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Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity
Abstract
Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on beta-cell function, respectively referred to as glucotoxicity and lipotoxicity. Over time, both contribute to the progressive deterioration of glucose homeostasis characteristic of type 2 diabetes. The mechanisms of glucotoxicity involve several transcription factors and are, at least in part, mediated by generation of chronic oxidative stress. Lipotoxicity is probably mediated by accumulation of a cytosolic signal derived from the fatty acid esterification pathway. Our view that hyperglycemia is a prerequisite for lipotoxicity is supported by several recent studies performed in our laboratories. First, prolonged in vitro exposure of isolated islets to fatty acids decreases insulin gene expression in the presence of high glucose concentrations only, and glucose is rate-limiting for the incorporation of fatty acids into neutral lipids. Second, normalization of blood glucose in Zucker diabetic fatty rats prevents accumulation of triglycerides and impairment of insulin gene expression in islets, whereas normalization of plasma lipid levels is without effect. Third, high-fat feeding in Goto-Kakizaki rats significantly impairs glucose-induced insulin secretion in vitro, whereas a similar diet has no effect in normoglycemic animals. We propose that chronic hyperglycemia, independent of hyperlipidemia, is toxic for beta-cell function, whereas chronic hyperlipidemia is deleterious only in the context of concomitant hyperglycemia.
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“Prior studies have linked loss of β-cell identity and dedifferentiation to β-cell dysfunction in models of insulin resistance and reduced islet mass [38, 40].”
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“Islet inflammatory stress increases islet miR-21 expression and is associated with the altered β-cell identity [38].”
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ResultMolecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction
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BackgroundUCP-2 and UCP-3 Proteins Are Differentially Regulated in Pancreatic Beta-Cells
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“Furthermore, chronic high fatty acid concentrations may be beta-cell toxic in the context of concomitant hyperglycemia, referred to as glucolipotoxicity [1,2,5].”
BackgroundCerf, M. E., Williams, K. G., Chapman, C. S., & Louw, J. (2007) · Pancreas · doi:10.1097/mpa.0b013e31802ee9ae · Cited by 36
The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth
Pelengaris, S., & Khan, M. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.5.623 · Cited by 41
“In animal models of diabetes, impaired glucose-stimulated insulin secretion (GSIS) is associated with loss of β cell differentiation markers and proteins involved in glucose stimulus–secretion coupling; accompanied by β cell hypertrophy and increased expression of Myc [135-137].”
BackgroundMukhuty, A., Fouzder, C., Mukherjee, S., Malick, C., Mukhopadhyay, S., Bhattacharya, S., & Kundu, R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.022 · Cited by 42
Shodehinde, S., Ademiluyi, A., Oboh, G., & Akindahunsi, A. (2015) · Life Science · doi:10.1016/j.lfs.2015.03.026 · Cited by 38
Metabolomics applied to the pancreatic islet
Gooding, J. R., Jensen, M. V., & Newgard, C. B. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.06.013 · Cited by 37
Mega, C., Vala, H., Rodrigues‐Santos, P., de Oliveira, J. B. F., Teixeira, F. J., Fernandes, R., Reis, F., & Teixeira‐Lemos, E. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-42 · Cited by 35
“Hyperglycaemia, per se, may have a detrimental effect on secretory function, − “glucotoxicity” –, which induces increased apoptosis in pancreatic islets; in addition, the abnormal lipid profile commonly observed in these subjects may be associated with functional impairment of the islet – “lipotoxicity” [5-8].”
BackgroundTLR4 is required for the obesity-induced pancreatic beta cell dysfunction
Li, J., Chen, L., Zhang, Y., Zhang, W. J., Xu, W., Qin, Y., Xu, J., & Zou, D. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt092 · Cited by 37
Chen, Z., & Wen, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.973655 · Cited by 48
Li, J., Wu, N., Cheng, X. J., Chen, H., Yang, X., & Liu, C. (2019) · Islets · doi:10.1080/19382014.2019.1690944 · Cited by 43
Hou, X., Liu, J., Song, J., Wang, C., Liang, K., Sun, Y. S., Ma, Z., Yang, W., Li, C., Zhang, X., et al. (2015) · Journal of Diabetes Research · doi:10.1155/2016/8797316 · Cited by 35
“Many factors including hyperglycemia and elevated free fatty acid accelerate β cell deterioration [3].”
BackgroundFavre, D., Niederhäuser, G., Fahmi, D., Plaisance, V., Brajkovic, S., Beeler, N., Allagnat, F., Haefliger, J., Regazzi, R., Waeber, G., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2165-x · Cited by 38
Chitooligosaccharides protect pancreatic β-cells from hydrogen peroxide-induced deterioration
Karadeniz, F., Artan, M., Kong, C., & Kim, S. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.04.046 · Cited by 42
Urolithins: Diet-Derived Bioavailable Metabolites to Tackle Diabetes
Raimundo, A., Ferreira, S., Tomás-Barberán, F. A., dos Santos, C. N., & Menezes, R. (2021) · Nutrients · doi:10.3390/nu13124285 · Cited by 40
Metadata
- Authors
- Poitout, V., & Robertson, R. P.
- Affiliations
- University of Washington (US)
- Corresponding author
- Poitout, Vincent
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2002-02
- Volume
- 143
- Issue
- 2
- Pages
- 339-342
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1971701221
- Cited by
- 743
- References
- 0
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 11 · 2022: 13 · 2021: 24 · 2020: 23 · 2019: 16 · 2018: 22 · 2017: 24 · 2016: 20 · 2015: 49 · 2014: 41 · 2013: 41 · 2012: 45
- FWCI
- 37.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R-01-DK-38325, R01 DK 58096)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- type 2 diabetes, beta-cell dysfunction, glucotoxicity, lipotoxicity, hyperglycemia, hyperlipidemia, oxidative stress, transcription factors, fatty acid esterification, insulin gene expression, glucose-stimulated insulin secretion, triglyceride accumulation, high-fat diet, islets
- MeSH terms
- Animals, Chronic Disease, Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Hyperlipidemias, Islets of Langerhans
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