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Cited by 229Ion channel regulation and functionIon Channels and ReceptorsCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 769 of the 769 references it cites were found in a registry or an index.

Ion Channels and Signaling in the Pituitary Gland

Open access
Stojilkovic, Stanko S., Tabak, Joël, Bertram, Richard·2010·Endocrine Reviews
DOI 10.1210/er.2010-0005PMC PMC3365841
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Abstract

Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium, calcium, potassium, and chloride channels and fire action potentials spontaneously, accompanied by a rise in intracellular calcium.In some cells, spontaneous electrical activity is sufficient to drive the intracellular calcium concentration above the threshold for stimulus-secretion and stimulus-transcription coupling.In others, the function of these action potentials is to maintain the cells in a responsive state with cytosolic calcium near, but below, the threshold level.Some pituitary cells also express gap junction channels, which could be used for intercellular Ca 2ϩ signaling in these cells.Endocrine cells also express extracellular ligand-gated ion channels, and their activation by hypothalamic and intrapituitary hormones leads to amplification of the pacemaking activity and facilitation of calcium influx and hormone release.These cells also express numerous G protein-coupled receptors, which can stimulate or silence electrical activity and action potential-dependent calcium influx and hormone release.Other members of this receptor family can activate calcium channels in the endoplasmic reticulum, leading to a cell type-specific modulation of electrical activity.This review summarizes recent findings in this field and our current understanding of the complex relationship between voltage-gated ion channels, ligand-gated ion channels, gap junction channels, and G protein-coupled receptors in pituitary cells.(Endocrine Reviews 31: 845-915, 2010) I. Introduction II.Pituitary Cell Types A. POMC-producing cells B. Heterodimeric glucoprotein-producing cells C. GH-and PRL-producing cells D. Nonsecretory cells III.Ion Channels Expressed in Pituitary Cells A. Voltage-gated channels B. Chloride channels and transporters C. Channels expressed in and controlled by the endoplasmic reticulum IV.Spontaneous Electrical Activity A. Spiking and bursting B. Pacemaking mechanisms C. Channels involved in spike depolarization D. A mechanism for bursting E. Functional roles of spontaneous spiking V. Signaling by Gap Junction Channels A. Connexins B. Pannexins VI.Signaling by Receptor Channels A. Cys-loop family of receptor channels B. Glutamate receptor channels C. Purinergic receptor channels VII.Role of GPCRs in the Regulation of Electrical Activity A. Stimulation of electrical activity by GPCRs B. Inhibition of electrical activity by GPCRs VIII.Calcium-Mobilizing Receptors and Electrical Activity A. The dynamics of Ca 2ϩ release B. Calcium mobilization and secretion IX.

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Research works printed but not linked: 3

  1. Shen, 2009, Thymol-evoked Ca+ mobilization and ion currents in pituitary GH3 cells., Nat Prod Commun, 4, 749
  2. Vankelecom, 1997, Paracrine communication in the anterior pituitary as studied in reaggregate cell cultures., Microsc Res Tech, 39, 150, 10.1002/(SICI)1097-0029(19971015)39:2<150::AID-JEMT6>3.0.CO;2-P · DOI
  3. Kleuss, 1995, Somatostatin modulates voltage-dependent Ca2+ channels in GH3 cells via a specific G(o) splice variant., Ciba Found Symp, 190, 171

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Metadata

Authors
Stojilkovic, S. S., Tabak, J., & Bertram, R.
Affiliations
  • Section on Cellular Signaling (S.S.S.), Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-4510;
  • Department of Biological Science (J.T.) Florida State University, Tallahassee, Florida 32306
  • Florida State University (US)
ORCID
Bertram, Richard
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2010-12-01
Volume
31
Issue
6
Pages
845-915
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2010-0005
PMC
PMC3365841
OpenAlex
W1991106585
Cited by
229
References
769
Citations by year
2026: 4 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 27 · 2021: 13 · 2020: 23 · 2019: 15 · 2018: 7 · 2017: 20 · 2016: 21 · 2015: 17 · 2014: 14 · 2013: 13 · 2012: 12
FWCI
1.06
Type
journal article
Language
en
Open access
Locations
  • Endocrine Reviews (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (DK 43,200)
  • National Institute on Drug Abuse (R01DA019356, DA19356)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 43200, R01DK043200)
  • National Institute of Child Health and Human Development
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
pituitary gland, voltage-gated ion channels, ligand-gated ion channels, gap junction channels, G protein-coupled receptors, spontaneous electrical activity, action potential, intracellular calcium signaling, hormone secretion, pacemaking, connexins, pannexins, Cys-loop receptors, glutamate receptors, purinergic receptors, endoplasmic reticulum calcium channels
MeSH terms
Action Potentials, Calcium, Humans, Ion Channels, Pituitary Gland, Signal Transduction, Patch-Clamp Techniques, Receptors, G-Protein-Coupled

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