Vasopressin autoreceptors and nitric oxide-dependent glutamate release are required for somatodendritic vasopressin release from rat magnocellular neuroendocrine cells responding to osmotic stimuli
Abstract
Magnocellular neuroendocrine cells of the supraoptic nucleus (SON) release vasopressin (VP) systemically and locally during osmotic challenge. Although both central VP and nitric oxide (NO) release appear to reduce osmotically stimulated systemic VP release, it is unknown whether they interact locally in the SON to enhance somatodendritic release of VP, a phenomenon believed to regulate systemic VP release. In this study, we examined the contribution of VP receptor subtypes and NO to local VP release from the rat SON elicited by systemic injection of 3.5 m saline. Treatment of SON punches with VP receptor antagonists decreased osmotically stimulated intranuclear VP release. Similarly, blockade of NO production, or addition of NO scavengers, reduced stimulated VP, glutamate, and aspartate release, suggesting that local NO production and activity are critical for osmotically induced intranuclear VP and excitatory amino acid release. An increase in endogenous NO release from SON punches in response to hyperosmolality was confirmed by enzymatic NO assay. Consistent with enhanced glutamate and VP release from stimulated rat SON punches, the ionotropic glutamate receptor blocker kynurenate decreased stimulated local VP release without affecting NO release. These data suggest that NO enhances local VP release in part by facilitating local release of glutamate/aspartate and that glutamate receptor activity is required for the stimulation of local VP release by osmotic challenge. Coll…
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These AVP neurons receive osmosensitive inputs from the organum vasculosum lamina terminalis via glutamatergic synapses and are modulated by nitric oxide (NO) signaling pathways.
“These AVP neurons receive osmosensitive inputs from the organum vasculosum lamina terminalis via glutamatergic synapses and are modulated by nitric oxide (NO) signaling pathways (146–148).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [148]
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Johnson, Z. V., & Young, L. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242 · see citing works
Endocrine Disruption of Vasopressin Systems and Related Behaviors
Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54 · see citing works
Coburn, C. G., Curras-Collazo, M. C., & Kodavanti, P. R. S. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm086 · Cited by 45 · see citing works
Self-citationYi, S. S., Hwang, I. K., Kim, Y. N., Kim, I. Y., Pak, S.-I., Lee, I. S., Seong, J. K., & Yoon, Y. S. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9519-2 · Cited by 30 · see citing works
Shah, A., Coburn, C. G., Watson-Siriboe, A., Whitley, R., Shahidzadeh, A., Gillard, E. R., Nichol, R., Leon-Olea, M., Gaertner, M., Kodavanti, P. R. S., et al. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.014 · Cited by 24 · see citing works
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- Authors
- Gillard, E. R., Coburn, C. G., de Leon, A., Snissarenko, E. P., Bauce, L. G., Pittman, Q. J., Hou, B., & Currás-Collazo, M. C.
- Affiliations
- University of California, Riverside (US)
- University of Calgary (CA)
- Corresponding author
- Gillard, E. R.
- ORCID
- Pittman, Q. J.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-02
- Volume
- 148
- Issue
- 2
- Pages
- 479-489
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2006244847
- Cited by
- 34
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2015: 3 · 2014: 4 · 2013: 2
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- vasopressin, nitric oxide, glutamate release, aspartate release, supraoptic nucleus, osmotic stimulation, hyperosmolarity, kynurenic acid, glutamate receptors, osmoregulation
- MeSH terms
- Amino Acids, Animals, Neurosecretory Systems, Nitric Oxide, Osmosis, Sodium Chloride, Supraoptic Nucleus, Vasopressins, Water-Electrolyte Balance, Signal Transduction, Rats, Sprague-Dawley, Receptors, Vasopressin, Autoreceptors, Glutamic Acid, Excitatory Amino Acids, Protein Isoforms, Rats, In Vitro Techniques
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