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Granulosa Cell Maturation in the Rat: Increased Binding of Human Chorionic Gonadotropin Following Treatment with Follicle-Stimulating Hormone in Vivo11
Abstract
The role of follicle-stimulating hormone (FSH) in ovarian development was studied in immature rats. Autoradiographic analysis of gonadotropin binding sites revealed that FSH bound to granulosa cells while human chorionic gonadotropin (hCG) bound to thecal and interstitial cells in 25-day-old rats. Following 2 days of treatment with rat FSH (rFSH), hCG binding was observed in the granulosa cells of stimulated follicles. Histochemical localization of 3β-hydroxysteroid dehydrogenase activity also was apparent in granulosa cells from animals treated with FSH. Granulosa cells from rats treated with either hCG or diethylstilbestrol for 2 days failed to show consistent hCG binding. Isolated granulosa cells from intact and hypophysectomized rats treated with FSH demonstrated a greater binding capacity for hCG than granulosa cells removed from saline-treated animals. These results suggest that FSH administered in vivo may act on granulosa cells to induce or activate receptors for I_H (hCG) and 3β-hydroxysteroid dehydrogenase activity. (Endocrinology95: 818, 1974)
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Cited by
Ovarian antral folliculogenesis during the human menstrual cycle: A review
Baerwald, A. R., Adams, G. P., & Pierson, R. A. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr039 · Cited by 487
Pituitary control of ovarian function–concepts derived from gonadotrophin therapy
Brown, J. B. (1978) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1978.tb00011.x · Cited by 320
Induction of hot flashes in premenopausal women treated with a long-acting GnRH agonist
DEFAZIO, J., MELDRUM, D. R., LAUFER, L., VALE, W., RIVIER, J., LU, J. K. H., & JUDD, H. L. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-3-445 · Cited by 84
Metadata
- Authors
- ZELEZNIK, A. J., MIDGLEY, A. R., & REICHERT, L. E.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1974-09
- Volume
- 95
- Issue
- 3
- Pages
- 818-825
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2083158575
- Cited by
- 394
- References
- 0
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- ZELEZNIK, A. J., MIDGLEY, A. R., & REICHERT, L. E. (1974). Granulosa Cell Maturation in the Rat: Increased Binding of Human Chorionic Gonadotropin Following Treatment with Follicle-Stimulating Hormone in Vivo11. Endocrinology. https://doi.org/10.1210/endo-95-3-818
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