The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study
Open accessAbstract
Context: Growth hormone (GH) is prescribed for an increasing range of indications, but there has been concern that it might raise cancer risk. Published data are limited. Objective: To examine cancer risks in relation to GH treatment. Design: Cohort study. Setting: Population-based. Patients: Cohort of 23,984 patients treated with recombinant human GH (r-hGH) in eight European countries since this treatment was first used in 1984. Cancer expectations from country-specific national population statistics. Main Outcome Measures: Cancer incidence and cancer mortality. Results: Incidence and mortality risks in the cohort were raised for several cancer sites, largely consequent on second primary malignancies in patients given r-hGH after cancer treatment. There was no clear raised risk in patients with growth failure without other major disease. Only for bone and bladder cancers was incidence significantly raised in GH-treated patients without previous cancer. Cancer risk was unrelated to duration or cumulative dose of r-hGH treatment, but for patients treated after previous cancer, cancer mortality risk increased significantly with increasing daily r-hGH dose (P trend < 0.001). Hodgkin lymphoma (HL) incidence increased significantly with longer follow-up (P trend = 0.001 for patients overall and 0.002 for patients without previous cancer). Conclusions: Our results do not generally support a carcinogenic effect of r-hGH, but the unexplained trend in cancer mortality risk in relation to GH dose in patients with previous cancer, and the indication of possible effects on bone cancer, bladder cancer, and HL risks, need further investigation.
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“data from GH registries provide no evidence of an increase in risk of neoplasia with treatment.173,208,222-224”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [223]
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Cites
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Growth Promotion Ethics and the Challenge to Resist Cosmetic Endocrinology
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Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
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“For the three cancer sites for which there is most published support for an association with IGF-1 levels— colorectum, breast, and prostate (2)—the evidence from our cohort and previously (9, 10, 18, 19) is too sparse to reach a conclusion on relations to GH treatment, reflecting the rarity of these cancers at childho…”
BackgroundSklar, C. A., Mertens, A. C., Mitby, P. A., Occhiogrosso, G., Qin, J., Heller, G., Yasui, Y., & Robison, L. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8606 · Cited by 307
Long-term safety of recombinant human growth hormone in children
Bell, J., Parker, K. L., Swinford, R. D., Hoffman, A. R., Maneatis, T., & Lippe, B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0178 · Cited by 301 · cited 2×
“, neurofibromatosis) that lead to GH therapy are themselves strong predisposing factors for cancer, we followed previous practice (11, 12, 16) in excluding individuals with such conditions (listed in Supplemental Data) from analysis.”
BackgroundMethodCarel, J., Écosse, E., Landier, F., Meguellati-Hakkas, D., Kaguelidou, F., Rey, G., & Coste, J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1995 · Cited by 295
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Growth Hormone Treatment and Risk of Second Neoplasms in the Childhood Cancer Survivor
Ergun-Longmire, B., Mertens, A. C., Mitby, P. A., Qin, J., Heller, G., Shi, W., Yasui, Y., Robison, L. L., & Sklar, C. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0656 · Cited by 272 · cited 4×
“Potential effects on leukemia (5, 6) and other malignancy (1) risks have been suggested, and second primary malignancy risk has been shown raised in patients receiving GH after childhood cancer (7, 8).”
BackgroundInfluentialSvensson, J., Bengtsson, B. ‐., Rosén, T., Odén, A., & Johannsson, G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031601 · Cited by 236
Research works printed but not linked: 1
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Growth hormone — past, present and future
Ranke, M. B., & Wit, J. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.22 · Cited by 362
Turner syndrome: mechanisms and management
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“Furthermore, children treated with GH have been found to have an increased incidence of osteosarcoma [30].”
BackgroundClinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224
Hokken-Koelega, A., van der Steen, M., Boguszewski, M. C. D. S., Cianfarani, S., Dahlgren, J., Horikawa, R., Verónica Mericq, G., Rapaport, R., Al-Herbish, A. S., Braslavsky, D. G., et al. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad002 · Cited by 208
Metadata
- Authors
- Swerdlow, A. J., Cooke, R., Beckers, D., Borgström, B., Butler, G., Carel, J.-C., Cianfarani, S., Clayton, P., Coste, J., Deodati, A., Ecosse, E., Gausche, R., Giacomozzi, C., Hokken-Koelega, A. C. S., Khan, A. J., Kiess, W., Kuehni, C. E., Mullis, P.-E., Pfaffle, R., Sävendahl, L., Sommer, G., Thomas, M., Tidblad, A., Tollerfield, S., Van Eycken, L., & Zandwijken, G. R. J.
- Affiliations
- Institute of Cancer Research (GB)
- UCLouvain (BE)
- Karolinska Institutet (SE)
- National Health Service (GB)
- Inserm (FR)
- University of Rome Tor Vergata (IT)
- Leipzig University (DE)
- Azienda Ospedaliera Carlo Poma (IT)
- Erasmus MC (NL)
- University of Bern (CH)
- University Hospital of Bern (CH)
- University College London (GB)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2017-02-10
- Volume
- 102
- Issue
- 5
- Pages
- 1661-1672
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC6061931
- OpenAlex
- W2597357044
- Cited by
- 153
- References
- 31
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 16 · 2023: 14 · 2022: 23 · 2021: 16 · 2020: 19 · 2019: 26 · 2018: 18 · 2017: 6
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- Digital Access to Libraries (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Funders
- Eli Lilly and Company
- Pfizer
- University College London
- European Commission (223497)
- Cancerfonden
- Novo Nordisk
- Vetenskapsrådet
- Barncancerfonden
- Institut National Du Cancer
- Agence Française de Sécurité Sanitaire des Produits de Santé
- Ipsen
- Novo Nordisk Pharma
- FP7 Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
- Keywords
- recombinant human growth hormone, cancer risk, second primary malignancy, cancer mortality, cancer incidence, Hodgkin's disease, bone cancer, bladder cancer, growth hormone dose
- MeSH terms
- Adolescent, Urinary Bladder Neoplasms, Bone Diseases, Developmental, Bone Neoplasms, Child, Child, Preschool, Dose-Response Relationship, Drug, Europe, Female, Growth Disorders, Hodgkin Disease, Humans, Hypopituitarism, Infant, Infant, Newborn, Male, Neoplasms, Recombinant Proteins, Risk, Turner Syndrome, Cohort Studies, Incidence, Neoplasms, Second Primary, Human Growth Hormone, Renal Insufficiency, Chronic, Young Adult
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