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RETINOL-INDUCED STAGE SYNCHRONIZATION IN SEMINIFEROUS TUBULES OF THE RAT
Abstract
Vitamin A deficiency (VAD) in rats causes a progressive germ cell depletion and cessation of spermatogenesis resulting in seminiferous tubules which contain only Sertoli cells, spermatogonia and a small number of preleptotene spermatocytes. Spermatogenesis can be rapidly restored by the administration of retinol. Our preliminary studies suggested a partial stage synchronization of many seminiferous tubules in VAD male rats subsequently treated with retinol. To confirm this observation and to achieve a better synchronization, VAD rats received 2 SC injections of retinol suspended in sesame oil followed by daily oral administrations of 0.5 mg of retinol. In all rats an almost perfect synchronous stage development of seminiferous tubules evolved in a predictable manner and was maintained through 2 spermiations.
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Citations
Cited by
Retinoic acid regulates sex-specific timing of meiotic initiation in mice
Koubova, J., Menke, D. B., Zhou, Q., Capel, B., Griswold, M. D., & Page, D. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510813103 · Cited by 941
Self-citationde Rooij, D. G., & Grootegoed, J. A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80109-9 · Cited by 537
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq
Green, C. D., Ma, Q., Manske, G. L., Shami, A. N., Zheng, X., Marini, S., Moritz, L., Sultan, C., Gurczynski, S. J., Moore, B. B., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.025 · Cited by 521
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
“In vitamin A deficiency, the transition from A to A1 spermatogonia is blocked [42–44].”
BackgroundThe Sertoli cell: one hundred fifty years of beauty and plasticity
França, L. R., Hess, R. A., Dufour, J. M., Hofmann, M. C., & Griswold, M. D. (2016) · Andrology · doi:10.1111/andr.12165 · Cited by 419
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Metadata
- Authors
- MORALES, C., & GRISWOLD, M. D.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1987-07
- Volume
- 121
- Issue
- 1
- Pages
- 432-434
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2003668188
- Cited by
- 195
- References
- 0
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: RETINOL-INDUCED STAGE SYNCHRONIZATION IN SEMINIFEROUS TUBULES OF THE RAT. https://app.cochat.ai/papers/10.1210/endo-121-1-432
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- MORALES, C., & GRISWOLD, M. D. (1987). RETINOL-INDUCED STAGE SYNCHRONIZATION IN SEMINIFEROUS TUBULES OF THE RAT. Endocrinology. https://doi.org/10.1210/endo-121-1-432
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
