Regulation of NKB Pathways and Their Roles in the Control of Kiss1 Neurons in the Arcuate Nucleus of the Male Mouse

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse

Gottsch, M. L., Cunningham, M. J., Smith, J. T., Popa, S. M., Acohido, B. V., Crowley, W. F., Seminara, S., Clifton, D. K., & Steiner, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0431 · Cited by 1,161

Regulation of Kiss1 gene expression in the brain of the female mouse

Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction

Topaloglu, A. K., Reimann, F., Guclu, M., Yalin, A. S., Kotan, L. D., Porter, K. M., Serin, A., Mungan, N. O., Cook, J. R., Ozbek, M. N., et al. (2009) · Nature Genetics · doi:10.1038/ng.306 · Cited by 961

Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2004) · Neuroendocrinology · doi:10.1159/000083140 · Cited by 930

Kisspeptin Signaling in the Brain

Oakley, A. E., Clifton, D. K., & Steiner, R. A. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0005 · Cited by 842

Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse

Navarro, V. M., Gottsch, M. L., Chavkin, C., Okamura, H., Clifton, D. K., & Steiner, R. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-09.2009 · Cited by 779

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

Lehman, M. N., Coolen, L. M., & Goodman, R. L. (2010) · Endocrinology · doi:10.1210/en.2010-0022 · Cited by 768

Differential Regulation of KiSS-1 mRNA Expression by Sex Steroids in the Brain of the Male Mouse

Smith, J. T., Lemko, H. M. D., Stoll, E. A., Gottsch, M. L., Braun, R. E., Eacker, S. M., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0323 · Cited by 717

Kisspeptin and neurokinin B expression in the human hypothalamus: Relation to reproduction and gender identity

Bakker, J. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00018-5 · Cited by 5

Male Reproductive Endocrinology

Tsametis, C. P., Kanakis, G., & Goulis, D. G. (2023) · Cambridge University Press eBooks · doi:10.1017/9781009197533.006 · Cited by 5

Tacking Toward Reconciliation on Tacr3/TACR3 Mutations

Steiner, R. A., & Navarro, V. M. (2012) · Endocrinology · doi:10.1210/en.2012-1032 · Cited by 4

Endogeneous Signals and Mammalian Puberty Onset: A Review

Nabi, G., Amin, M., Khan, A., & Kamil, M. K. M. (2014) · Journal of Biology and Life Science · doi:10.5296/jbls.v6i1.6032 · Cited by 6

The Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs

Liu, P. Y., & Veldhuis, J. D. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00013-5 · Cited by 4

Activation of Kiss1 neurons in the preoptic hypothalamus stimulates testosterone synthesis in adult male micePreprint

Sanz, E., Bean, J. C., Palmiter, R. D., Quintana, A., & McKnight, G. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.03.410878 · Cited by 4

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductancesPreprint

Qiu, J., Voliotis, M., Bosch, M. A., Li, X. F., Zweifel, L. S., Tsaneva-Atanasova, K. T., O'Byrne, K. T., Rønnekleiv, O. K., & Kelly, M. J. (2024) · eLife · doi:10.7554/elife.96691 · Cited by 4

Unraveling Hypothalamus‐Pituitary dysregulation: Hypergonadotropism in F1 progeny due to prenatal exposure to hexavalent chromium

Navin, A. K., Aruldhas, M. M., Mani, K. K., Navaneethabalakrishnan, S., Venkatachalam, S., & Banu, S. K. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23699 · Cited by 3

Gene Networks, Epigenetics and the Control of Female Puberty

Lomniczi, A., Castellano, J. M., Wright, H., Selcuk, B., Sönmez, K., & Ojeda, S. R. (2014) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-09168-6_8 · Cited by 3

Maturation of the Hypothalamic-Pituitary-Ovarian Axis and the Onset of Puberty

Paris, F., Gaspari, L., & Sultan, C. (2017) · ISGE series · doi:10.1007/978-3-319-41433-1_6 · Cited by 3

The Effects of the Novel Reproductive Peptide Phoenixin-20 Amide on GnRH and Kisspeptin Hypothalamic Cell Models

Treen, A. K. (2014) · TSpace (University of Toronto) · Cited by 3

KNDy Neurons and the Control of the Gonadotropic Axis in the Midgestation Fetal Sheep

Amodei, R., Jonker, S. S., Lazen, E., Nestor, C. C., Estill, C. T., & Roselli, C. E. (2025) · Endocrinology · doi:10.1210/endocr/bqaf049 · Cited by 2

Polycystic ovary syndrome: Unveiling the multifaceted contributors, mechanisms, and psychological impacts

Bhati, P., Haloi, P., Munjal, K., & Chitme, H. R. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105844 · Cited by 2

Absence of sex differences in diabetes-induced suppression of KNDy neurons in rats

Otsuka, M., Iwata, K., Otsuka, Y., Uenoyama, Y., Ozawa, H., & Ishii, H. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0293 · Cited by 2

Unraveling the Neural Mechanisms Underlying the GnRH Pulse Generator: An Update

Goodman, R. L., Coolen, L. M., & Lehman, M. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00019-3 · Cited by 2

