The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
ONTOGENESIS OF THE NUCLEAR 3,5,3′-TRIIODOTHYRONINE RECEPTOR IN THE HUMAN FETAL BRAIN
Abstract
A high-affinity T3 binding site with the binding specificity of the nuclear T3 receptor is present in the brain of the human fetus at midgestation. Its concentration was found to be very low at 10 weeks of gestation, and increased by a factor of 10 up to the 16th week, in coincidence with the period of neuroblast multiplication. Liver, heart, and lung also contained receptor. Both T4 and T3 were present in the brain, as measured by RIA. In other tissues, however, only T4 was detected, suggesting that brain T3 in the fetus arises from local 5'-deiodination of T4. The results suggest that the human fetal brain is a potential target of thyroid hormone at midgestation.
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Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Cited by
Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942
Alexander, E. K., Pearce, E. N., Brent, G. A., Brown, R. S., Chen, H., Dosiou, C., Grobman, W. A., Laurberg, P., Lazarus, J. H., Mandel, S. J., et al. (2017) · Thyroid® · doi:10.1089/thy.2016.0457 · Cited by 2,731
Abalovich, M., Amino, N., Barbour, L. A., Cobin, R. H., De Groot, L. J., Glinoer, D., Mandel, S. J., & Stagnaro-Green, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0141 · Cited by 931
Role of thyroid hormone during early brain development
Morreale de Escobar, G., Obregon, M., & Escobar del Rey, F. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.151u025 · Cited by 831
Maternal and Fetal Thyroid Function
Epstein, F. H., Burrow, G. N., Fisher, D. A., & Larsen, P. R. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311608 · Cited by 720
Metadata
- Authors
- BERNAL, J., & PEKONEN, F.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1984-02
- Volume
- 114
- Issue
- 2
- Pages
- 677-679
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2166896177
- Cited by
- 275
- References
- 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: ONTOGENESIS OF THE NUCLEAR 3,5,3′-TRIIODOTHYRONINE RECEPTOR IN THE HUMAN FETAL BRAIN. https://app.cochat.ai/papers/10.1210/endo-114-2-677
- The paper
- BERNAL, J., & PEKONEN, F. (1984). ONTOGENESIS OF THE NUCLEAR 3,5,3′-TRIIODOTHYRONINE RECEPTOR IN THE HUMAN FETAL BRAIN. Endocrinology. https://doi.org/10.1210/endo-114-2-677
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
