One-Hour Postload Hyperglycemia Is a Stronger Predictor of Type 2 Diabetes Than Impaired Fasting Glucose
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Context: Subjects with normal glucose tolerance (NGT) but 1-h postload glucose ≥ 155 mg/dL (NGT-1h-high) exhibit an intermediate cardiometabolic risk profile between individuals with NGT and impaired glucose tolerance (IGT). Objective: This study aimed to evaluate whether NGT-1h-high subjects have different cardiometabolic characteristics and an increased risk of type 2 diabetes compared with individuals with isolated impaired fasting glucose (IFG). Setting, Design, and Patients: A cross-sectional analysis was performed on 595 nondiabetic subjects who underwent an oral glucose tolerance test and an euglycemic hyperinsulinemic clamp in an ambulatory care setting. In addition, a longitudinal analysis was performed on 392 individuals, who were reexamined after a followup of 5.2 ± 0.9 y. Main Outcome Measures: Insulin sensitivity, beta-cell function, and risk of developing diabetes were measured. Results: Subjects with NGT-1h-high have a significant reduction of peripheral insulin sensitivity and beta-cell function, assessed by the disposition index, compared with either 1-h postload glucose < 155 mg/dL (NGT-1h-low) or IFG individuals, but not compared with IGT. Among the 392 subjects studied in the longitudinal analysis the incidence rate of type 2 diabetes over the follow-up period was 2.9, 16.7, 12.5, and 31.4% for subjects with NGT-1h-low, NGT-1h-high, IFG, and IGT, respectively. In a Cox proportional hazard regression analysis the risk of developing diabetes for NGT-1h-high subjects was 4.02 (95% confidence interval [CI] 1.06–15.26); an even higher risk (6.67; 95% CI, 2.09–21.24) was observed in subjects with IGT, but not in the isolated IFG group (1.91; 95% CI, 0.44–8.29). Conclusions: NGT-1h-high subjects exhibit a higher risk of developing diabetes than those with IFG or NGT-1h-low, likely due to decreased insulin sensitivity and beta-cell function.
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Patients with normal glucose tolerance and 1-hour blood glucose ≥155 mg/dl on OGTT have more diabetes risk than impaired fasting glucose.
“It has also been reported that patients with normal glucose tolerance and 1-hour blood glucose ≥155 mg/dl on OGTT cause more diabetes risk than impaired fasting glucose.[13]”
From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [13]
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References 35 · Cited by 138
Research works printed but not linked: 28
- Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose for prevention of type 2 diabetes mellitus: the STOP- NIDDM randomised trial. Lancet. 2002;359:2072-2077.
- Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose treatment and the risk of cardiovascular disease and hy- pertension in patients with impaired glucose tolerance: The STOP- NIDDM trial. JAMA 2003;290:486 -494.
- Ratner R, Goldberg R, Haffner S, et al. Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program. Diabetes Care. 2005;28:888 -894.
- Nathan DM, Davidson MB, DeFronzo RA, Heine RJ, Henry RR, Pratley R, Zinman B. Impaired fasting glucose and impaired glucose tolerance: Implications for care. Diabetes Care. 2007;30:753-759.
- International Expert Committee. International expert committee re- port on the role of the A1C assay in the diagnosis of diabetes. Di- abetes Care. 2009;32:1327-1334.
- Laakso M, Zilinskaite J, Hansen T, et al. Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. Diabetologia. 2008;51:502-511.
- Abdul-Ghani MA, Abdul-Ghani T, Ali N, Defronzo RA. One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes. Diabetes Care. 2008; 31:1650 -1655.
- Abdul-Ghani MA, Lyssenko V, Tuomi T, DeFronzo RA, Groop L. Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study. Diabetes Care. 2009;32:281-286.
- Priya M, Anjana RM, Chiwanga FS, Gokulakrishnan K, Deepa M, Mohan V. 1-hour venous plasma glucose and incident prediabetes and diabetes in Asian Indians. Diabetes Technol Ther. 2013;15: 497-502.
- Succurro E, Marini MA, Arturi F, et al. Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose toler- ance but early carotid atherosclerosis. Atherosclerosis. 2009;207: 245-249.
- Succurro E, Arturi F, Lugarà M, et al. One-hour postload plasma glucose levels are associated with kidney dysfunction. Clin J Am Soc Nephrol. 2010;5:1922-1927.