Hypothalamic Regulation of Anterior Pituitary Function

Ben-Shlomo, A., & Melmed, S. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99899-4.00021-4 · Cited by 2

Epigenetic and Transcriptional Regulation of the Reproductive Hypothalamus

Aylwin, C. F., & Lomniczi, A. (2020) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-40002-6_8 · Cited by 1

Role of membrane estrogen receptor alpha on the negative feedback of estrogens on luteinizing hormone secretion

Faure, M., Corona, R., Vandries, L. M., Deconinck, C., Lenfant, F., Gérard, C., Foidart, J., & Cornil, C. A. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70016 · Cited by 1

A synaptoid connectome differentiates tanycytic subpopulations and underlies neuroglial communication and neuroendocrine regulation

Neve, V., Fernandois, D., Rai, S., Özorhan, Ü., Nampoothiri, S. S., Ternier, G., Sideromenos, S., Gallet, S., Allet, C., Stahr, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74598-5 · Cited by 1

Control of the GnRH Pulse Generator

Tena‐Sempere, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408134-5.00019-6 · Cited by 1

Morphology and distribution of hypothalamic peptidergic systems.

Dudás, B., & Merchenthaler, I. (2021) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-819975-6.00002-9 · Cited by 1

Neuroanatomy of the GnRH/Kisspeptin System

Spergel, D. J. (2021) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-86630-3_8 · Cited by 1

Interactions of GPR54 and GPR147 receptors with RF-amide ligands

Hendrikse, M. (2014) · Open University of Cape Town (University of Cape Town) · Cited by 1

Investigating and characterizing phoenixin and tachykinin receptor-3 in the reproductive axis of the chicken, Gallus gallus

Sparling, B. A. T. E. (2017) · The Atrium (University of Guelph) · Cited by 1

The Role of KNDy Neurons and Neuronal Nitric Oxide Synthase in the Control of Reproduction in Female Sheep and Nonhuman Primates

Bedenbaugh, M. N. (2018) · doi:10.33915/etd.5174 · Cited by 1

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductancesPreprint

Qiu, J., Voliotis, M., Bosch, M. A., Li, X. F., Zweifel, L. S., Tsaneva-Atanasova, K. T., O’Byrne, K. T., Rønnekleiv, O. K., & Kelly, M. J. (2024) · eLife · doi:10.7554/elife.96691.1 · Cited by 1

Effects of Prenatal Testosterone on the Reproductive and Metabolic Neurons of the Sheep Hypothalamus

Cernea, M. (2013) · Scholarship@Western (Western University)

Neuropeptide signalling systems involved in the timing of puberty onset and regulation of the gonadotrophin-releasing hormone pulse generator in the rat

Li, S. (2016) · Research Portal (King's College London)

Neuropeptide and Gonadal Steroid Action on Arcuate Kisspeptin Neurons: Implications for Central Regulation of Fertility.

Ruka, K. A. (2015) · Deep Blue (University of Michigan)

Metabolic Responsiveness of a Novel GnRH-GFP Neuronal Cell Model

McFadden, S. A. (2010) · TSpace (University of Toronto)

Regulation of Kisspeptin-expressing Neurons and Stimulatory Mode of Action of Kisspeptin in Immortalized Hypothalamic Cell Models

Friedman, Z. (2013) · TSpace (University of Toronto)

Efeito da dieta hiperlipídica sobre a responsividade de neurônios kisspeptidérgicos à leptina

Venancio-Brochi, J. C. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2016.tde-06012016-164539

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruíz-Pino, F., Roa, J., Beiroa, D., Heras, V., Velasco, I., Diéguez, C., Pinilla, L., et al. (2019) · Yearbook of pediatric endocrinology · doi:10.1530/ey.16.7.2

Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ

Nestor, C. C. (2012) · doi:10.33915/etd.4903

Identification of hypothalamic sites that control puberty onset and sexual maturation

Greenwald-Yarnell, M. L. (2013) · Deep Blue (University of Michigan)

Faculty Opinions recommendation of Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron.

Colmers, W. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.739392019.793583568

Faculty Opinions recommendation of Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications.

Bellastella, A. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.14267154.15779314

Faculty Opinions recommendation of High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons.

Plant, T. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726666771.793561658

Pubertätsentwicklung und Adipositas

Stein, R., Sergeyev, E., Göpel, E., Stoltze, A., Gesing, J. K., Pfäffle, R. W., Körner, A., & Kieß, W. (2023) · Kinder- und Jugendmedizin · doi:10.1055/a-1971-8578

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductancesPreprint

Qiu, J., Voliotis, M., Bosch, M. A., Li, X. F., Zweifel, L. S., Tsaneva-Atanasova, K. T., O’Byrne, K. T., Rønnekleiv, O. K., & Kelly, M. J. (2024) · eLife · doi:10.7554/elife.96691.2

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductancesPreprint

Qiu, J., Voliotis, M., Bosch, M. A., Li, X. F., Zweifel, L. S., Tsaneva-Atanasova, K. T., O’Byrne, K. T., Rønnekleiv, O. K., & Kelly, M. J. (2024) · eLife · doi:10.7554/elife.96691.3

