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Time-Trend Analysis of Plasma Cortisol Concentrations in the Fetal Sheep in Relation to Parturition*
Abstract
Using a cortisol RIA carefully validated for specificity in fetal ovine plasma, we studied plasma cortisol time-trend changes in eight chronically catheterized sheep fetuses in the last 22 days of gestation before the spontaneous onset of labor. Best fit exponential type curves were drawn for each individual fetus to define the time before the onset of labor at which fetal plasma cortisol was rising at different rates. Fetal plasma cortisol increased at a rate of 0.5 ng ml-1 day-1 as early as 17.1 days before labor in one fetus, whereas the mean value for all eight fetuses occurred 11.8 +/- 1.0 (SEM) days before labor. The rate of increase doubled to 1.0 ng cortisol ml-1 day-1 as early as 14.4 days before labor in one fetus, whereas the mean value for all eight fetuses occurred 9.3 +/- 0.9 days before labor. These findings suggest that the regulatory mechanisms responsible for the prelabor increase in fetal cortisol production are activated earlier in gestation than we previously thought.
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“Multiple factors initiate parturition, including fetal cortisol, maternal drop in progesterone, oxytocin, prostaglandin F2α and other endocrine factors56–59.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [57]
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Metadata
- Authors
- MAGYAR, D. M., FRIDSHAL, D., ELSNER, C. W., GLATZ, T., ELIOT, J., KLEIN, A. H., LOWE, K. C., BUSTER, J. E., & NATHANIELSZ, P. W.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1980-07
- Volume
- 107
- Issue
- 1
- Pages
- 155-159
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2128801555
- Cited by
- 189
- References
- 16
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Keywords
- childbirth, fetal sheep, gestation, labor onset, chronic catheterization
- MeSH terms
- Animals, Female, Fetal Blood, Gestational Age, Hydrocortisone, Pregnancy, Sheep
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