The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
A Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor Cells
Abstract
Human pituitary adenomas are the most common intracranial neoplasm. Typically monoclonal in origin, a somatic mutation is a prerequisite event in tumor development. To identify underlying pathogenetic mechanisms in tumor formation, we compared the difference in gene expression between normal human pituitary tissue and clinically nonfunctioning pituitary adenomas by cDNA-representational difference analysis. We cloned a cDNA, the expression of which was absent in these tumors, that represents a novel transcript from the previously described MEG3, a maternal imprinting gene with unknown function. It was expressed in normal human gonadotrophs, from which clinically nonfunctioning pituitary adenomas are derived. Additional investigation by Northern blot and RT-PCR demonstrated that this gene was also not expressed in functioning pituitary tumors as well as many human cancer cell lines. Moreover, ectopic expression of this gene inhibits growth in human cancer cells including HeLa, MCF-7, and H4. Genomic analysis revealed that MEG3 is located on chromosome 14q32.3, a site that has been predicted to contain a tumor suppressor gene involved in the pathogenesis of meningiomas. Taken together, our data suggest that MEG3 may represent a novel growth suppressor, which may play an important role in the development of human pituitary adenomas.
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Cites
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Pituitary Tumor Transforming Gene (PTTG) Expression in Pituitary Adenomas
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Self-citationStructure, Expression, and Function of Human Pituitary Tumor-Transforming Gene (PTTG)
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microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer
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Long non-coding RNAs and complex diseases: from experimental results to computational models
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Self-citationThe functional role of long non-coding RNAs and epigenetics
Cao, J. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-11 · Cited by 357
Zhang, X., Rice, K., Wang, Y., Chen, W., Zhong, Y., Nakayama, Y., Zhou, Y., & Klibanski, A. (2010) · Endocrinology · doi:10.1210/en.2009-0657 · Cited by 325
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Metadata
- Authors
- Zhang, X., Zhou, Y., Mehta, K. R., Danila, D. C., Scolavino, S., Johnson, S. R., & Klibanski, A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-11-01
- Volume
- 88
- Issue
- 11
- Pages
- 5119-5126
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2164252048
- Cited by
- 435
- References
- 37
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
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