The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes
Open accessAbstract
Context: There is no doubt that vitamin D must be activated to the hormonal form 1,25-dihydroxyvitamin D to achieve full biological activity or that many tissues participate in this activation process—be it endocrine or autocrine. We believe that not only is 25-hydroxyvitamin D important to tissue delivery for this activation process, but also that intact vitamin D has a pivotal role in this process. Objective: In this review, evidence on the vitamin D endocrine/autocrine system is presented and discussed in relation to vitamin D-binding protein affinity, circulating half-lives, and enzymatic transformations of vitamin D metabolites, and how these affect biological action in any given tissue. Conclusions: Circulating vitamin D, the parent compound, likely plays an important physiological role with respect to the vitamin D endocrine/autocrine system, as a substrate in many tissues, not originally thought to be important. Based on emerging data from the laboratory, clinical trials, and data on circulating 25-hydroxyvitamin D amassed during many decades, it is likely that for the optimal functioning of these systems, significant vitamin D should be available on a daily basis to ensure stable circulating concentrations, implying that variation in vitamin D dosing schedules could have profound effects on the outcomes of clinical trials because of the short circulating half-life of intact vitamin D.
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1 retracted
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Cited by
Roth, D. E., Abrams, S. A., Aloia, J., Bergeron, G., Bourassa, M. W., Brown, K. H., Calvo, M. S., Cashman, K. D., Combs, G., De‐Regil, L. M., et al. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13968 · Cited by 527
Scragg, R., Stewart, A. W., Waayer, D., Lawes, C. M. M., Toop, L., Sluyter, J., Murphy, J., Khaw, K.-T., & Camargo, C. A. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.0175 · Cited by 482
Vitamin D in Chronic Kidney Disease and Dialysis Patients
Jean, G., Souberbielle, J., & Chazot, C. (2017) · Nutrients · doi:10.3390/nu9040328 · Cited by 355
Standardizing vitamin D assays: The way forward
Binkley, N., Sempos, C. T., & (VDSP), F. T. V. D. S. P. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2252 · Cited by 204
Dawson-Hughes, B., Staten, M. A., Knowler, W. C., Nelson, J., Vickery, E. M., LeBlanc, E. S., Neff, L. M., Park, J., & Pittas, A. G. (2020) · Diabetes Care · doi:10.2337/dc20-1765 · Cited by 192
Metadata
- Authors
- Hollis, B. W., & Wagner, C. L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-12-01
- Volume
- 98
- Issue
- 12
- Pages
- 4619-4628
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2145798427
- Cited by
- 293
- References
- 101
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Hollis, B. W., & Wagner, C. L. (2013). The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2013-2653
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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