A Systematic Review Integrating Mechanistic Evidence
Wiku Andonotopo, Mochammad Besari Adi Pramono, Julian Dewantiningrum, Wisnu Prabowo, Muhammad Adrianes Bachnas, I Nyoman Hariyasa Sanjaya, Anak Agung Gede Putra Wiradnyana, Anak Agung Ngurah Jaya Kusuma, Khanisyah Erza Gumilar, Ernawati Darmawan et al. · 2025 · Journal of Advanced Trends in Medical Research
Adaptations métaboliques au cours de la grossesse
Cécile Jacovetti, Romano Regazzi · 2012 · Médecine des Maladies Métaboliques
Some Aspects of Endocrinology of the Placenta
Lawrence D. Longo · 2018 · Springer eBooks
Wakouba an Antidiabetic Plant Extract with Protective Effect against Cardiovascular and Nephropathies Complications in Streptozotocin-Induced Diabetic Rats
Francis Kouame · 2018 · Medical Journal of Clinical Trials & Case Studies
Endocrine Diseases of Pregnancy
Andrea G. Edlow, Errol R. Norwitz · 2013 · Elsevier eBooks
Hierarchical organization of physiological stability
Tyler John Stevenson · 2023 · Oxford University Press eBooks
Pregnancy and metabolic syndrome of obesity
Sarah Barr, Scott McGill Nelson, Shahzya S. Huda · 2020 · Elsevier eBooks
Pathophysiology of Diabetes in Pregnancy
Francine Hughes Einstein · 2010 · Wiley eBooks
Metabolic alterations induced by high maternal BMI and gestational diabetes in maternal, placental and neonatal outcomes
Jole Martino · 2013 · Nottingham ePrints (University of Nottingham)
C-terminal truncation of Pik3r1 in mice models human lipodystrophic insulin resistance uncoupled from dyslipidemia
Albert Kwok, I. Zvetkova, S. Virtue, I. Huang-Doran, P. Tomlinson, David A. Bulger, Daniel Hart, R. Knox, S. Franks, P. Voshol et al. · 2017 · bioRxiv
La régulation du métabolisme du glucose par la protéine tyrosine phosphatase SHP-1
Sébastien Bergeron · 2007 · Corpus Université Laval (Université Laval)
Association of prenatal depression and plasma prolactin concentrations with neonatal birthweight
Shan Wang, Xiaowen Jia, Dan Zhang, Shengquan Chen, Meina Xu, Xi Jin, Zhongliang Zhu, Hui Li · 2022 · Research Square
Glossary
Tyler John Stevenson · 2023 · Oxford University Press eBooks
Estudo das vias intracelulares de sinalização da insulina e da angiotensina-II no hipotálamo de ratas grávidas e lactantes.
Jorge Vinícius Cestari Félix · 2012 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
Methodological and Clinical Studies on Insulin Resistance in Childhood
Sophia M Rössner · 2011 · Figshare
MATERNAL OBESITY AND OXIDATIVE STRESS IN THE FETUS: MECHANISMS UNDERLYING EARLY LIFE SHIFTS IN SKELETAL MUSCLE METABOLISM
Kristen E. Boyle, Jacob E. Friedman · 2011 · Fetal and Maternal Medicine Review
Physiological acromegaly of pregnancy
Johan Verhaeghe · 2008 · Expert Review of Endocrinology & Metabolism
SYNDICAT SUD SANTE SOCIAUX 35
Sud Santé Sociaux · 2019
Epidemiology, aetiology and pathogenesis of diabetes in pregnancy
Anne Dornhorst, Shivani Misra · 2015 · Wiley eBooks
Critical Importance of the Perinatal Period in the Development of Obesity
Peter Russell Baker, Jacob E. Friedman · 2014 · Springer eBooks
Effects of Growth Hormone, IGF-1, or Combination Therapy on Muscle Fiber Type Composition in Diabetic Mice
Sean Schumm · 2011 · OhioLink ETD Center (Ohio Library and Information Network)
Tissue specificity of 17?-estradiol effects on insuli signaling pathway
Tijana Milosavljević · 2012
Mathematical Modeling of the PI3K-AKT-TOR Pathway
PhD, Guanyu Wang · 2013 · CRC Press eBooks
Le placenta: une glande endocrine transitoire Conséquences sur la fonction antéhypophysaire au cours de la grossesse
Danièle Evain‐Brion · 2007 · Springer eBooks
Metabolic and Endocrine Responses to Overeating.
Andrea S. Cornford · 2012 · Deep Blue (University of Michigan)
Early life programming of cardiometabolic disease: the role of prenatal zinc, intrauterine growth, and the development of the fetal autonomic nervous system
Monica L. Mispireta · 2015
Metabolic study of Alzheimer’s disease using mutant C. elegans
Waqar Ahmad · 2017 · The University of Queensland
The 20-kDa Placental GH Variant: A New and Improved Growth Hormone?
Mark Hedley Vickers, Jo Kate Perry · 2020 · Endocrinology
Treating the Placenta with a Nanoparticle-Encapsulated Mitochondrial Antioxidant Improves Placental Function and Fetal Cardiomyocyte Development in a Rat Model of Prenatal Hypoxia
Esha Ganguly · 2021 · ERA: Education and Research Archive (University of Alberta)
Placenta et croissance fœtale
Danièle Evain‐Brion · 2012 · Springer eBooks
Faculty Opinions recommendation of The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation.
Ana Claudia Zenclussen · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Pathophysiology of Diabetes in Pregnancy
Francine Hughes Einstein · 2017 · Wiley eBooks
Faculty Opinions recommendation of Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling.
Karen E. Chapman · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
A. Optimization of Insulin Action
PhD, Guanyu Wang · 2013 · CRC Press eBooks
Dietary resistant starch improved maternal glycemic control in Goto-Kakizaki rat
Shen, Li · 2010 · Louisiana State University
Efeitos de citocinas e fatores de crescimento sobre neurônios hipotalâmicos: estudo do fator de necrose tumoral-, interleucina-6, interleucina IL-1, hormônio do crescimento e fator de crescimento semelhante à insulina.
Fernanda M. Chaves · 2021
Molecular Basis of Role of Insulin Resistance in Pathophysiology of Alzheimer’s Disease
Anil Gupta · 2022 · International Journal of Health Sciences and Pharmacy
Effects of short-term growth hormone administration on plasma leptin levels in normal and diet-induced obesity rats
Sutharinee Likitnukul · 2017 · Chula Digiverse
Orchestration of female reproductive cycles
Tyler John Stevenson · 2023 · Oxford University Press eBooks
A seasonally programmed energy rheostat
Tyler John Stevenson · 2023 · Oxford University Press eBooks
Programmed and reactive rheostasis
Tyler John Stevenson · 2023 · Oxford University Press eBooks
The reactive response of life
Tyler John Stevenson · 2023 · Oxford University Press eBooks
An endogenous clock for programmed rheostasis
Tyler John Stevenson · 2023 · Oxford University Press eBooks