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In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*
Abstract
A 41-residue peptide purified as a corticotropin-releasing factor/beta-endorphin-releasing factor (CRF) in vitro was tested for its ability to stimulate the secretion of ACTH, beta-endorphin, and corticosterone in three animal groups: 1) unanesthesized rats bearing indwelling venous cannulae, 2) rats pretreated with chloropromazine plus morphine sulfate plus pentobarbital (CPZ-MS-Nb, and 3) rats with hypothalamic deafferentiations in the frontal and lateral retrochiasmatic areas. In all three bioassays iv administration of 0.1-10 micrograms CRF elicited a dose-related increase in plasma ACTH and beta-endorphin values over a 5- to 15-min period. Corticosterone secretion was also elevated but responded maximally with all doses of CRF tested. Pretreatment of CPZ-MS-Nb animals with 20 micrograms dexamethasone 4 h before assay abolished the CRF-induced hormone secretion. These data suggest that CRF may play a physiological role in the regulation of the hypothalamic-pituitary-adrenal axis.
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Citations
Cited by
Stress hormones: their interaction and regulation
Axelrod, J., & Reisine, T. D. (1984) · Science · doi:10.1126/science.6143403 · Cited by 1,527
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504
Self-citationPituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
Vaudry, D., Gonzalez, B. J., Basille, M., Yon, L., Fournier, A., & Vaudry, H. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01449-2 · Cited by 1,121
Maternal and Fetal Hypothalamic‐Pituitary‐Adrenal Axes During Pregnancy and Postpartum
MASTORAKOS, G., & ILIAS, I. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.016 · Cited by 621
Pich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565
Metadata
- Authors
- RIVIER, C., BROWNSTEIN, M., SPIESS, J., RIVIER, J., & VALE, W.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1982-01
- Volume
- 110
- Issue
- 1
- Pages
- 272-278
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2034584065
- Cited by
- 555
- References
- 0
- FWCI
- 21.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*. https://app.cochat.ai/papers/10.1210/endo-110-1-272
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- RIVIER, C., BROWNSTEIN, M., SPIESS, J., RIVIER, J., & VALE, W. (1982). In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*. Endocrinology. https://doi.org/10.1210/endo-110-1-272
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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