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Cited by 51Neonatal Respiratory Health ResearchCongenital Diaphragmatic Hernia StudiesBirth, Development, and Health

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Pulmonary GLP-1 Receptor Increases at Birth and Exogenous GLP-1 Receptor Agonists Augmented Surfactant-Protein Levels in Litters From Normal and Nitrofen-Treated Pregnant Rats

Romaní-Pérez, Marina, Outeiriño-Iglesias, Verónica, Gil-Lozano, Manuel, González-Matías, Lucas C., Mallo, Federico, Vigo, Eva·2013·Endocrinology
DOI 10.1210/en.2012-1786
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Abstract

The glucagon-like peptide-1 receptor (GLP-1R) is found in a variety of tissues outside of the pancreas. For example, GLP-1R is expressed in the lung, where it has been implicated in the regulation of the lipid fraction of surfactants, suggesting it fulfills an important role in lung function. Here, we show that GLP-1R expression is strongly up-regulated immediately after birth in neonatal rats, particular in male offspring. Moreover, administering long half-life GLP-1R agonists to the mother from gestational day 14 to birth (exendin-4 or liraglutide) increased surfactant protein (SP)-A and SP-B mRNA expression and the amount of SPs in the amniotic fluid at the end of pregnancy. These effects were similar or more potent to those induced by the glucocorticoid dexamethasone, which also increased GLP-1R expression in fetuses just before delivery. Lir increased fetal SP-A and GLP-1R expression in control rats and in a nitrofen-induced model of lung hypoplasia. Moreover, lung size increased in controls after Lir administration, which also prevented the decrease in lung weight and the poor neonatal survival of the offspring from nitrofen-treated dams, effects that were not produced by dexamethasone. Taken together, our results demonstrate the importance of the GLP-1 system in regulating SP production and lung development.

