Acromegaly Has a Negative Influence on Trabecular Bone, But Not on Cortical Bone, as Assessed by High-Resolution Peripheral Quantitative Computed Tomography
Abstract
Introduction Acromegaly is one of the causes of secondary osteoporosis, although studies of bone mineral density (BMD) have yielded conflicting results and none of them have evaluated the bone properties. Objectives and patients Our objective was to correlate, in a cohort of 82 acromegalic patients, BMD and bone microarchitecture, using dual-energy x-ray absorptiometry and high-resolution peripheral quantitative computed tomography, with the presence of type 2 diabetes mellitus (T2DM), disease activity, and gonadal status and to compare these bone parameters between 45 eugonadal acromegalic patients and 45 healthy controls. Results Acromegalic patients with T2DM had lower trabecular density and trabecular bone volume to tissue volume ratio in the distal tibia. Patients with active acromegaly exhibited a higher BMD and T-score in the lumbar spine (P = .02 for both) and a higher cortical density in the distal tibia when compared with those with controlled acromegaly (P = .001). After multiple linear regression (including age, presence of T2DM, acromegaly activity, and gonadal status), eugonadism remained the main determinant of bone parameters. The 45 acromegalic patients with eugonadism were compared with 45 age- and sex-matched controls and exhibited lower trabecular densities and impaired microstructures. Conclusions Acromegaly appears to have a deleterious effect on trabecular bone microarchitecture, and in this specific population, the gonadal status might be more importan…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Information about the influence of GH excess on BMD varies in the literature: in some studies BMD was increased or within reference ranges, while in other papers it was decreased.
“Information about the influence of GH excess on BMD varies in the literature. In some studies BMD was reported to be increased or within the reference ranges, while in other papers it was decreased [17, 26, 34–37].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [26]
Acromegaly is characterized by excessive growth hormone secretion and in most cases is caused by a somatotroph tumor of the pituitary gland.
“Acromegaly is characterized by growth hormone (GH) excessive secretion and in most cases is caused by the presence of a somatotroph tumor of the pituitary gland [25, 26].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [26]
Bone quality depends not only on bone density and bone turnover but also on collagen integrity and the macrostructure and microstructure of bone.
“Bone quality depends not only on bone density and bone turnover but also on collagen integrity and the macrostructure and microstructure of bone [26].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [26]
Patients with acromegaly have an increased risk of fractures, which might be correlated with insufficient quality of bone.
“Patients with acromegaly have an increased risk of fractures, which might be correlated with insufficient quality of bone [26, 27, 39, 42].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [26]
DXA and QUS methods are not sufficient for identifying patients at risk for fracture, due to possible interferences including bone deformities, osteoarthritis, joint rigidity, and soft tissue thickening.
“However, DXA and QUS methods are not sufficient for identifying patients at risk for fracture, due to the many possible interferences including bone deformities, osteoarthritis, joint rigidity, and soft tissue thickening [26, 27].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [26]
The citation lists haven’t been fetched yet
References 37 · Cited by 114
- Authors
- Madeira, M., Neto, L. V., de Paula Paranhos Neto, F., Barbosa Lima, I. C., Carvalho de Mendonça, L. M., Gadelha, M. R., & Fleiuss de Farias, M. L.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Division of Endocrinology, Department of Internal Medicine, Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro (M.M., L.V.N., F.d.P.P.N., L.M.C.d.M., M.R.G., M.L.F.d.F.)
- Nuclear Instrumentation Laboratory, COPPE/Universidade Federal do Rio de Janeiro (I.C.B.L.), Rio de Janeiro 21941-913, Brazil
- Corresponding author
- Madeira, Miguel
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-04-01
- Volume
- 98
- Issue
- 4
- Pages
- 1734-1741
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1981238527
- Cited by
- 114
- References
- 37
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 9 · 2020: 9 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 7 · 2013: 1
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidade Federal do Rio de Janeiro
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- acromegaly, trabecular bone, cortical bone, bone microarchitecture, type 2 diabetes, gonadal status, bone mineral density, secondary osteoporosis, disease activity, distal tibia, lumbar spine, high-resolution peripheral quantitative computed tomography
- MeSH terms
- Acromegaly, Adult, Aged, Aged, 80 and over, Bone and Bones, Diabetes Mellitus, Type 2, Female, Humans, Lumbar Vertebrae, Male, Middle Aged, Tibia, Tomography, X-Ray Computed, Cohort Studies, Bone Density, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
