The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Effects of Changes in Body Weight and Insulin Resistance on Inflammation and Endothelial Function in Morbid Obesity after Bariatric Surgery
Open accessAbstract
Metabolic alterations such as insulin resistance are thought to underlie the endothelial dysfunction and low grade inflammation found in morbid obesity. Twenty-six morbidly obese patients, aged 39.0 +/- 10.0 (mean +/- sd), were evaluated before and 4.2 +/- 0.8 months after bariatric surgery. A marked increment in the insulin sensitivity index (S(I)) and the endothelium-dependent vasodilatory response in a dorsal hand vein was observed after weight loss following bariatric surgery. Circulating levels of E-selectin, P-selectin, plasminogen activator inhibitor-1, and von Willebrand factor, which were higher than those in the control group, decreased significantly after surgery. Plasma vascular cell adhesion molecule-1, angiotensin-converting enzyme, intercellular adhesion molecule-1, thrombomodulin, and plasma and intraplatelet cGMP levels did not change after weight loss. All inflammatory markers were higher in morbidly obese patients. After surgery, C- reactive protein and sialic acid diminished, whereas circulating levels of IL-6, TNF-alpha, and its soluble receptors did not. Positive correlations were found between changes in adiposity and S(I) and changes in C-reactive protein and between changes in sialic acid and changes in endothelial function. In conclusion, a marked improvement in S(I), endothelial function, and low grade inflammation was observed in the weight-losing, morbidly obese patients after bariatric surgery. S(I) and adiposity appear to play roles in obesity-related, low grade inflammation that contribute to the endothelial dysfunction observed in morbid obesity.
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Cites
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Acute-Phase Proteins and Other Systemic Responses to Inflammation
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“However, reports assessing in vivo vascular reactivity in humans demonstrated that the endothelium-dependent vasodilatory response was altered in experimental mild hyperinsulinemic subjects (10) and in obese individuals who displayed IR (11, 12).”
BackgroundHyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
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“Finally, because the possible correlation between venous and arterial dysfunction remains to be demonstrated in morbid obesity, discrepancies with previous reports in the associations between inflammatory markers and vasodilatory response (49, 50) may be related to different study protocols, i.”
ResultFernandez-Real, J.-M., Vayreda, M., Richart, C., Gutierrez, C., Broch, M., Vendrell, J., & Ricart, W. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7305 · Cited by 567
Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women
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“In contrast, the absence of changes in these inflammatory cytokines has been recently reported in very active, weightlosing patients induced by a very low calorie diet (43) or bariatric surgery (21, 22), suggesting a role of the metabolic stress of relative starvation in the inflammatory response (44).”
BackgroundAdipose tissue, insulin action and vascular disease: inflammatory signals
Yudkin, J. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802496 · Cited by 311 · cited 1×
“According to previous reports, elevation of both the acute phase mediators, CRP and SA, and the proinflammatory cytokines, TNF and IL-6, has characterized morbid obesity as a low grade inflammatory process of the innate immune system (39, 40).”
Background
Cited by
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806
Neurological consequences of obesity
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Obesity and inflammation: the effects of weight loss
Forsythe, L. K., Wallace, J. M. W., & Livingstone, M. B. E. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138732 · Cited by 381
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c170040 · Cited by 373
Poirier, P., Cornier, M.-A., Mazzone, T., Stiles, S., Cummings, S., Klein, S., McCullough, P. A., Ren Fielding, C., & Franklin, B. A. (2011) · Circulation · doi:10.1161/cir.0b013e3182149099 · Cited by 339
Metadata
- Authors
- Vázquez, L. A., Pazos, F., Berrazueta, J. R., Fernández-Escalante, C., García-Unzueta, M. T., Freijanes, J., & Amado, J. A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-01
- Volume
- 90
- Issue
- 1
- Pages
- 316-322
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2069759393
- Cited by
- 205
- References
- 14
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Effects of Changes in Body Weight and Insulin Resistance on Inflammation and Endothelial Function in Morbid Obesity after Bariatric Surgery. https://app.cochat.ai/papers/10.1210/jc.2003-032059
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- Vázquez, L. A., Pazos, F., Berrazueta, J. R., Fernández-Escalante, C., García-Unzueta, M. T., Freijanes, J., & Amado, J. A. (2005). Effects of Changes in Body Weight and Insulin Resistance on Inflammation and Endothelial Function in Morbid Obesity after Bariatric Surgery. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2003-032059
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
