The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Hyperparathyroidism in Patients with Primary Aldosteronism: Cross-Sectional and Interventional Data from the GECOH Study
Open accessAbstract
Context: Experimental studies suggest that aldosterone induces hypercalciuria and might contribute to hyperparathyroidism. Objective: We aimed to test for differences in PTH levels and parameters of calcium and vitamin D metabolism in patients with primary aldosteronism (PA) compared with patients with essential hypertension (EH) and to evaluate the impact of PA treatment on these laboratory values. Design, Setting, and Participants: The Graz Endocrine Causes of Hypertension study includes hypertensive patients referred for screening for endocrine hypertension at a tertiary care center in Graz, Austria. Main Outcome Measures: Differences in PTH levels between patients with PA and EH. Results: Among 192 patients, we identified 10 patients with PA and 182 with EH. PTH levels (mean ± sd in picograms per milliliter) were significantly higher in PA patients compared with EH (67.8 ± 26.9 vs. 46.5 ± 20.9; P = 0.002). After treatment of PA with either adrenal surgery (n = 5) or mineralocorticoid receptor antagonists (n = 5), PTH concentrations decreased to 43.9 ± 14.9 (P = 0.023). Serum 25-hydroxyvitamin D concentrations were similar in both groups. Compared with EH, serum calcium concentrations were significantly lower (2.35 ± 0.10 vs. 2.26 ± 0.10 mmol/liter; P = 0.013), and there was a nonsignificant trend toward an increased spot urine calcium to creatinine ratio in PA [median (interquartile range) 0.19 (0.11–0.31) vs. 0.33 (0.12–0.53); P = 0.094]. Conclusions: Our results suggest that PA contributes to secondary hyperparathyroidism. Further studies are warranted to evaluate whether PTH has implications for PA diagnostics and whether mineralocorticoid receptor antagonists have a general impact on PTH and calcium metabolism.
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“Although we did not have urine calcium measurements in this study, prior research has shown that chronic aldosterone excess results in hypercalciuria and hypocalcemia16,38,39.”
From Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone (2014) · cites this paper as [16]
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Adrenal Function and Skeletal Regulation
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Case Report: Hyperparathyroidism in a Patient with Aldosterone-producing Adenoma
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A Correlative Study of Bone Metabolism Markers and Primary Aldosteronism
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Metadata
- Authors
- Pilz, S., Kienreich, K., Drechsler, C., Ritz, E., Fahrleitner-Pammer, A., Gaksch, M., Meinitzer, A., März, W., Pieber, T. R., & Tomaschitz, A.
- Affiliations
- Amsterdam Public Health (NL)
- Department of Internal Medicine (S.P., K.K., A.F.-P., M.G., T.R.P., A.T.), 8036 Graz, Austria
- University of Würzburg (DE)
- University Hospital Heidelberg (DE)
- Medical University of Graz (AT)
- Corresponding author
- Pilz, Stefan
- Tomaschitz, Andreas
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2012-01-01
- Volume
- 97
- Issue
- 1
- Pages
- E75-E79
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2074546237
- Cited by
- 118
- References
- 21
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 11
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Austrian Federal Ministry of Economy, Family and Youth
- Oesterreichische Nationalbank (13905, 825329)
- Bundesministerium für Verkehr, Innovation und Technologie
- Steirische Wirtschaftsförderungsgesellschaft
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
- Keywords
- primary aldosteronism, secondary hyperparathyroidism, parathyroid hormone, essential hypertension, mineralocorticoid receptor antagonists, adrenal surgery, hypercalciuria, vitamin D metabolism, serum calcium, endocrine hypertension
- MeSH terms
- Adult, Aged, Aldosterone, Blood Pressure, Clinical Trials as Topic, Cross-Sectional Studies, Data Interpretation, Statistical, Female, Follow-Up Studies, Humans, Hyperaldosteronism, Hyperparathyroidism, Hypertension, Male, Middle Aged, Parathyroid Hormone, Renin-Angiotensin System
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