Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of Cognitive Impairment in Elderly: Korean Longitudinal Study on Health and Aging (KLoSHA)
Abstract
Context The association between subclinical hyperthyroidism and the risk of dementia has been validated in several studies. However, the effect of thyroid function within reference range on the risk of cognitive dysfunction including mild cognitive impairment (MCI) and dementia is still unclear. Objective Our aim was to investigate the association between thyroid function and the risk of MCI and dementia in euthyroid elderly subjects. Design, setting, and participants We conducted a population-based prospective study as a part of the Korean Longitudinal Study on Health and Aging. A total of 313 participants who were euthyroid and nondemented at baseline and completed cognitive function tests at a 5-year follow-up evaluation (mean age 72.5 ± 6.9 y) were analyzed in the present study. Main outcome measure Baseline thyroid function was compared according to the development of MCI or dementia during the study period. Binary logistic regression analysis was performed to investigate the independent association between thyroid function and cognitive impairment. Results At baseline evaluation, 237 subjects were cognitively normal, and 76 subjects had MCI. Diagnoses of cognitive function in 259 subjects remained unchanged or improved during the study period (nonprogression group), whereas 54 subjects showed progression of cognitive impairment to MCI or dementia (progression group). In the progression group, baseline serum TSH levels were lower than those in nonprogression group. Basel…
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A subsequent population-based prospective study from Korea showed that low serum TSH levels are independently associated with the risk of cognitive impairment and dementia in the elderly.
“Similarly, a subsequent population-based prospective study from Korea showed that low serum TSH levels are independently associated with the risk of cognitive impairment and dementia in the elderly [60] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [60]
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References 42 · Cited by 68
- Authors
- Moon, J. H., Park, Y. J., Kim, T. H., Han, J. W., Choi, S. H., Lim, S., Park, D. J., Kim, K. W., & Jang, H. C.
- Affiliations
- Department of Internal Medicine (J.H.M., S.H.C., S.L., H.C.J.), Seongnam 463-707, Korea
- Seoul National University (KR)
- Corresponding author
- Kim, Ki Woong
- Jang, Hak Chul
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2014-02-01
- Volume
- 99
- Issue
- 2
- Pages
- 424-432
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1974962748
- Cited by
- 68
- References
- 42
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 9 · 2015: 6 · 2014: 4
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- serum TSH, mild cognitive impairment, dementia, cognitive impairment progression, thyroid function, free thyroxine
- MeSH terms
- Aged, Aged, 80 and over, Aging, Cognition, Cognition Disorders, Dementia, Female, Health Surveys, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Risk Factors, Thyrotropin, Disease Progression, Asian People, Republic of Korea
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