Cited by 273Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

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An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo

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Keen, Kim L., Wegner, Frederick H., Bloom, Stephen R., Ghatei, Mohammad A., Terasawa, Ei·2008·Endocrinology

DOI 10.1210/en.2008-0231PMC PMC2488227

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Abstract

The G-protein coupled receptor GPR54 and its ligand, KiSS-1-derived peptide kisspeptin-54, appear to play an important role in the mechanism of puberty. This study measures the release of kisspeptin-54 in the stalk-median eminence (S-ME) during puberty and examines its potential role in the pubertal increase in LHRH-1 release in female rhesus monkeys. First, developmental changes in release of kisspeptin-54 and LHRH-1 were assessed in push-pull perfusate samples obtained from the S-ME of prepubertal, early pubertal, and midpubertal female rhesus monkeys. Whereas LHRH-1 levels in 10-min intervals had been measured previously for other experiments, kisspeptin-54 levels in 40-min pooled samples were newly measured by RIA. The results indicate that a significant increase in kisspeptin-54 release occurred in association with the pubertal increase in LHRH-1 release and that a nocturnal increase in kisspeptin-54 release was already observed in prepubertal monkeys and continued through the pubertal period. Second, we measured kisspeptin-54 release in the S-ME of midpubertal monkeys at 10-min intervals using a microdialysis method. Kisspeptin-54 release in the S-ME was clearly pulsatile with an interpulse interval of about 60 min, and approximately 75% of kisspeptin-54 pulses were correlated with LHRH-1 pulses. Finally, the effect of kisspeptin-10 on LHRH-1 release was examined with the microdialysis method. Kisspeptin-10 infusion through a microdialysis probe significantly stimulated LHRH-1 release in a dose-dependent manner. Collectively, the results are consistent with the hypothesis that kisspeptin plays a role in puberty.

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Authors: Keen, K. L., Wegner, F. H., Bloom, S. R., Ghatei, M. A., & Terasawa, E.
Affiliations: University of Wisconsin–Madison (US)
Imperial College London (GB)
Corresponding author: Terasawa, Ei
ORCID: Bloom, Stephen R.
Terasawa, Ei
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2008-05-01
Volume: 149
Issue: 8
Pages: 4151-4157
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2008-0231
PMC: PMC2488227
OpenAlex: W2019501332
Cited by: 273
References: 41
Citations by year: 2026: 2 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 14 · 2021: 16 · 2020: 11 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 15 · 2015: 15 · 2014: 29 · 2013: 29 · 2012: 34
FWCI: 21.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research (NF-SI-0507-10337)
Biotechnology and Biological Sciences Research Council (BB/E52708X/1)
National Center for Research Resources (RR020141, C06RR020141, RR15459, C06RR015459, P51RR000167)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01-HD-11355, R01HD015433, R01 HD15433, R01HD011355)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: kisspeptin-54, kisspeptin-10, gonadotropin-releasing hormone, puberty, stalk-median eminence, GPR54, pulsatile hormone secretion, rhesus monkeys, female reproduction
MeSH terms: Animals, Dose-Response Relationship, Drug, Female, Gonadotropin-Releasing Hormone, Macaca mulatta, Median Eminence, Oligopeptides, Pulsatile Flow, Sexual Maturation, Time Factors, Microdialysis, Tumor Suppressor Proteins, Kisspeptins

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An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo

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