- Sciacqua A, Miceli S, Carullo G, et al. One-hour postload plasma glucose levels and left ventricular mass in hypertensive patients. Diabetes Care. 2011;34:1406 -1411.
- Sciacqua A, Miceli S, Greco L, et al. One-hour postload plasma glucose levels and diastolic function in hypertensive patients. Dia- betes Care. 2011;34:2291-2296.
- Marini MA, Succurro E, Frontoni S, et al. Insulin sensitivity, -cell function, and incretin effect in individuals with elevated 1-hour post- load plasma glucose levels. Diabetes Care. 2012;35:868 -872.
- Perticone F, Sciacqua A, Perticone M, et al. Serum uric acid and 1-h postload glucose in essential hypertension. Diabetes Care. 2012;35: 153-157.
- Sciacqua A, Maio R, Miceli S, et al. Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension. PLoS One. 2012;7:e44470.
- Marini MA, Frontoni S, Succurro E, et al. Decreased insulin clear- ance in individuals with elevated 1-h post-load plasma glucose lev- els. PLoS One. 2013;8:e77440.
- Sciacqua A, Perticone M, Grillo N, et al. Vitamin D and 1-hour post-load plasma glucose in hypertensive patients. Cardiovasc Dia- betol. 2014;13:48.
- Sesti G, Fiorentino TV, Succurro E, et al. Elevated 1-h post-load plasma glucose levels in subjects with normal glucose tolerance are associated with unfavorable inflammatory profile. Acta Diabetol. 2014;51:927-932.
- Sesti G, Hribal ML, Fiorentino TV, Sciacqua A, Perticone F. Ele- vated 1 h postload plasma glucose levels identify adults with normal glucose tolerance but increased risk of non-alcoholic fatty liver dis- ease. BMJ Open Diab Res Care. 2014;2:e000016.
- Bianchi C, Miccoli R, Trombetta M, et al. Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose toler- ance but impaired -cell function, insulin resistance, and worse car- diovascular risk profile: the GENFIEV study. J Clin Endocrinol Metab. 2013;98:2100 -2105.
- Marini MA, Frontoni S, Mineo D, et al. The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. J Clin Endocrinol Metab. 2003;88:3368 -3371.
- WHO Expert Committee on Diabetes Mellitus: Second report. World Health Organ Tech Rep Ser. 1980;646:1-80.
- Abdul-Ghani MA, Williams K, DeFronzo RA, Stern M. What is the best predictor of future type 2 diabetes? Diabetes Care. 2007;30: 1544 -1548.
- Manco M, Panunzi S, Macfarlane DP, et al. One-hour plasma glu- cose identifies insulin resistance and beta-cell dysfunction in indi- viduals with normal glucose tolerance: Cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study. Diabetes Care. 2010;33:2090 -2097.
- Alyass A, Almgren P, Akerlund M, et al. Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: Results from two prospective cohorts. Diabetologia. 2015;58:87-97.
- Schellenberg ES, Dryden DM, Vandermeer B, Ha C, Korownyk C. Lifestyle interventions for patients with and at risk for type 2 dia- betes: A systematic review and meta-analysis. Ann Intern Med. 2013;159:543-551.
- Saito T, Watanabe M, Nishida J, et al. Lifestyle modification and prevention of type 2 diabetes in overweight Japanese with impaired fasting glucose levels: A randomized controlled trial. Arch Intern Med. 201;171:1352-1360. doi: 10.1210/jc.2015-2573 press.endocrine.org/journal/jcem · DOI
- Authors
- Fiorentino, T. V., Marini, M. A., Andreozzi, F., Arturi, F., Succurro, E., Perticone, M., Sciacqua, A., Hribal, M. L., Perticone, F., & Sesti, G.
- Affiliations
- Magna Graecia University (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Sesti, Giorgio
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-10-01
- Volume
- 100
- Issue
- 10
- Pages
- 3744-3751
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1845326899
- Cited by
- 138
- References
- 35
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 17 · 2019: 13 · 2018: 15 · 2017: 13 · 2016: 16 · 2015: 2
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes risk, impaired fasting glucose, impaired glucose tolerance, insulin sensitivity, beta-cell function, disposition index, cardiometabolic risk, prediabetes, oral glucose tolerance test, hyperinsulinemic-euglycemic clamp
- MeSH terms
- Adult, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Fasting, Female, Glucose Tolerance Test, Humans, Hyperglycemia, Insulin Resistance, Male, Middle Aged, Glucose Clamp Technique
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