Evaluation of Adverse Outcome in Young Women with Polycystic Ovary Syndrome Versus Matched, Reference Controls: A Retrospective, Observational Study
Abstract
Context Polycystic ovary syndrome (PCOS) is associated with insulin resistance, hyperandrogenism, and dyslipidemia, but the effects of these disturbances on long-term health are not fully understood. Aim Our aim was to determine the relative risk of type 2 diabetes, cancer, large-vessel disease (LVD), and all-cause mortality for women diagnosed with PCOS. Design Data were extracted from the General Practice Research Database, a longitudinal, anonymized research database derived from nearly 600 primary-care practices in the United Kingdom. Patients with a diagnosis of PCOS between 1990 and 2010 were selected. Patients were matched to two sets of controls. The first set was matched according to primary-care practice and age, and the second was also matched on body mass index. Primary outcome was first incident record of diabetes. Crude rates for diabetes were presented, and time to diabetes was analyzed using Cox proportional hazard models. Secondary outcomes (cancer, LVD, and mortality) were also modeled. Results Of 53,303 identified with a diagnosis of PCOS, 21,740 (40.8%) met the eligibility criteria. Median follow-up was 4.7 yr (interquartile range = 2.0-8.6 yr) in those with PCOS and 5.8 yr (2.7-9.6) in the reference group. Crude rates of diabetes were 5.7 and 1.7 per 1000 patient-years for cases and controls, respectively. The corresponding adjusted hazard ratio was 3.015 (95% confidence interval = 2.733-3.327). Of cases matched by body mass index, crude rates of diabetes…
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Few population studies have been conducted on the range of morbidities experienced in women with PCOS compared to age-matched controls across the lifespan.
“Few population studies have been conducted on the range of morbidities that are experienced in women with PCOS, as compared to age-matched controls across the lifespan—adolescence, reproductive age, the menopausal period, and the elderly years.2,31, 32, 33”
From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [33]
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- Authors
- Morgan, C. L., Jenkins-Jones, S., Currie, C. J., & Rees, D. A.
- Affiliations
- Cardiff University (GB)
- Pharmatelligence (S.J.J.), Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, United Kingdom
- Molecular and Experimental Medicine (D.A.R.), School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2012-09-01
- Volume
- 97
- Issue
- 9
- Pages
- 3251-3260
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1986309137
- Cited by
- 136
- References
- 45
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 14 · 2020: 9 · 2019: 14 · 2018: 18 · 2017: 11 · 2016: 11 · 2015: 12 · 2014: 16 · 2013: 2 · 2012: 2
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, type 2 diabetes, cancer risk, large vessel disease, all-cause mortality, insulin resistance, hyperandrogenism, dyslipidemia, young women, body mass index, long-term health effects
- MeSH terms
- Adult, Cardiovascular Diseases, Cerebrovascular Disorders, Cholesterol, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Longitudinal Studies, Neoplasms, Polycystic Ovary Syndrome, Primary Health Care, Retrospective Studies, Smoking, Body Mass Index, Proportional Hazards Models, Peripheral Vascular Diseases, Treatment Outcome, Disease Progression, Endpoint Determination, Young Adult
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