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EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT1
Abstract
The data presented in the current study suggest that the sterility which ensues from androgen treatment of prepubertal female rats is not the result of malfunction of the adenohypophysis. Rather, the pituitaries of such animals will respond to electrical stimulation of the hypothalamus by discharging sufficient gonadotropin to cause ovulation. It is further suggested from these experiments that there are two regions within the hypothalamus which control adenohypophyseal gonadotropin secretion: (a) a region responsible for activating the cyclic discharge of ovulating hormone: the anterior preoptic (suprachiasmatic) area of the hypothalamus, and (b) a region independently responsible for the tonic discharge of luteinizing hormone in a sufficient quantity to cause estrogen secretion but not ovulation: the arcuate-ventromedial nuclei complex of the median eminence. Evidence is presented which suggests that prepubertal androgen treatment deleteriously alters the function of the “ovulation controlling” preoptic region of the hypothalamus.
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Cited by
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D., & Keiner, M. (1973) · Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984
Estradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885
Multimodal Influence of Estrogen upon Gonadotropin-Releasing Hormone Neurons
Herbison, A. E. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0332 · Cited by 619
Metadata
- Authors
- BARRACLOUGH, C. A., & GORSKI, R. A.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1961-01
- Volume
- 68
- Issue
- 1
- Pages
- 68-79
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2147102264
- Cited by
- 388
- References
- 0
- FWCI
- 25.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT1. https://app.cochat.ai/papers/10.1210/endo-68-1-68
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- BARRACLOUGH, C. A., & GORSKI, R. A. (1961). EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT1. Endocrinology. https://doi.org/10.1210/endo-68-1-68
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
