Differential Activation of the Sympathetic Innervation of Adipose Tissues by Melanocortin Receptor Stimulation

Brito, Márcia N.; Brito, Nilton A.; Baro, Deborah J.; Song, C. Kay; Bartness, Timothy J.

doi:10.1210/en.2007-0621

Differential Activation of the Sympathetic Innervation of Adipose Tissues by Melanocortin Receptor Stimulation

Melanocortins are implicated in the control of energy intake/expenditure. Centrally administered melanotan II (MTII), a synthetic melanocortin 3/4-receptor agonist, decreases adiposity beyond that accountable by food intake decreases. Melanocortin-4 receptor (MC4-R) mRNA is expressed on sympathet…