Dihydrotestosterone Formation in Fetal Tissues of the Rabbit and Rat
Abstract
The rate of conversion of testosterone- l,2-3H to dihydrotestosterone-3H has been measured in a variety of tissues in rabbit embryos from 17 days of development to 3 days following birth and in rat embryos from 15 days of gestation to 4 days after delivery. In the rabbit embryo dihydrotestosterone formation was rapid only in the urogenital sinus and urogenital tubercle of both sexes at the earliest stages studied and was not measurable in wolffian and mullerian ducts until after gender identification was easily demonstrable. A similar pattern of development was observed in the rat embryo. These findings suggest that the capacity to form dihydrotestosterone in urogenital sinus and tubercle is not the result of androgen action but rather an inherent or obligatory property of the tissue and may fulfill in part the function of an initial androgen receptor in these organs. In contrast, in the mullerian and wolffian ducts the ability to form dihydrotestosterone appears to be acquired after the initial stages of differentiation are complete and may actually be the result of hormonal action. (Endocrinology89:659,1971)
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Testosterone, reduced by 5 reductase to dihydrotestosterone, is important for development of external genitalia and the prostate.
“Testosterone, reduced by the enzyme 5 reductase to dihydrotestosterone, is impor- tant for development of external genitalia and the prostate (Wilson and Lasnitzki 1971).”
From Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat. (2002) · cites this paper as Wilson and Lasnitzki 1971
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The hormonal-control of sexual development
Wilson, J. D., George, F. W., & Griffin, J. E. (1981) · Science · doi:10.1126/science.7010602 · Cited by 451 · see citing works
Self-citationMolecular genetics of steroid 5 alpha-reductase 2 deficiency
Thigpen, A. E., Davis, D. L., Milatovich, A., Mendonca, B. B., Imperato-McGinley, J., Griffin, J. E., Francke, U., Wilson, J. D., & Russell, D. W. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115954 · Cited by 422 · see citing works
Self-citationSteroid 5α-Reductase 2 Deficiency*
WILSON, J. D., GRIFFIN, J. E., & RUSSELL, D. W. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-5-577 · Cited by 346 · see citing works
Self-citationMoore, R. J., & Wilson, J. D. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33036-3 · Cited by 99 · see citing works
Self-citationHotchkiss, A. K., Ostby, J. S., Vandenburgh, J. G., & Gray, L. E. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s3435 · Cited by 82 · see citing works
- Authors
- WILSON, J. D., & LASNITZKI, I.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1971-09
- Volume
- 89
- Issue
- 3
- Pages
- 659-668
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2134676547
- Cited by
- 173
- References
- 0
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2020: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone suppression, fetal development, urogenital sinus, Wolffian duct, Müllerian ducts, androgen receptor, sexual differentiation, rabbit embryo, rat embryo, androgen action
- MeSH terms
- Androstanes, Animals, Chromatography, Thin Layer, Cloaca, Crystallization, Embryo, Mammalian, Female, Fetus, Genitalia, Male, Male, Mullerian Ducts, Pregnancy, Rabbits, Dihydrotestosterone, Sterols, Androgen-Insensitivity Syndrome, Testosterone, Tritium, Wolffian Ducts, 17-Ketosteroids, Rats, In Vitro Techniques
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