Anatomy and Physiology of the Male Reproductive System and Potential Targets of Toxicants

Ing, N. H., Curley, K. O., Welsh, T. H., Johnson, L. W., Luense, L. J., Clement, T. M., & Staub, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00208-4

Acute Endotoxemia Inhibits Luteinizing Hormone Secretion and Decreases Hypothalamic Kisspeptin Expression in Adult CowsPreprint

Renwick, A. N., Whitlock, B. K., Nestor, C. C., Esteller‐Vico, A., Amelse, L. L., & Sanchez, N. C. B. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5102310

Kisspeptin-Dependent Puberty Onset Triggered by Increased Kiss1 and Pdyn Expression in Arcuate Tac3 Neurons under Reduced Estrogen Negative Feedback and Sufficient Energy Balance in Female Rats

Nagae, M., Majarune, S., Kobayashi, T., Nima, P., Horihata, K., Takase, K., Hirata, J., Matsui, H., Matsumoto, H., Inoue, N., et al. (2025) · Neuroendocrinology · doi:10.1159/000548403

Fezolinetant: the first FDA-approved neurokinin-3 receptor antagonist for treating moderate-to-severe vasomotor symptoms associated with menopause

Han, B. R., Wang, M., Chen, Q., & Zhang, Q. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33885-4.00031-7

Inhibitory effects of a κ-opioid receptor agonist and neurokinin-3 receptor antagonist on testosterone secretion in male rats

Sakono, T., Munetomo, A., Sato, M., ISHIYAMA, D., Oshimo, Y., Yamamoto, K., Oishi, S., Magata, F., & Matsuda, F. (2025) · Theriogenology · doi:10.1016/j.theriogenology.2025.117780

Citalopram-induced decrease of CLOCK-ir and BMAL1-ir kisspeptin neurons in the anteroventral periventricular nucleus of adult male mice

Putteeraj, M., Soga, T., & Parhar, I. S. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.09.014

Ontogenèse des neurones à kisspeptine chez le rat : neurogénèse et cartographie spatio-temporelle de kisspeptine de l'embryogénèse à l'âge adulte

Crossard, E. (2011) · theses.fr (ABES) · doi:10.70675/5288a1dazbccfz4adbz8a03z5c3278f0389b

Contribution à la caractérisation de nouveaux gènes impliqués dans les hypogonadismes hypogonadotropes : caractérisation des mécanismes moléculaires et cellulaires

Francou, B. (2016) · theses.fr (ABES) · doi:10.70675/d1a18abcz32e5z48f9z9502z93a674ff6c83

Mise en place prénatale des cellules à kisspeptine du noyau arqué chez la souris : effet du sexe et de l'oestradiol

Alfaïa, C. (2017) · doi:10.70675/9e1195ccz33c5z47cdza5f6z2eda4790d875

Characterization of tachykinin system and role in reproduction in the European eel

Campo, A. (2018) · theses.fr (ABES) · doi:10.70675/d6441c0cz240dz4d84zbcacz1aa6e622f56b

Divergent effects of hyperandrogenemia on the female reproductive neuroendocrine axis under different physiological conditions

Rose, L., & Kauffman, A. S. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70267

Temporal expression profiles of tachykinin genes throughout the first reproductive cycle, male pregnancy, and brood pouch development in the big-belly seahorse (Hippocampus abdominalis)

Li, J., Ji, F., Li, Y., Zhao, L., Xu, G., Wang, B., & Chen, J. (2026) · Fish Physiology and Biochemistry · doi:10.1007/s10695-026-01809-7

The developmental, genetic, and epigenetic basis of polyendocrine metabolic ovarian syndrome

Mahdi, A., Qannan, A., & Hajj, N. E. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1924187

Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse

Navarro, V. M., Gottsch, M. L., Chavkin, C., Okamura, H., Clifton, D. K., & Steiner, R. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-09.2009 · Cited by 779

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat

Navarro, V. M., Castellano, J. M., McConkey, S. M., Pineda, R., Ruíz-Pino, F., Pinilla, L., Clifton, D. K., Tena‐Sempere, M., & Steiner, R. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00517.2010 · Cited by 251

Investigation of the kisspeptin/neurokinin B/dynorphin (KNDy) neurons by using N-7 cells: immortalized hypothalamic cell line

Osuka, S., Iwase, A., Nakahara, T., Kondo, M., Goto, M., & Kikkawa, F. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.953

Regulation of Arcuate Neurons Coexpressing Kisspeptin, Neurokinin B, and Dynorphin by Modulators of Neurokinin 3 and κ-Opioid Receptors in Adult Male Mice

Ruka, K. A., Burger, L. L., & Moenter, S. M. (2013) · Endocrinology · doi:10.1210/en.2013-1268 · Cited by 150

Neuropeptide and Gonadal Steroid Action on Arcuate Kisspeptin Neurons: Implications for Central Regulation of Fertility.

Ruka, K. A. (2015) · Deep Blue (University of Michigan)