Sleep-disordered breathing is increased in obese adolescents with craniopharyngioma compared with obese controls
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CONTEXT: Retrospective studies suggest that adolescents with craniopharyngioma and hypothalamic obesity have increased sleep-disordered breathing (SDB). OBJECTIVES: The objectives of this study were to compare the prevalence of SDB in adolescents with craniopharyngioma-related obesity compared with body mass index (BMI)-matched controls and to explore possible relationships between SDB, insulin resistance, and adipocytokines. DESIGN: This was a cross-sectional study of obese craniopharyngioma and obese control adolescents. SETTING: Subjects were evaluated in the clinical investigation unit at the Hospital for Sick Children, Toronto. PATIENTS: Fifteen patients with craniopharyngioma-related obesity and 15 BMI-matched controls were recruited and tested. INTERVENTIONS: Each subject underwent fasting blood work, frequent sampled iv glucose tolerance test, polysomnography, and abdominal magnetic resonance imaging with calculation of visceral and sc adipose tissue. MAIN OUTCOME MEASURES: Main measures included insulin sensitivity, sleep efficiency, and fragmentation. RESULTS: Insulin sensitivity was lower in craniopharyngioma subjects compared with control subjects (0.96 +/- 0.34 vs. 1.67 +/- 0.7, P = 0.01). Sleep-onset latency (19.3 +/- 27.8 vs. 31.9 +/- 23.4, P = 0.03) and oxygen saturations (rapid eye movement sleep: 89.0 +/- 5.1 vs. 94.2 +/- 2.3, P < 0.001; non-rapid eye movement sleep: 88.4 +/- 5.6 vs. 94.3 +/- 1.5, P < 0.001) were lower in craniopharyngioma. Obstructive apnea-hypopnea index (OAHI) (7.5 +/- 9.0 vs. 1.5 +/- 1.5, P = 0.03) was higher in craniopharyngioma. Respiratory distress index and OAHI correlated negatively with adiponectin concentrations (r = -0.61, P = 0.03, r = -0.71, P = 0.006, respectively) in craniopharyngioma. On multiple regression, TNF-alpha and craniopharyngioma were independent positive predictors of sleep-onset latency and adiponectin and craniopharyngioma were significant predictors (negative and positive, respectively) of OAHI. CONCLUSIONS: SDB is increased in adolescents with craniopharyngioma-related obesity compared with BMI-matched controls. Routine polysomnography should be considered in obese patients with craniopharyngioma and appropriate treatment initiated.
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Hypothalamic injury may predispose to apnea even independent of injury-related obesity.
“thus, it is possible that hypothalamic injury predisposes to apnea even independent of injury-related obesity.”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [70]
Some studies suggest that individuals with craniopharyngiomas have higher rates of sleep apnea compared to weight-matched controls.
“Some, though not all, studies suggest that individuals with craniopharyngiomas have higher rates of sleep apnea when compared to weight-matched controls (70, 71);”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [70]
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Features of the metabolic syndrome after childhood craniopharyngioma
Srinivasan, S., Ogle, G. D., Garnett, S. P., Briody, J. N., Lee, J. W., & Cowell, C. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030442 · Cited by 211 · see citing works
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- Rosen GM, Bendel AE, Neglia JP, Moertel CL, Mahowald M 2003 Sleep in children with neoplasms of the central nervous system: case review of 14 children. Pediatrics 112:e46 -54
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Approach to the patient with acquired hypothalamic syndrome
Grishman, E. K., & McCormack, S. E. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag197
- Authors
- O'Gorman, C. S., Simoneau-Roy, J., Pencharz, P., MacFarlane, J., MacLusky, I., Narang, I., Adeli, K., Daneman, D., & Hamilton, J.
- Affiliations
- Divisions of Endocrinology (C.S.O., J.S.-R., D.D., J.H.), Toronto, Ontario, Canada M5G 1X8
- University of Toronto (CA)
- Children's Hospital of Eastern Ontario (CA)
- Corresponding author
- Hamilton, Jill
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2010-05-01
- Volume
- 95
- Issue
- 5
- Pages
- 2211-2218
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2021568308
- Cited by
- 72
- References
- 1
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- University of Limerick Institutional Repository (University of Limerick) (acceptedVersion, cc-by-nc-sa)
- University of Limerick Institutional Repository (University of Limerick) (submittedVersion, cc-by-nc-sa)
- University of Limerick Institutional Repository (University of Limerick)
- Funders
- Université de Sherbrooke
- University of Limerick
- Novo Nordisk
- Hospital for Sick Children
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- sleep-disordered breathing, hypothalamic obesity, adolescent obesity, insulin resistance, adiponectin, TNF-α, leptin, adipokines, obstructive sleep apnea, sleep efficiency, sleep fragmentation, oxygen saturation, visceral adipose tissue, body mass index, glucose tolerance, sleep latency, apnea-hypopnea index
- MeSH terms
- Adolescent, Child, Craniopharyngioma, Female, Humans, Male, Obesity, Pituitary Neoplasms, Respiration Disorders, Sleep Wake Disorders, Body Mass Index, Body Size, Adiponectin, Young Adult
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