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Cited by 115Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

In Vivo and in Vitro Examination of an Autoregulatory Mechanism for Luteinizing Hormone-Releasing Hormone*

DEPAOLO, LOUIS V., KING, RITA A., CARRILLO, ALBERTO J.·1987·Endocrinology
DOI 10.1210/endo-120-1-272
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Abstract

Recent evidence has been presented that demonstrates the existence of ultrashort feedback circuits for a number of neuropeptides in the central nervous system. The present investigation was undertaken to examine the possible existence of an autoregulatory mechanism for LHRH. In the first experiment, long term ovariectomized rats bearing lateral ventricular and atrial cannulae received intracerebroventricular (icv) injections of saline or LHRH every hour from 1200-1500 h. Blood was collected at 10-min intervals from 1200-1500 h to assess the effects of icv LHRH on pulsatile LH and FSH release. After the 1500 h collection, LHRH was injected iv and blood was collected to determine the effects of icv LHRH on pituitary responsiveness to LHRH. Central injections of 0.1 pg and 1 ng LHRH, but not 10 pg LHRH, significantly suppressed mean LH levels, trough LH levels, and LH pulse frequency compared to those in saline-treated control rats. The amplitude of LH pulses was not significantly affected by any dose of LHRH. In contrast to LH, multiple icv injections of LHRH failed to alter pulsatile FSH release. Pituitary LH and FSH responses to iv LHRH injection were not suppressed by icv LHRH. In a second experiment, hourly icv injections of 1 ng LHRH into proestrous rats markedly suppressed preovulatory LH release only during the middle to latter phases of the surge. In a final study using an in vitro superfusion system, addition of a LHRH agonist to the superfusion medium at a concentrati…

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Crossref · 10.1210/endo-120-1-272

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Metadata

Authors
DEPAOLO, L. V., KING, R. A., & CARRILLO, A. J.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1987-01
Volume
120
Issue
1
Pages
272-279
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo-120-1-272
OpenAlex
W2047779052
Cited by
115
References
35
Citations by year
2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
FWCI
7.40
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 10202, HD-17807)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
gonadotropin-releasing hormone, negative feedback regulation, LH pulsatility, FSH release, luteinizing hormone surge, medial basal hypothalamus, median eminence, pituitary responsiveness, ovariectomized rats, proestrus, GnRH agonist
MeSH terms
Animals, Feedback, Female, Follicle Stimulating Hormone, Homeostasis, Hypothalamus, Injections, Intraventricular, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Ovariectomy, Ovulation, Pituitary Gland, Anterior, Potassium, Proestrus, Secretory Rate, Rats

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