Discovery of a Functional Glucocorticoid Receptor β-Isoform in Zebrafish

Schaaf, Marcel J. M.; Champagne, Danielle; van Laanen, Ivo H. C.; van Wijk, Diane C. W. A.; Meijer, Annemarie H.; Meijer, Onno C.; Spaink, Herman P.; Richardson, Michael K.

doi:10.1210/en.2007-1364

Discovery of a Functional Glucocorticoid Receptor β-Isoform in Zebrafish

In humans, two glucocorticoid receptor (GR) splice variants exist: GRα and GRβ, which are identical between amino acids 1–727 and then diverge. Whereas GRα (the canonical GR) acts as a ligand-activated transcription factor, GRβ does not bind traditional glucocorticoid agonists, lacks GRα’s transa…