The DOI matches its Crossref record.
Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*
Abstract
Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration of insulin in the medium in order to evoke the down regulation phenomenon.
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Citations
Cited by
PHENOTYPIC STABILITY OF ADULT RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE*
Bissell, D. M., & Guzelian, P. S. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb29518.x · Cited by 342
Self-citationSmith, G. I., Polidori, D. C., Yoshino, M., Kearney, M. L., Patterson, B. W., Mittendorfer, B., & Klein, S. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136756 · Cited by 78
Mandarino, L., Baker, B., Rizza, R., Genest, J., & Gerich, J. (1984) · Diabetologia · doi:10.1007/bf00304850 · Cited by 41
Metadata
- Authors
- BLACKARD, W. G., GUZELIAN, P. S., & SMALL, M. E.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1978-08
- Volume
- 103
- Issue
- 2
- Pages
- 548-553
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2152498802
- Cited by
- 179
- References
- 0
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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How to cite
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- CoChat. (2026). Citation check: Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*. https://app.cochat.ai/papers/10.1210/endo-103-2-548
- The paper
- BLACKARD, W. G., GUZELIAN, P. S., & SMALL, M. E. (1978). Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*. Endocrinology. https://doi.org/10.1210/endo-103-2-548
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
