CoChat
Sign Up
Cited by 363Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and DisordersImmunodeficiency and Autoimmune Disorders

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Mortality in Women with Turner Syndrome in Great Britain: A National Cohort Study

Schoemaker, Minouk J., Swerdlow, Anthony J., Higgins, Craig D., Wright, Alan F., Jacobs, Patricia A.·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-1049
Open this paper in CoChat — free account

Abstract

CONTEXT: Turner syndrome is characterized by complete or partial X chromosome monosomy. It is associated with substantial morbidity, but mortality risks and causes of death are not well described. OBJECTIVES: Our objective was to investigate mortality and causes of death in women with Turner syndrome. DESIGN AND SETTING: We constructed a cohort of women diagnosed with Turner syndrome at almost all cytogenetic centers in Great Britain and followed them for mortality. PATIENTS: A total of 3,439 women diagnosed between 1959-2002 were followed to the end of 2006. OUTCOME MEASURES: Standardized mortality ratios (SMRs) and absolute excess risks were evaluated. RESULTS: In total, 296 deaths occurred. Mortality was significantly raised overall [SMR = 3.0; 95% confidence interval (CI) = 2.7-3.4] and was raised for nearly all major causes of death. Circulatory disease accounted for 41% of excess mortality, with greatest SMRs for aortic aneurysm (SMR = 23.6; 95% CI = 13.8-37.8) and aortic valve disease (SMR = 17.9; 95% CI = 4.9-46.0), but SMRs were also raised for other circulatory conditions. Other major contributors to raised mortality included congenital cardiac anomalies, diabetes, epilepsy, liver disease, noninfectious enteritis and colitis, renal and ureteric disease, and pneumonia. Absolute excess risks of death were considerably greater at older than younger ages. CONCLUSIONS: Mortality in women with Turner syndrome is 3-fold higher than in the general population, is raised for almost all major causes of death, and is raised at all ages, with the greatest excess mortality in older adulthood. These risks need consideration in follow-up and counseling of patients and add to reasons for continued follow-up and preventive measures in adult, not just pediatric, care.

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.2008-1049

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 32 references

1 of the 32 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Items 201–300 of 363

Related

See all

Metadata

Authors
Schoemaker, M. J., Swerdlow, A. J., Higgins, C. D., Wright, A. F., & Jacobs, P. A.
Affiliations
  • Institute of Cancer Research (GB)
  • MRC Human Genetics Unit (GB)
  • Salisbury District Hospital (GB)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-12
Volume
93
Issue
12
Pages
4735-4742
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-1049
OpenAlex
W2057862933
Cited by
360
References
32
Citations by year
2026: 14 · 2025: 29 · 2024: 25 · 2023: 24 · 2022: 30 · 2021: 18 · 2020: 52 · 2019: 28 · 2018: 14 · 2017: 18 · 2016: 12 · 2015: 16 · 2014: 15 · 2013: 15 · 2012: 17
FWCI
6.27
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
Turner syndrome, mortality, causes of death, standardized mortality ratio, aortic aneurysm, aortic valve disease, circulatory diseases, congenital heart disease, diabetes mellitus, epilepsy, liver disease, kidney disease, pneumonia, adult follow-up, X chromosome monosomy
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aortic Aneurysm, Aortic Valve Insufficiency, Cardiovascular Diseases, Cause of Death, Female, United Kingdom, Humans, Karyotyping, Middle Aged, Neoplasms, Retrospective Studies, Risk, Turner Syndrome, Women, Cohort Studies, Confidence Intervals, Cytogenetic Analysis, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review