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Cited by 76Bone health and osteoporosis researchHormonal and reproductive studiesSexual Differentiation and Disorders

Perturbed Sex Steroid Status in Men with Idiopathic Osteoporosis and Their Sons

Van Pottelbergh, I., Goemaere, S., Zmierczak, H., Kaufman, J. M.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-032081
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Abstract

We reported previously that a gender-specific defect of acquisition of lumbar bone mass plays an important role in the pathogenesis of male idiopathic osteoporosis (IO) and that there is a strong heritability of this maturational defect, which is particularly manifest in sons of men with IO. A hypothetical role of an altered sex steroid status and/or of a (TTTA)(n)- repeat polymorphism of the aromatase (CYP19) gene in male IO remains to be established. We evaluated bone mineral density (BMD) at the lumbar spine and femoral neck in 64 male IO probands (selected on the basis of a z-score of -2 or less), 21 of their sons, 41 of their brothers, and 126 healthy, age-matched controls. Serum testosterone (T), estradiol (E(2)), and SHBG levels were measured by immunoassays. Free T (FT) and free E(2) (FE(2)) levels were calculated from total T, E(2), SHBG, and albumin concentrations using a previously validated equation. Probands, sons, and brothers had lower body weight than age-matched controls, with mean differences of 5.0, 4.6, and 4.0 kg, respectively. In probands, sons, and brothers, SHBG levels were higher compared with controls. Significantly lower FE(2) levels were observed in probands and sons compared with their respective controls (P < 0.05 and P < 0.01, respectively). The brothers had nonsignificantly lower FE(2) levels compared with their controls. In the total group of sons with significantly lower FE(2) levels, tertile analysis according to lumbar spine BMD showed that…

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  • Older men's osteoporosis tracks low estrogen more closely than low androgen.

    “osteoporosis in older men is more closely associated with low estrogen than with low androgen levels”

    From Pathogenesis of osteoporosis: concepts, conflicts, and prospects (2005) · cites this paper as [17]

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Authors
Van Pottelbergh, I., Goemaere, S., Zmierczak, H., & Kaufman, J. M.
Affiliations
Ghent University Hospital (BE)
ORCID
Kaufman, J. M.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-10
Volume
89
Issue
10
Pages
4949-4953
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-032081
OpenAlex
W2116719253
Cited by
76
References
5
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 8 · 2012: 4
FWCI
7.13
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
idiopathic osteoporosis, free estradiol, free testosterone, sex hormone-binding globulin, heritability, lumbar spine bone mineral density, femoral neck bone mineral density, body mass index, body weight, estrogen deficiency
MeSH terms
Adult, Aromatase, Estradiol, Genotype, Humans, Male, Middle Aged, Nuclear Family, Osteoporosis, Regression Analysis, Sex Hormone-Binding Globulin, Testosterone, Bone Density

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