Irisin in response to exercise in humans with and without metabolic syndrome
Abstract
CONTEXT: Irisin is a recently identified exercise-induced myokine. However, the circulating levels of irisin in response to different types of exercise in subjects with metabolic syndrome are unknown. OBJECTIVE: This study aimed to study the levels of irisin in healthy males and subjects with metabolic syndrome at baseline and in response to exercise. DESIGN: Each individual completed high-intensity interval exercise (HIIE), continuous moderate-intensity exercise (CME), and resistance exercise (RE) sessions in a random, crossover design. Percentage change in circulating irisin levels was examined. Two different irisin assays were used to compare the results of the RE study. RESULTS: Circulating irisin increased immediately after HIIE, CME, and RE and declined 1 hour later. The increase was greater in response to resistance compared with either high-intensity intermittent exercise or CME. Change in irisin in response to exercise did not differ between individuals with and without metabolic syndrome. CONCLUSIONS: Exercise is able to increase circulating irisin levels in individuals with the metabolic syndrome as well as healthy individuals. Whether this increase may contribute to the beneficial effects of exercise on patients with the metabolic syndrome remains to be studied further.
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Some studies report decreased circulating irisin in obese populations following training, potentially related to improvement of irisin resistance, a compensatory elevation in obesity due to reduced target tissue sensitivity.
“some studies report decreased circulating irisin in obese populations following training, potentially related to improvement of irisin resistance—a compensatory elevation in obesity due to reduced target tissue sensitivity [19,42,43].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [19]
Training status can affect both baseline and exercise-induced myokine levels; individuals with metabolic syndrome exhibit attenuated irisin responses, and failure to distinguish acute and chronic measurement time points may have contributed to contradictory findings.
“Training status can affect both baseline and exercise-induced myokine levels. For instance, individuals with metabolic syndrome have been found to exhibit attenuated irisin responses [19], and failure to distinguish between acute and chronic measurement time points may have contributed to some contradictory findings in the literature [18,42,50,80].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [19]
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References 23 · Cited by 210
- Authors
- Huh, J. Y., Siopi, A., Mougios, V., Park, K. H., & Mantzoros, C. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Aristotle University of Thessaloniki (GR)
- Corresponding author
- Mantzoros, Christos S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-03
- Volume
- 100
- Issue
- 3
- Pages
- E453-E457
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1984956709
- Cited by
- 210
- References
- 23
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 23 · 2023: 14 · 2022: 28 · 2021: 24 · 2020: 24 · 2019: 16 · 2018: 20 · 2017: 19 · 2016: 11 · 2015: 14
- FWCI
- 14.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- irisin, metabolic syndrome, physical activity, myokines, high-intensity interval exercise, moderate-intensity continuous training, resistance training, exercise response
- MeSH terms
- Adult, Fibronectins, Humans, Male, Middle Aged, Physical Endurance, Running, Exercise, Walking, Cross-Over Studies, Metabolic Syndrome, Resistance Training
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