Clinical and Economic Outcomes of Thyroid and Parathyroid Surgery in Children
Abstract
Context: Clinical and economic outcomes after thyroidectomy/parathyroidectomy in adults have demonstrated disparities based on patient age and race/ethnicity; there is a paucity of literature on pediatric endocrine outcomes. Objective: The objective was to examine the clinical and demographic predictors of outcomes after pediatric thyroidectomy/parathyroidectomy. Design: This study is a cross-sectional analysis of Healthcare Cost and Utilization Project–National Inpatient Sample hospital discharge information from 1999–2005. All patients who underwent thyroidectomy/parathyroidectomy were included. Bivariate and multivariate analyses were performed to identify independent predictors of patient outcomes. Subjects: Subjects included 1199 patients 17 yr old or younger undergoing thyroidectomy/parathyroidectomy. Main Outcome Measures: Outcome measures included in-hospital patient complications, length of stay (LOS), and inpatient hospital costs. Results: The majority of patients were female (76%), aged 13–17 yr (71%), and White (69%). Whites were more often in the highest income group (80% vs. 8% for Hispanic and 6% for Black; P < 0.01) and had private/HMO insurance (76% vs. 10% for Hispanic and 5% for Black; P < 0.001) rather than Medicaid (13% vs. 32% for Hispanic and 41% for Black; P < 0.001). Ninety-one percent of procedures were thyroidectomies and 9% parathyroidectomies. Children aged 0–6 yr had higher complication rates (22% vs. 15% for 7–12 yr and 11% for 13–17 yr; P < 0.01), LOS (3.3 d vs. 2.3 for 7–12 yr and 1.8 for 13–17 yr; P < 0.01), and higher costs. Compared with children from higher-income families, those from lower-income families had higher complication rates (11.5 vs. 7.7%; P < 0.05), longer LOS (2.7 vs. 1.7 d; P < 0.01), and higher costs. Children had higher endocrine-specific complication rates than adults after parathyroidectomy (15.2 vs. 6.2%; P < 0.01) and thyroidectomy (9.1 vs. 6.3%; P < 0.01). Conclusions: Children undergoing thyroidectomy/parathyroidectomy have higher complication rates than adult patients. Outcomes were optimized when surgeries were performed by high-volume surgeons. There appears to be disparity in access to high-volume surgeons for children from low-income families, Blacks, and Hispanics.
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Thyroidectomy is associated with a higher complication rate in children than in adults.
“Thyroidectomy is an effective treatment for GD, but it is associated with a higher complication rate in children than in adults (316)(317)(318).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [316]
Thyroidectomy is an effective treatment for GD.
“Thyroidectomy is an effective treatment for GD, but it is associated with a higher complication rate in children than in adults (316)(317)(318).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [316]
Surgical complication rates are higher in children than in adults, with higher rates in younger than in older children.
“Surgical complication rates are higher in children than in adults, with higher rates in younger than in older children (316,318).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [316]
Postoperatively, younger children also appear to be at higher risk for transient hypoparathyroidism than adolescents or adults.
“Postoperatively, younger children also appear to be at higher risk for transient hypoparathyroidism than adolescents or adults (316,318).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [316]
Complication rates are 2-fold higher when thyroidectomy is performed by pediatric or general surgeons who do not have extensive current experience in this procedure than when performed by high-volume thyroid surgeons.
“In addition, complication rates are 2-fold higher when thyroidectomy is performed by pediatric or general surgeons who do not have extensive current experience in this procedure than when performed by high-volume thyroid surgeons (316).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [316]
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References 25 · Cited by 329
- Authors
- Sosa, J. A., Tuggle, C. T., Wang, T. S., Thomas, D. C., Boudourakis, L., Rivkees, S., & Roman, S. A.
- Affiliations
- Yale University (US)
- Medical College of Wisconsin (US)
- Corresponding author
- Wang, Tracy S.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-08-01
- Volume
- 93
- Issue
- 8
- Pages
- 3058-3065
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2140998061
- Cited by
- 329
- References
- 25
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 16 · 2023: 12 · 2022: 30 · 2021: 40 · 2020: 27 · 2019: 18 · 2018: 19 · 2017: 18 · 2016: 26 · 2015: 20 · 2014: 13 · 2013: 19 · 2012: 17
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Healthcare Policy and Management
- Keywords
- pediatric thyroidectomy, postoperative complications, length of hospital stay, hospital costs, socioeconomic disparities, insurance status, Medicaid, household income, age differences, racial and ethnic disparities, pediatric surgery outcomes, hospitalization, hospital readmission, hospital discharge disposition
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Infant, Newborn, Insurance, Health, Length of Stay, Male, Postoperative Complications, Socioeconomic Factors, Thyroidectomy, Parathyroidectomy
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