Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis
Abstract
CONTEXT AND OBJECTIVE: The dysregulation of hepatokines may be associated with the pathogenesis of insulin resistance and type 2 diabetes. A recent study has suggested that selenoprotein P (SeP), a novel hepatokine, may play a role in the regulation of glucose metabolism and insulin sensitivity. We examined the relationship between circulating SeP levels and clinical parameters associated with insulin resistance in humans. PARTICIPANTS AND METHODS: We compared serum SeP concentrations in 100 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the relationship between SeP and cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein, and carotid intima-media thickness. RESULTS: Serum SeP concentrations were significantly higher in patients with type 2 diabetes or prediabetes than those with normal glucose tolerance (all P < 0.01) and decreased in a stepwise manner [1032.4 (495.9-2149.4) vs. 867.3 (516.3-1582.7) vs. 362.0 (252.5-694.5), P = 0.004]. In addition, overweight and obese subjects had significantly increased SeP levels compared with lean subjects (P = 0.002). Spearman's partial correlation analysis adjusted for age and gender showed a significant relationship between SeP and cardiometabolic factors including body mass index, waist circumference, systolic blood pressure, triglycerides, glucose, hemoglobin A1c, aspartate aminotransferase, and insulin resistance. Furthermore, in multiple regression analyses, SeP showed an independent association with carotid intima-media thickness as well as high-sensitivity C-reactive protein, even after adjustment for other confounding factors. CONCLUSIONS: Circulating SeP concentrations were elevated in patients with glucose metabolism dysregulation and were related to various cardiometabolic parameters including insulin resistance, inflammation, and atherosclerosis.
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SeP is associated with insulin resistance and increased serum triglyceride, and patients with NAFLD, obesity, and type 2 diabetes have high circulating levels of SeP.
“SeP is associated with insulin resistance and increased serum triglyceride, and patients with NAFLD, obesity, and type 2 diabetes have high circulating levels of SeP [260,263,264] (Table 1).”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [264]
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References 19 · Cited by 191
- Authors
- Yang, S. J., Hwang, S. Y., Choi, H. Y., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M.
- Affiliations
- Korea University (KR)
- Corresponding author
- Choi, K. M.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2011-08
- Volume
- 96
- Issue
- 8
- Pages
- E1325-E1329
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2171548660
- Cited by
- 191
- References
- 19
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 18 · 2021: 10 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 10 · 2013: 17 · 2012: 11
- FWCI
- 9.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea University Guro Hospital
- National Research Foundation
- Korea University
- Ministry of Education and Human Resources Development (A102065-1011-1070100)
- Directorate for Education and Human Resources
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- selenoprotein P, type 2 diabetes, prediabetes, insulin resistance, hepatokines, inflammation, atherosclerosis, carotid intima-media thickness, high-sensitivity C-reactive protein, cardiometabolic risk factors, obesity, glucose tolerance
- MeSH terms
- Adult, Blood Glucose, C-Reactive Protein, Carotid Artery Diseases, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Insulin Resistance, Male, Middle Aged, Prediabetic State, Ultrasonography, Tunica Intima, Tunica Media, Selenoprotein P
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