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  1. Mojsov, 1987, Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas, J Clin Invest, 79, 616, 10.1172/JCI112855 · DOI
  2. Kreymann, 1987, Glucagon-like peptide-1 7–36: a physiological incretin in man, Lancet, 2, 1300, 10.1016/S0140-6736(87)91194-9 · DOI · Paper page
  3. Drucker, 1987, Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line, Proc Natl Acad USA, 84, 3434, 10.1073/pnas.84.10.3434 · DOI · Paper page
  4. Navarro, 1996, Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake, J Neurochem, 67, 1982, 10.1046/j.1471-4159.1996.67051982.x · DOI
  5. Näslund, 1998, Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men, Am J Clin Nutr, 68, 525, 10.1093/ajcn/68.3.525 · DOI
  6. Sancho, 2006, Effect of GLP-1 on D-glucose transport, lipolysis and lipogenesis in adipocytes of obese subjects, Int J Mol Med, 17, 1133
  7. Gil-Lozano, 2010, GLP-1(7-36)-amide and exendin-4 stimulate the HPA axis in rodents and humans, Endocrinology, 151, 2629, 10.1210/en.2009-0915 · DOI
  8. Campos, 1994, Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse, Endocrinology, 134, 2156, 10.1210/endo.134.5.8156917 · DOI
  9. Bullock, 1996, Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor, Endocrinology, 137, 2968, 10.1210/endo.137.7.8770921 · DOI
  10. Richter, 1993, GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery, Am J Physiol, 265, L374
  11. Wei, 1996, Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications of their role in human physiology, J Neuroendocrinol, 8, 811, 10.1046/j.1365-2826.1996.05191.x · DOI
  12. Benito, 1998, Glucagon-like peptide-1-(7-36)amide increases pulmonary surfactant secretion through a cyclic adenosine 3′,5′-monophosphate-dependent protein kinase mechanism in rat type II pneumocytes, Endocrinology, 139, 2363, 10.1210/endo.139.5.5998 · DOI
  13. Vara, 2001, Glucagon-like peptide-1(7-36) amide stimulates surfactant secretion in human type II pneumocytes, Am J Respir Crit Care Med, 163, 840, 10.1164/ajrccm.163.4.9912132 · DOI
  14. King, 1985, Lipids synthesis and surfactant turnover in the lungs, 309
  15. King, 1973, Isolation of apoproteins from canine surface active material, Am J Physiol, 224, 788, 10.1152/ajplegacy.1973.224.4.788 · DOI
  16. Dobbs, 1989, Pulmonary surfactant, Annu Rev Med, 40, 431, 10.1146/annurev.me.40.020189.002243 · DOI
  17. Pattle, 1955, Properties, function and origin of the alveolar lining layer, Nature, 175, 1125, 10.1038/1751125b0 · DOI
  18. Clements, 1957, Surface tension of lung extracts, Proc Soc Exp Biol Med, 95, 170, 10.3181/00379727-95-23156 · DOI
  19. Pinkerton, 2000, The mammalian respiratory system and critical windows of exposure for children's health, Environ Health Perspect, 108, 457
  20. Hawgood, 1991, Structures and properties of the surfactant-associated proteins, Annu Rev Physiol, 53, 375, 10.1146/annurev.ph.53.030191.002111 · DOI
  21. Whitsett, 1985, Glycosylation and secretion of surfactant-associated glycoprotein A, J Biol Chem, 260, 15273, 10.1016/S0021-9258(18)95731-5 · DOI
  22. McCormack, 1998, Structure, processing and properties of surfactant protein A, Biochem Biophys Acta, 1408, 109
  23. Clark, 1995, Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice, Proc Natl Acad Sci USA, 92, 7794, 10.1073/pnas.92.17.7794 · DOI
  24. Weaver, 1989, Processing of hydrophobic pulmonary surfactant protein B in rat type II cells, Am J Physiol, 257, L100
  25. Liggins, 1968, Premature parturition after infusion of corticotrophin or cortisol into foetal lambs, J Endocrinol, 42, 323, 10.1677/joe.0.0420323 · DOI · Paper page
  26. Liggins, 1972, A controlled trail of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants, Pediatrics, 50, 515, 10.1542/peds.50.4.515 · DOI · Paper page
  27. Jobe, 1993, Pulmonary surfactant therapy, N Engl J Med, 328, 861, 10.1056/NEJM199303253281208 · DOI
  28. Manson, 1986, Mechanism of nitrofen teratogenesis, Environ Health Perspect, 70, 137, 10.1289/ehp.8670137 · DOI
  29. Baptista, 2005, Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia, J Pediatr Surg, 40, 658, 10.1016/j.jpedsurg.2005.01.034 · DOI
  30. Losada, 2000, Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids, Endocrinology, 141, 2166, 10.1210/endo.141.6.7522 · DOI
  31. Nogueira-Silva, 2012, Correia-Pinto local fetal lung renin-angiotensin system as a target to treat congenital diaphragmatic hernia, J Mol Med, 18, 231, 10.2119/molmed.2011.00210 · DOI
  32. Wideman, 2006, Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1), Proc Natl Acad Sci USA, 103, 13468, 10.1073/pnas.0600655103 · DOI
  33. Yang, 1998, GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor, Am J Physiol, 275, C675, 10.1152/ajpcell.1998.275.3.C675 · DOI
  34. Pérez-Tilve, 2007, Exendin-4 potently decreases ghrelin levels in fasting rats, Diabetes, 56, 143, 10.2337/db05-0996 · DOI
  35. Sherwood, 2000, The origin and function of the pituitary adenilate cyclase-activating polypeptide (PACAP)/glucagon superfamily, Endocr Rev, 21, 619
  36. Day, 2009, A new glucagon and GLP-1 co-agonist eliminates obesity in rodents, Nat Chem Biol, 5, 749, 10.1038/nchembio.209 · DOI · Paper page
  37. Hundertmark, 2002, 11β-hydroxysteroid dehydrogenase type 1: a new regulator of fetal lung maturation, Horm Metab Res, 34, 537, 10.1055/s-2002-35424 · DOI
  38. Hostettler, 2012, Local glucocorticoid production in the mouse lung is induced by immune cell stimulation, Alergy, 67, 227, 10.1111/j.1398-9995.2011.02749.x · DOI
  39. Thorens, 1993, Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9–39) an antagonist of the receptor, Diabetes, 42, 1678, 10.2337/diab.42.11.1678 · DOI
  40. Goldenberg, 2008, Epidemiology and causes of preterm birth, Lancet, 371, 75, 10.1016/S0140-6736(08)60074-4 · DOI · Paper page

Metadata

Authors
Romaní-Pérez, M., Outeiriño-Iglesias, V., Gil-Lozano, M., González-Matías, L. C., Mallo, F., & Vigo, E.
Affiliations
  • Laboratory of Endocrinology, Biomedical Research Centre (Cinbio, Centro Investigaciones Biomédicas), University of Vigo, Campus As Lagoas-Marcosende, E-36310 Vigo, Spain
  • Universidade de Vigo (ES)
Corresponding author
Vigo, Eva
ORCID
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2013-03-01
Volume
154
Issue
3
Pages
1144-1155
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/en.2012-1786
OpenAlex
W2004145580
Cited by
51
References
45
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 8 · 2014: 5 · 2013: 1
FWCI
4.04
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Surgery › Congenital Diaphragmatic Hernia Studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
GLP-1 receptor, surfactant proteins, surfactant protein A, surfactant protein B, exendin-4, liraglutide, fetal lung development, amniotic fluid, dexamethasone, glucocorticoids, neonatal lung maturation, sex differences, pregnancy
MeSH terms
Glucagon-Like Peptide-1 Receptor, Liraglutide, Exenatide, Animals, Animals, Newborn, Dexamethasone, Female, Fetus, Lung, Male, Peptides, Phenyl Ethers, Pregnancy, RNA, Messenger, Venoms, Up-Regulation, Rats, Sprague-Dawley, Receptors, Glucagon, Pulmonary Surfactant-Associated Proteins, Pulmonary Surfactant-Associated Protein A, Pulmonary Surfactant-Associated Protein B, Rats, Glucagon-Like Peptide 1

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